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Literature DB >> 19938817

Differential ion mobility separations of peptides with resolving power exceeding 50.

Alexandre A Shvartsburg, Keqi Tang, Richard D Smith.

Abstract

Differential ion mobility spectrometry (IMS) or field asymmetric waveform IMS (FAIMS) separates gas-phase ions by mobility differences with respect to the electric field intensity. A major emerging FAIMS application is the fractionation of proteolytic digests. Using a planar FAIMS unit with helium/nitrogen mixtures, we have increased FAIMS resolving powers for peptide analyses from the prior maximum of approximately 20-30 to approximately 50-70. The resolution improved nearly 3-fold, allowing, in particular, separation of previously unresolved conformers.

Entities: Chemical Disease Gene

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Year: 2010 PMID： 19938817 PMCID： PMC2864551 DOI： 10.1021/ac902133n

Source DB: PubMed Journal: Anal Chem ISSN： 0003-2700 Impact factor: 6.986

19 in total

1. Analysis of a tryptic digest of pig hemoglobin using ESI-FAIMS-MS.

Authors: R Guevremont; D A Barnett; R W Purves; J Vandermey
Journal: Anal Chem Date: 2000-10-01 Impact factor: 6.986

2. Elongated conformers of charge states +11 to +15 of bovine ubiquitin studied using ESI-FAIMS-MS.

Authors: R W Purves; D A Barnett; B Ells; R Guevremont
Journal: J Am Soc Mass Spectrom Date: 2001-08 Impact factor: 3.109

3. Application of ESI-FAIMS-MS to the analysis of tryptic peptides.

Authors: David A Barnett; Barbara Ells; Roger Guevremont; Randy W Purves
Journal: J Am Soc Mass Spectrom Date: 2002-11 Impact factor: 3.109

4. Two-dimensional gas-phase separations coupled to mass spectrometry for analysis of complex mixtures.

Authors: Keqi Tang; Fumin Li; Alexandre A Shvartsburg; Eric F Strittmatter; Richard D Smith
Journal: Anal Chem Date: 2005-10-01 Impact factor: 6.986

5. Characterizing the structures and folding of free proteins using 2-D gas-phase separations: observation of multiple unfolded conformers.

Authors: Alexandre A Shvartsburg; Fumin Li; Keqi Tang; Richard D Smith
Journal: Anal Chem Date: 2006-05-15 Impact factor: 6.986

6. Ion mobility spectrometry-mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures.

Authors: Erin Shammel Baker; Brian H Clowers; Fumin Li; Keqi Tang; Aleksey V Tolmachev; David C Prior; Mikhail E Belov; Richard D Smith
Journal: J Am Soc Mass Spectrom Date: 2007-04-06 Impact factor: 3.109

7. Scaling of the resolving power and sensitivity for planar FAIMS and mobility-based discrimination in flow- and field-driven analyzers.

Authors: Alexandre A Shvartsburg; Richard D Smith
Journal: J Am Soc Mass Spectrom Date: 2007-06-30 Impact factor: 3.109

8. Understanding and designing field asymmetric waveform ion mobility spectrometry separations in gas mixtures.

Authors: Alexandre A Shvartsburg; Keqi Tang; Richard D Smith
Journal: Anal Chem Date: 2004-12-15 Impact factor: 6.986

9. Gaseous bradykinin and its singly, doubly, and triply protonated forms: a first-principles study.

Authors: Christopher F Rodriquez; Galina Orlova; Yuzhu Guo; Xiaomao Li; Chi-Kit Siu; Alan C Hopkinson; K W Michael Siu
Journal: J Phys Chem B Date: 2006-04-13 Impact factor: 2.991

10. Assessing the dynamic range and peak capacity of nanoflow LC-FAIMS-MS on an ion trap mass spectrometer for proteomics.

Authors: Jesse D Canterbury; Xianhua Yi; Michael R Hoopmann; Michael J MacCoss
Journal: Anal Chem Date: 2008-08-12 Impact factor: 6.986

19 in total

Differential ion mobility separations of peptides with resolving power exceeding 50.

1. Analysis of a tryptic digest of pig hemoglobin using ESI-FAIMS-MS.

2. Elongated conformers of charge states +11 to +15 of bovine ubiquitin studied using ESI-FAIMS-MS.

3. Application of ESI-FAIMS-MS to the analysis of tryptic peptides.

4. Two-dimensional gas-phase separations coupled to mass spectrometry for analysis of complex mixtures.

5. Characterizing the structures and folding of free proteins using 2-D gas-phase separations: observation of multiple unfolded conformers.

6. Ion mobility spectrometry-mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures.

7. Scaling of the resolving power and sensitivity for planar FAIMS and mobility-based discrimination in flow- and field-driven analyzers.

8. Understanding and designing field asymmetric waveform ion mobility spectrometry separations in gas mixtures.

9. Gaseous bradykinin and its singly, doubly, and triply protonated forms: a first-principles study.

10. Assessing the dynamic range and peak capacity of nanoflow LC-FAIMS-MS on an ion trap mass spectrometer for proteomics.

1. Accelerated high-resolution differential ion mobility separations using hydrogen.

2. Conformational distribution of bradykinin [bk + 2 H]2+ revealed by cold ion spectroscopy coupled with FAIMS.

3. Separation and classification of lipids using differential ion mobility spectrometry.

4. Pushing the Frontier of High-Definition Ion Mobility Spectrometry Using FAIMS.

Review 5. Size, weight and position: ion mobility spectrometry and imaging MS combined.

6. Improved Differential Ion Mobility Separations Using Linked Scans of Carrier Gas Composition and Compensation Field.

7. Variables Affecting the Internal Energy of Peptide Ions During Separation by Differential Ion Mobility Spectrometry.

8. Separation of a set of peptide sequence isomers using differential ion mobility spectrometry.

9. Optimization of peptide separations by differential ion mobility spectrometry.

10. High-definition differential ion mobility spectrometry with resolving power up to 500.