Literature DB >> 29340996

Recent advances in the development of polycyclic skeletons via Ugi reaction cascades.

Jie Lei1, Jiang-Ping Meng1, Dian-Yong Tang1, Brendan Frett2, Zhong-Zhu Chen3, Zhi-Gang Xu4.   

Abstract

Isocyanide-based multicomponent reactions are among the most powerful synthetic tools available. Particularly, the isocyanide-based Ugi reaction can allow rapid preparation of [Formula: see text]-aminoacyl amide derivatives and polyazaheterocycles with extensive pharmaceutical applications. Moreover, bridged polyazaheterocycles, including one or more quaternary carbon centers, can be constructed via the Ugi cascade reaction in a few steps. This review will emphasize synthesis and bioactivities of bridged compounds with quaternary centers constructed through Ugi cascade reactions.

Entities:  

Keywords:  Cyclization; Multicomponent reactions; Nitrogen-containing heterocycle; Polyazaheterocycle; Review; Ugi reaction

Mesh：

Substances：

Year:  2018        PMID： 29340996     DOI： 10.1007/s11030-017-9811-2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  66 in total

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Journal:  J Am Chem Soc       Date:  2010-11-10       Impact factor: 15.419

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Journal:  Org Lett       Date:  2014-02-19       Impact factor: 6.005

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