Literature DB >> 19913541

The molecular clockwork of a protein-based circadian oscillator.

Joseph S Markson1, Erin K O'Shea.   

Abstract

The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is governed by a core oscillator consisting of the proteins KaiA, KaiB, and KaiC. Remarkably, circadian oscillations in the phosphorylation state of KaiC can be reconstituted in a test tube by mixing the three Kai proteins and adenosine triphosphate. The in vitro oscillator provides a well-defined system in which experiments can be combined with mathematical analysis to understand the mechanism of a highly robust biological oscillator. In this Review, we summarize the biochemistry of the Kai proteins and examine models that have been proposed to explain how oscillations emerge from the properties of the oscillator's constituents.

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Year:  2009        PMID： 19913541      PMCID： PMC2810098          DOI： 10.1016/j.febslet.2009.11.021

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  57 in total

1.  Independence of circadian timing from cell division in cyanobacteria.

Authors:  T Mori; C H Johnson
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

2.  Circadian clock-protein expression in cyanobacteria: rhythms and phase setting.

Authors:  Y Xu; T Mori; C H Johnson
Journal:  EMBO J       Date:  2000-07-03       Impact factor: 11.598

3.  Circadian clock protein KaiC forms ATP-dependent hexameric rings and binds DNA.

Authors:  Tetsuya Mori; Sergei V Saveliev; Yao Xu; Walter F Stafford; Michael M Cox; Ross B Inman; Carl H Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-11       Impact factor: 11.205

Review 4.  Computational approaches to cellular rhythms.

Authors:  Albert Goldbeter
Journal:  Nature       Date:  2002-11-14       Impact factor: 49.962

5.  Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism.

Authors:  Stanly B Williams; Ioannis Vakonakis; Susan S Golden; Andy C LiWang
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-15       Impact factor: 11.205

6.  Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the kaiBC promoter in regulating KaiC.

Authors:  Yao Xu; Tetsuya Mori; Carl Hirschie Johnson
Journal:  EMBO J       Date:  2003-05-01       Impact factor: 11.598

7.  NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: implications for KaiA-KaiC interaction.

Authors:  Ioannis Vakonakis; Jingchuan Sun; Tianfu Wu; Andreas Holzenburg; Susan S Golden; Andy C LiWang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-28       Impact factor: 11.205

Review 8.  Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.

Authors:  John J Tyson; Katherine C Chen; Bela Novak
Journal:  Curr Opin Cell Biol       Date:  2003-04       Impact factor: 8.382

9.  Predicting regulation of the phosphorylation cycle of KaiC clock protein using mathematical analysis.

Authors:  Hisako Takigawa-Imamura; Atsushi Mochizuki
Journal:  J Biol Rhythms       Date:  2006-10       Impact factor: 3.182

10.  ATP-induced hexameric ring structure of the cyanobacterial circadian clock protein KaiC.

Authors:  Fumio Hayashi; Hirofumi Suzuki; Ryo Iwase; Tatsuya Uzumaki; Asako Miyake; Jian-Ren Shen; Katsumi Imada; Yukio Furukawa; Koji Yonekura; Keiichi Namba; Masahiro Ishiura
Journal:  Genes Cells       Date:  2003-03       Impact factor: 1.891
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  24 in total

1.  NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed.

Authors:  Joanna C Chiu; Hyuk Wan Ko; Isaac Edery
Journal:  Cell       Date:  2011-04-29       Impact factor: 41.582

2.  Synchronization of circadian oscillation of phosphorylation level of KaiC in vitro.

Authors:  Tetsuro Nagai; Tomoki P Terada; Masaki Sasai
Journal:  Biophys J       Date:  2010-06-02       Impact factor: 4.033

3.  Robust circadian clocks from coupled protein-modification and transcription-translation cycles.

Authors:  David Zwicker; David K Lubensky; Pieter Rein ten Wolde
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-13       Impact factor: 11.205

4.  Chlamydomonas reinhardtii: duration of its cell cycle and phases at growth rates affected by light intensity.

Authors:  Milada Vítová; Kateřina Bišová; Dáša Umysová; Monika Hlavová; Shigeyuki Kawano; Vilém Zachleder; Mária Cížková
Journal:  Planta       Date:  2010-10-05       Impact factor: 4.116

5.  Circadian control of global gene expression by the cyanobacterial master regulator RpaA.

Authors:  Joseph S Markson; Joseph R Piechura; Anna M Puszynska; Erin K O'Shea
Journal:  Cell       Date:  2013-12-05       Impact factor: 41.582

Review 6.  Understanding systems-level properties: timely stories from the study of clocks.

Authors:  John B Hogenesch; Hiroki R Ueda
Journal:  Nat Rev Genet       Date:  2011-05-10       Impact factor: 53.242

Review 7.  Temporal and spatial oscillations in bacteria.

Authors:  Peter Lenz; Lotte Søgaard-Andersen
Journal:  Nat Rev Microbiol       Date:  2011-08-15       Impact factor: 60.633

Review 8.  The itty-bitty time machine genetics of the cyanobacterial circadian clock.

Authors:  Shannon R Mackey; Susan S Golden; Jayna L Ditty
Journal:  Adv Genet       Date:  2011       Impact factor: 1.944

9.  Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.

Authors:  Evrim Yildirim; Joanna C Chiu; Isaac Edery
Journal:  Mol Cell Biol       Date:  2015-12-28       Impact factor: 4.272

10.  Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock.

Authors:  Martin Egli; Rekha Pattanayek; Jonathan H Sheehan; Yao Xu; Tetsuya Mori; Jarrod A Smith; Carl H Johnson
Journal:  Biochemistry       Date:  2013-02-07       Impact factor: 3.162
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