Literature DB >> 11149870

Efficient syntheses of imidazolo[1,2-a]pyridines and -[2, 1-a]isoquinolines.

A R Katritzky1, G Qiu, Q H Long, H Y He, P J Steel.   

Abstract

2-Aminopyridines 1a-c and 1-aminoisoquinoline with 1-chloromethylbenzotriazole give 2-amino-1-[alpha-benzotriazol-1-ylmethyl]pyridinium chlorides 2a-c and 1-amino-2-(alpha-benzotriazol-1-ylmethyl)isoquinolinium++ + chloride 12, respectively. Compounds 2a-c and 12 react with aryl aldehydes 3a-h to afford imidazolo[1,2-a]pyridines 7a-k and imidazolo[2, 1-a]isoquinolines 13a,b in good yields.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11149870     DOI： 10.1021/jo0012602

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Authors:  Zhang-Gao Le; Zong-Bo Xie; Jian-Ping Xu
Journal:  Molecules       Date:  2012-11-09       Impact factor: 4.411

2.  Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

Authors:  Ananda Herath; Russell Dahl; Nicholas D P Cosford
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.