Literature DB >> 19936926

Flow visualization of three-dimensionality inside the 12 cc Penn State pulsatile pediatric ventricular assist device.

Breigh N Roszelle1, Steven Deutsch, Keefe B Manning.   

Abstract

In order to aid the ongoing concern of limited organ availability for pediatric heart transplants, Penn State has continued development of a pulsatile Pediatric Ventricular Assist Device (PVAD). Initial studies of the PVAD observed an increase in thrombus formation due to differences in flow field physics when compared to adult sized devices, which included a higher degree of three-dimensionality. This unique flow field brings into question the use of 2D planar particle image velocimetry (PIV) as a flow visualization technique, however the small size and high curvature of the PVAD make other tools such as stereoscopic PIV impractical. In order to test the reliability of the 2D results, we perform a pseudo-3D PIV study using planes both parallel and normal to the diaphragm employing a mock circulatory loop containing a viscoelastic fluid that mimics 40% hematocrit blood. We find that while the third component of velocity is extremely helpful to a physical understanding of the flow, particularly of the diastolic jet and the development of a desired rotational pattern, the flow data taken parallel to the diaphragm is sufficient to describe the wall shear rates, a critical aspect to the study of thrombosis and design of such pumps.

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Year:  2010        PMID: 19936926      PMCID: PMC2882698          DOI: 10.1007/s10439-009-9842-7

Source DB:  PubMed          Journal:  Ann Biomed Eng        ISSN: 0090-6964            Impact factor:   3.934


  17 in total

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Authors:  M Beghetti; P C Rimensberger
Journal:  Intensive Care Med       Date:  2000-03       Impact factor: 17.440

2.  Fluid dynamics of a pediatric ventricular assist device.

Authors:  C Bachmann; G Hugo; G Rosenberg; S Deutsch; A Fontaine; J M Tarbell
Journal:  Artif Organs       Date:  2000-05       Impact factor: 3.094

3.  Wall shear-rate estimation within the 50cc Penn State artificial heart using particle image velocimetry.

Authors:  Pramote Hochareon; Keefe B Manning; Arnold A Fontaine; John M Tarbell; Steven Deutsch
Journal:  J Biomech Eng       Date:  2004-08       Impact factor: 2.097

4.  Validation of the orifice formula for estimating effective heart valve opening area.

Authors:  T Cochrane; C J Kenyon; P V Lawford; M M Black; J B Chambers; D C Sprigings
Journal:  Clin Phys Physiol Meas       Date:  1991-02

5.  The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program.

Authors:  J Timothy Baldwin; Harvey S Borovetz; Brian W Duncan; Mark J Gartner; Robert K Jarvik; William J Weiss; Tracey R Hoke
Journal:  Circulation       Date:  2006-01-03       Impact factor: 29.690

6.  Correlation of in vivo clot deposition with the flow characteristics in the 50 cc penn state artificial heart: a preliminary study.

Authors:  Pramote Hochareon; Keefe B Manning; Arnold A Fontaine; John M Tarbell; Steven Deutsch
Journal:  ASAIO J       Date:  2004 Nov-Dec       Impact factor: 2.872

7.  Effect of the diastolic and systolic duration on valve cavitation in a pediatric pulsatile ventricular assist device.

Authors:  Branka Lukic; Conrad M Zapanta; Kimberly A Griffith; William J Weiss
Journal:  ASAIO J       Date:  2005 Sep-Oct       Impact factor: 2.872

8.  The 50cc Penn State left ventricular assist device: a parametric study of valve orientation flow dynamics.

Authors:  James W Kreider; Keefe B Manning; Leslie A Oley; Arnold A Fontaine; Steven Deutsch
Journal:  ASAIO J       Date:  2006 Mar-Apr       Impact factor: 2.872

9.  LDA measurements of mean velocity and Reynolds stress fields within an artificial heart ventricle.

Authors:  J T Baldwin; S Deutsch; D B Geselowitz; J M Tarbell
Journal:  J Biomech Eng       Date:  1994-05       Impact factor: 2.097

10.  Determinants of success in pediatric cardiac patients undergoing extracorporeal membrane oxygenation.

Authors:  M D Black; J G Coles; W G Williams; I M Rebeyka; G A Trusler; D Bohn; C Gruenwald; R M Freedom
Journal:  Ann Thorac Surg       Date:  1995-07       Impact factor: 4.330

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  6 in total

1.  Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices: Application of a Novel Fluid-Structure Interaction-Based Strategy to the Penn State 12 cc Device.

Authors:  Alessandro Caimi; Francesco Sturla; Bryan Good; Marco Vidotto; Rachele De Ponti; Filippo Piatti; Keefe B Manning; Alberto Redaelli
Journal:  J Biomech Eng       Date:  2017-08-01       Impact factor: 2.097

Review 2.  Recent advances in computational methodology for simulation of mechanical circulatory assist devices.

Authors:  Alison L Marsden; Yuri Bazilevs; Christopher C Long; Marek Behr
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2014-01-21

3.  Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning.

Authors:  Breigh N Roszelle; Steven Deutsch; William J Weiss; Keefe B Manning
Journal:  Ann Biomed Eng       Date:  2011-03-15       Impact factor: 3.934

4.  The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device.

Authors:  Markus Schönberger; Steven Deutsch; Keefe B Manning
Journal:  ASAIO J       Date:  2012 Sep-Oct       Impact factor: 2.872

5.  Dynamics of Blood Flows in Aortic Stenosis: Mild, Moderate, and Severe.

Authors:  Choon-Sik Jhun; Raymond Newswanger; Joshua P Cysyk; Sailahari Ponnaluri; Bryan Good; Keefe B Manning; Gerson Rosenberg
Journal:  ASAIO J       Date:  2021-06-01       Impact factor: 3.826

6.  Methods for determination of stagnation in pneumatic ventricular assist devices.

Authors:  Damian Obidowski; Piotr Reorowicz; Dariusz Witkowski; Krzysztof Sobczak; Krzysztof Jóźwik
Journal:  Int J Artif Organs       Date:  2018-08-03       Impact factor: 1.595

  6 in total

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