Literature DB >> 12790603

Regiospecific synthesis of 3-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine.

Alan R Katritzky1, Yong-Jiang Xu, Hongbin Tu.   

Abstract

3-Substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine were obtained regiospecifically in yields of 35-92% in one pot by reaction of 2-aminopyridines or 2-(or 4-)aminopyrimidines, respectively, with 1,2-bis(benzotriazolyl)-1,2-(dialkylamino)ethanes.

Entities:  

Year:  2003        PMID： 12790603     DOI： 10.1021/jo026797p

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  16 in total

1.  One-pot synthesis of highly substituted N-fused heteroaromatic bicycles from azole aldehydes.

Authors:  Victor K Outlaw; Felipe B d'Andrea; Craig A Townsend
Journal:  Org Lett       Date:  2015-03-27       Impact factor: 6.005

2.  2-Amino-4-meth-oxy-6-methyl-pyrimidin-1-ium picrate.

Authors:  Jerry P Jasinski; Ray J Butcher; H S Yathirajan; B Narayana; K Prakash Kamath
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-28

3.  Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity.

Authors:  Garrett C Moraski; Lowell D Markley; Philip A Hipskind; Helena Boshoff; Sanghyun Cho; Scott G Franzblau; Marvin J Miller
Journal:  ACS Med Chem Lett       Date:  2011-06-09       Impact factor: 4.345

Review 4.  Advances in Drug Discovery and Development for Pediatric Tuberculosis.

Authors:  Daniel Hoagland; Ying Zhao; Richard E Lee
Journal:  Mini Rev Med Chem       Date:  2016       Impact factor: 3.862

5.  2-Amino-pyrimidinium picrate.

Authors:  B Narayana; B K Sarojini; K Prakash Kamath; H S Yathirajan; Michael Bolte
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

6.  4'-Methyl-3-(4-nitro-phen-yl)-4-phenyl-4,5,1',2',3',4'-hexa-hydro-spiro-[isoxazole-5,2'-naphthalen]-1'-one.

Authors:  Ghali Alhouari; Abdelali Kerbal; Najib Ben Larbi; Brahim Bennani; Taibi Ben Hadda; Helen Stoeckli-Evans
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-23

7.  Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

Authors:  Kevin Pethe; Pablo Bifani; Jichan Jang; Sunhee Kang; Seijin Park; Sujin Ahn; Jan Jiricek; Juyoung Jung; Hee Kyoung Jeon; Jonathan Cechetto; Thierry Christophe; Honggun Lee; Marie Kempf; Mary Jackson; Anne J Lenaerts; Ha Pham; Victoria Jones; Min Jung Seo; Young Mi Kim; Mooyoung Seo; Jeong Jea Seo; Dongsik Park; Yoonae Ko; Inhee Choi; Ryangyeo Kim; Se Yeon Kim; SeungBin Lim; Seung-Ae Yim; Jiyoun Nam; Hwankyu Kang; Haejin Kwon; Chun-Taek Oh; Yoojin Cho; Yunhee Jang; Junghwan Kim; Adeline Chua; Bee Huat Tan; Mahesh B Nanjundappa; Srinivasa P S Rao; Whitney S Barnes; René Wintjens; John R Walker; Sylvie Alonso; Saeyeon Lee; Jungjun Kim; Soohyun Oh; Taegwon Oh; Ulf Nehrbass; Sung-Jun Han; Zaesung No; Jinhwa Lee; Priscille Brodin; Sang-Nae Cho; Kiyean Nam; Jaeseung Kim
Journal:  Nat Med       Date:  2013-08-04       Impact factor: 53.440

8.  Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles.

Authors:  David M Arnold; Matthew G Laporte; Shelby M Anderson; Peter Wipf
Journal:  Tetrahedron       Date:  2013-09-09       Impact factor: 2.457

9.  Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

Authors:  Ananda Herath; Russell Dahl; Nicholas D P Cosford
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005

10.  Microwave assisted synthesis of bis and tris(ω-bromoacetophenones): versatile precursors for novel bis(imidazo[1,2-a]pyridines), bis(imidazo[1,2-a]pyrimidines) and their tris-analogs.

Authors:  Mohamed R Shaaban
Journal:  Chem Cent J       Date:  2013-06-19       Impact factor: 4.215
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