Literature DB >> 18687005

Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.

Daniel Grant1, Russell Dahl, Nicholas D P Cosford.   

Abstract

A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in approximately 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply.

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Year:  2008        PMID： 18687005      PMCID： PMC2801056          DOI： 10.1021/jo801152c

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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