Literature DB >> 21863819

Separation of a set of peptide sequence isomers using differential ion mobility spectrometry.

Alexandre A Shvartsburg, Andrew J Creese, Richard D Smith, Helen J Cooper.   

Abstract

Protein identification in bottom-up proteomics requires disentangling isomers of proteolytic peptides, a major class of which are sequence inversions. Their separation using ion mobility spectrometry (IMS) has been limited to isomeric pairs. Here we demonstrate baseline separation of all seven 8-mer tryptic peptide isomers using differential IMS. Evaluation of peak capacity implies that even larger libraries should be resolved for heavier peptides with higher charge states.

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Year:  2011        PMID： 21863819      PMCID： PMC3173593          DOI： 10.1021/ac201640d

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  31 in total

1.  Separation of isomeric peptides using electrospray ionization/high-resolution ion mobility spectrometry.

Authors:  C Wu; W F Siems; J Klasmeier; H H Hill
Journal:  Anal Chem       Date:  2000-01-15       Impact factor: 6.986

2.  A database of 660 peptide ion cross sections: use of intrinsic size parameters for bona fide predictions of cross sections.

Authors:  S J Valentine; A E Counterman; D E Clemmer
Journal:  J Am Soc Mass Spectrom       Date:  1999-11       Impact factor: 3.109

3.  Resolving isomeric peptide mixtures: a combined HPLC/ion mobility-TOFMS analysis of a 4000-component combinatorial library.

Authors:  BarnesCatherineA Srebalus; Amy E Hilderbrand; Stephen J Valentine; David E Clemmer
Journal:  Anal Chem       Date:  2002-01-01       Impact factor: 6.986

4.  Prediction of peptide ion mobilities via a priori calculations from intrinsic size parameters of amino acid residues.

Authors:  A A Shvartsburg; K W Siu; D E Clemmer
Journal:  J Am Soc Mass Spectrom       Date:  2001-08       Impact factor: 3.109

Review 5.  Proteomic analysis of post-translational modifications.

Authors:  Matthias Mann; Ole N Jensen
Journal:  Nat Biotechnol       Date:  2003-03       Impact factor: 54.908

6.  Application of ESI-FAIMS-MS to the analysis of tryptic peptides.

Authors:  David A Barnett; Barbara Ells; Roger Guevremont; Randy W Purves
Journal:  J Am Soc Mass Spectrom       Date:  2002-11       Impact factor: 3.109

Review 7.  High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry.

Authors:  Roger Guevremont
Journal:  J Chromatogr A       Date:  2004-11-26       Impact factor: 4.759

8.  Gas-phase separations of electrosprayed peptide libraries.

Authors:  C A Srebalus; J Li; W S Marshall; D E Clemmer
Journal:  Anal Chem       Date:  1999-09-15       Impact factor: 6.986

9.  Gas-phase conformers of the [M + 2H](2+) ion of bradykinin investigated by combining high-field asymmetric waveform ion mobility spectrometry, hydrogen/deuterium exchange, and energy-loss measurements.

Authors:  R W Purves; D A Barnett; B Ells; R Guevremont
Journal:  Rapid Commun Mass Spectrom       Date:  2001       Impact factor: 2.419

10.  Peak capacity of ion mobility mass spectrometry: the utility of varying drift gas polarizability for the separation of tryptic peptides.

Authors:  Brandon T Ruotolo; John A McLean; Kent J Gillig; David H Russell
Journal:  J Mass Spectrom       Date:  2004-04       Impact factor: 1.982
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  21 in total

1.  Accelerated high-resolution differential ion mobility separations using hydrogen.

Authors:  Alexandre A Shvartsburg; Richard D Smith
Journal:  Anal Chem       Date:  2011-11-10       Impact factor: 6.986

2.  Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry.

Authors:  Zhidan Chen; Stephen L Coy; Evan L Pannkuk; Evagelia C Laiakis; Adam B Hall; Albert J Fornace; Paul Vouros
Journal:  J Am Soc Mass Spectrom       Date:  2016-07-08       Impact factor: 3.109

3.  Pushing the Frontier of High-Definition Ion Mobility Spectrometry Using FAIMS.

Authors:  Alexandre A Shvartsburg; Gordon A Anderson; Richard D Smith
Journal:  Mass Spectrom (Tokyo)       Date:  2013-04-15

4.  Improved Differential Ion Mobility Separations Using Linked Scans of Carrier Gas Composition and Compensation Field.

Authors:  Brandon G Santiago; Rachel A Harris; Samantha L Isenberg; Mark E Ridgeway; Alice L Pilo; Desmond A Kaplan; Gary L Glish
Journal:  J Am Soc Mass Spectrom       Date:  2015-07-07       Impact factor: 3.109

5.  Separation of opiate isomers using electrospray ionization and paper spray coupled to high-field asymmetric waveform ion mobility spectrometry.

Authors:  Nicholas E Manicke; Michael Belford
Journal:  J Am Soc Mass Spectrom       Date:  2015-03-24       Impact factor: 3.109

6.  Variables Affecting the Internal Energy of Peptide Ions During Separation by Differential Ion Mobility Spectrometry.

Authors:  Brandon G Santiago; Matthew T Campbell; Gary L Glish
Journal:  J Am Soc Mass Spectrom       Date:  2017-06-26       Impact factor: 3.109

Review 7.  Protein analysis by shotgun/bottom-up proteomics.

Authors:  Yaoyang Zhang; Bryan R Fonslow; Bing Shan; Moon-Chang Baek; John R Yates
Journal:  Chem Rev       Date:  2013-02-26       Impact factor: 60.622

8.  Description of gas-phase ion/neutral interactions in differential ion mobility spectrometry: CV prediction using calibration runs.

Authors:  David Auerbach; Julia Aspenleiter; Dietrich A Volmer
Journal:  J Am Soc Mass Spectrom       Date:  2014-06-14       Impact factor: 3.109

9.  High-resolution differential ion mobility spectrometry of a protein.

Authors:  Alexandre A Shvartsburg; Richard D Smith
Journal:  Anal Chem       Date:  2012-12-17       Impact factor: 6.986

10.  Optimization of peptide separations by differential ion mobility spectrometry.

Authors:  Samantha L Isenberg; Paul M Armistead; Gary L Glish
Journal:  J Am Soc Mass Spectrom       Date:  2014-07-03       Impact factor: 3.109
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