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Literature DB >> 20071213

Design strategies for the creation of artificial metalloenzymes.

Abstract

In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches: catalytic antibodies, computational design, directed evolution, artificial metal-cofactors and DNAzymes. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical

Mesh：

Substances：
Metalloproteins

Year: 2010 PMID： 20071213 DOI： 10.1016/j.cbpa.2009.11.026

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

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Cited

18 in total

1. Protein design: A metalloenzyme reloaded.

Authors: Birte Höcker
Journal: Nat Chem Biol Date: 2012-02-15 Impact factor: 15.040

Review 2. Optimizing non-natural protein function with directed evolution.

Authors: Eric M Brustad; Frances H Arnold
Journal: Curr Opin Chem Biol Date: 2010-12-23 Impact factor: 8.822

3. Tetrahydrofuranyl and tetrahydropyranyl protection of amino acid side-chains enables synthesis of a hydroxamate-containing aminoacylated tRNA.

Authors: Lester J Lambert; Marvin J Miller; Paul W Huber
Journal: Org Biomol Chem Date: 2015-02-28 Impact factor: 3.876

Design strategies for the creation of artificial metalloenzymes.

1. Protein design: A metalloenzyme reloaded.

Review 2. Optimizing non-natural protein function with directed evolution.

3. Tetrahydrofuranyl and tetrahydropyranyl protection of amino acid side-chains enables synthesis of a hydroxamate-containing aminoacylated tRNA.

Review 4. Design and engineering of artificial oxygen-activating metalloenzymes.

5. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.

6. Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin.

Review 7. Computational strategies for the design of new enzymatic functions.

Review 8. Metalloenzyme design and engineering through strategic modifications of native protein scaffolds.

9. Biotinylated Rh(III) complexes in engineered streptavidin for accelerated asymmetric C-H activation.

10. Orthogonal Expression of an Artificial Metalloenzyme for Abiotic Catalysis.