| Literature DB >> 18314944 |
Bhooma Raghavan1, Ranganathan Balasubramanian, Jaeson C Steele, Dan L Sackett, Robert A Fecik.
Abstract
An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain significant cytotoxicity and reveal important preliminary structure-activity relationships.Entities:
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Year: 2008 PMID： 18314944 DOI： 10.1021/jm701321p
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446