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Literature DB >> 23649922

Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot.

Mantosh K Sinha¹, Kareem Khoury, Eberhardt Herdtweck, Alexander Dömling.

Abstract

Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation stereoselectively gave new tricyclic compounds. Examples are described in decent yields over two steps in one pot, and a crystal structure is also presented to support the proposed structures.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23649922 PMCID： PMC3740945 DOI： 10.1002/chem.201300962

Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236

18 in total

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Authors: L Weber
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Review 3. "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

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4. Efficient and diverse synthesis of indole derivatives.

Authors: Haixia Liu; Alexander Dömling
Journal: J Org Chem Date: 2009-09-04 Impact factor: 4.354

5. New application of Pictet-Spengler reaction leading to the synthesis of an unusual seven-membered heterocyclic ring system.

Authors: Bijoy Kundu; Devesh Sawant; Pankaj Partani; Amit P Kesarwani
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6. MCR synthesis of praziquantel derivatives.

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7. Synthetic studies on (-)-lemonomycin: stereocontrolled construction of the 3,8-diazabicyclo[3.2.1] skeleton.

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Journal: Chem Commun (Camb) Date: 2004-12-08 Impact factor: 6.222

8. Ugi 4-CR/Pictet-Spengler reaction as a short route to tryptophan-derived peptidomimetics.

Authors: Giordano Lesma; Roberto Cecchi; Sergio Crippa; Paola Giovanelli; Fiorella Meneghetti; Manuele Musolino; Alessandro Sacchetti; Alessandra Silvani
Journal: Org Biomol Chem Date: 2012-10-16 Impact factor: 3.876

9. Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

Authors: Kareem Khoury; Mantosh K Sinha; Tadamichi Nagashima; Eberhardt Herdtweck; Alexander Dömling
Journal: Angew Chem Int Ed Engl Date: 2012-09-11 Impact factor: 15.336

10. Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence.

Authors: Anass Znabet; Job Zonneveld; Elwin Janssen; Frans J J De Kanter; Madeleine Helliwell; Nicholas J Turner; Eelco Ruijter; Romano V A Orru
Journal: Chem Commun (Camb) Date: 2010-09-27 Impact factor: 6.222

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1. MCR synthesis of a tetracyclic tetrazole scaffold.

Authors: Pravin Patil; Kareem Khoury; Eberhardt Herdtweck; Alexander Dömling
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2. A universal isocyanide for diverse heterocycle syntheses.

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3. Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.

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Journal: Org Lett Date: 2019-04-29 Impact factor: 6.005

4. Crystal structure of tert-butyl 4-[4-(4-fluoro-phen-yl)-2-methyl-but-3-yn-2-yl]piperazine-1-carboxyl-ate.

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Journal: Acta Crystallogr E Crystallogr Commun Date: 2021-03-05

Review 5. The Pictet-Spengler Reaction Updates Its Habits.

Authors: Andrea Calcaterra; Laura Mangiardi; Giuliano Delle Monache; Deborah Quaglio; Silvia Balducci; Simone Berardozzi; Antonia Iazzetti; Roberta Franzini; Bruno Botta; Francesca Ghirga
Journal: Molecules Date: 2020-01-19 Impact factor: 4.411

5 in total