Literature DB >> 12648679

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.

John J Tyson1, Katherine C Chen, Bela Novak.   

Abstract

The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.

Mesh:

Year:  2003        PMID: 12648679     DOI: 10.1016/s0955-0674(03)00017-6

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN: 0955-0674            Impact factor:   8.382


  484 in total

1.  Design of genetic networks with specified functions by evolution in silico.

Authors:  Paul François; Vincent Hakim
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-02       Impact factor: 11.205

2.  Structure and function of the feed-forward loop network motif.

Authors:  S Mangan; U Alon
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-06       Impact factor: 11.205

3.  Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction.

Authors:  Esti Yeger-Lotem; Shmuel Sattath; Nadav Kashtan; Shalev Itzkovitz; Ron Milo; Ron Y Pinter; Uri Alon; Hanah Margalit
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-12       Impact factor: 11.205

4.  Gene dosage balance in cellular pathways: implications for dominance and gene duplicability.

Authors:  Reiner A Veitia
Journal:  Genetics       Date:  2004-09       Impact factor: 4.562

Review 5.  Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis.

Authors:  Maria Rosa Domingo-Sananes; Orsolya Kapuy; Tim Hunt; Bela Novak
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-12-27       Impact factor: 6.237

6.  Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic.

Authors:  Charlotte A Dodson; Richard Bayliss
Journal:  J Biol Chem       Date:  2011-11-16       Impact factor: 5.157

7.  Quantitative modeling of the terminal differentiation of B cells and mechanisms of lymphomagenesis.

Authors:  María Rodríguez Martínez; Alberto Corradin; Ulf Klein; Mariano Javier Álvarez; Gianna M Toffolo; Barbara di Camillo; Andrea Califano; Gustavo A Stolovitzky
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

8.  Integrating multiple signals into cell decisions by networks of protein modification cycles.

Authors:  Luca Cerone; Javier Muñoz-Garcia; Zoltán Neufeld
Journal:  Biophys J       Date:  2011-10-05       Impact factor: 4.033

9.  Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution.

Authors:  Ping Ao; David Galas; Leroy Hood; Xiaomei Zhu
Journal:  Med Hypotheses       Date:  2007-09-04       Impact factor: 1.538

10.  Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype.

Authors:  Joseph J Boyle; Heather A Harrington; Emma Piper; Kay Elderfield; Jaroslav Stark; Robert C Landis; Dorian O Haskard
Journal:  Am J Pathol       Date:  2009-03       Impact factor: 4.307

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