Preoperative and early postoperative quality of life predict survival in potentially curable patients with esophageal cancer.

BACKGROUND: In patients with esophageal cancer, evidence for prognostic significance of preoperative quality of life (QoL) is limited, while the prognostic significance of postoperative QoL has not been investigated at all. AIM: To determine whether preoperative and postoperative QoL measurements can predict survival independently from clinical and pathological factors, in patients with potentially curable esophageal adenocarcinoma.
METHODS: A randomized controlled trial was performed from 1994 to 2000 in two academic medical centres, comparing transthoracic and transhiatal esophagectomy. QoL questionnaires were sent before and 3 months after surgery (Medical Outcome Study Short Form-20 and Rotterdam Symptom Checklist). Uni- and multivariate Cox regression analyses were used to examine firstly the prognostic value of preoperative QoL and several clinical factors, and secondly of postoperative QoL, several clinical factors, and pathological staging.
RESULTS: Out of 220 randomized patients, 199 participated in the QoL-study. In the multivariate preoperative model physical symptom scale (p = 0.021), tumor length (p = 0.034), and endosonographic T-stage (p = 0.003) were predictive for overall survival. In the postoperative multivariate analysis, social functioning (p = 0.035), pain (p = 0.026), and activity level (p = 0.037) predicted survival, besides pathological T-stage (p < 0.001) and N-stage (p < 0.001).
CONCLUSION: In the present paper the first large consecutive series of potentially curable esophageal cancer patients is presented in whom prospectively collected QoL data before and after potentially curative surgical resection were used to predict survival. Both preoperative (physical symptoms) and postoperative (social functioning, pain, and activity level) QoL subscales are independent predictors of survival in potentially curable patients with esophageal adenocarcinoma.

RCT Entities:   Population Interventions Outcomes

Surgery is considered to be the best curative treatment for patients with advanced esophageal cancer, whether or not preceded by neoadjuvant therapy.1 Despite many improvements in oncological treatment and perioperative care, survival remains poor.2 Even after potentially curative esophagectomy 5-year survival rates rarely exceed 40%.3–5 Long-term survival depends on several factors including well-known clinical and pathological parameters.6 Prediction of long-term survival is of great importance because a major proportion of patients want a realistic and individualized approach from the cancer specialist when discussing their prognosis.7,8

Recently, patient-reported outcomes have been studied as prognostic factors for survival in oncological patients.9 In these studies pretreatment quality of life (QoL) has been shown to be significantly associated with survival in various types of cancer patients, such as those with colorectal, breast, prostate, and lung cancer.10–13 However, for patients with esophageal cancer, solid evidence for prognostic significance of preoperative QoL is still limited.14–16 The prognostic value of posttreatment QoL for this group of cancer patients has not been investigated at all.

The aim of the present study is to examine to what extent pre- and postoperative QoL subscales are able to predict survival, independently from well-known clinical and pathological prognostic factors, in a large homogeneous series of patients with potentially curable esophageal adenocarcinoma.

Patients and Methods

Patients

Eligible patients with histologically confirmed adenocarcinoma of the distal esophagus or gastric cardia substantially involving the distal esophagus without evidence of distant dissemination and/or local irresectability were randomly assigned to undergo transhiatal esophagectomy or transthoracic esophagectomy with extended en bloc lymphadenectomy. Patients were included between April 1994 and February 2000, in two academic medical centres. The study was approved by the medical ethics committees. Patients were older than 18 years and in adequate condition as indicated by their assignment to American Society of Anesthesiologists (ASA) class I or II.17 Exclusion criteria were previous or coexisting cancer, neoadjuvant chemotherapy or radiation therapy, recurrent laryngeal nerve palsy, and the impossibility to construct a gastric tube. Details of design, surgical technique, and clinical results of this trial have been reported earlier.4,18 Summarizing the most important results of this trial, transhiatal esophagectomy proved to be associated with lower morbidity than transthoracic esophagectomy with extended en bloc lymphadenectomy. There was no significant overall survival benefit for either approach, but compared with limited transhiatal resection, extended transthoracic esophagectomy for type I esophageal adenocarcinoma showed an ongoing trend towards better 5-year survival. Moreover, patients with a limited number of positive lymph nodes in the resection specimen seemed to benefit from an extended transthoracic esophagectomy. Clinical data was collected prospectively.

Quality-of-Life Measurement

QoL data were gathered by using self-administered QoL questionnaires, which were sent to the patients before and 3 months after surgery. If the patient did not return the questionnaire, he or she received one reminder.

Generic QoL was measured with the Medical Outcome Study Short Form-20 (MOS SF-20), a reliable and valid standardized measure containing 20 items measuring health perceptions, physical functioning, role functioning, social functioning, mental health, energy, and bodily pain.19 The MOS SF-20 was scored on a five-point scale. All raw scales were linearly converted to a 0–100 scale, with higher scores indicating better QoL, except for bodily pain where a higher score indicated more pain.

Disease-specific QoL was measured by the Rotterdam Symptom Checklist (RSCL), an extensively validated self-report questionnaire designed for use with cancer patients.20,21 We adapted the original RSCL by adding nine physical symptoms specific to esophageal carcinoma (dysphagia, loss of taste, weight loss, early satiety, blown-up feeling, hoarseness, pain behind chest bone, food not going down, and nocturnal coughing) and omitting seven less relevant physical items (burning eyes, dry mouth, hair loss, shivering, tingling hands or feet, painful muscles, and lower back pain).22 The adapted RSCL contained 41 items, covering 25 physical symptom items, 7 psychological symptom items, 8 items on activity level, and 1 item measuring global QoL. Answers were rated on a four-point response scale, except for the global QoL item, which was assessed on a seven-point scale. All raw scales were linearly converted to a 0–100 scale, with higher scores indicating better QoL.

Follow-Up

All patients were seen at the outpatient clinic at intervals of 3–4 months during the first 2 years and every 6 months for 3 more years. After 5 years, follow-up data were obtained by telephone from the patients or his or her family practitioner. The last check on follow-up of all patients was performed in February 2005. Recurrence of disease was diagnosed on clinical grounds. However, whenever a relapse was suspected, radiologic, endoscopic or histologic confirmation was sought.

Statistical Analysis

Survival times were calculated from time of randomization to time of death from any cause or time to last follow-up visit (at which time data were censored). Disease-free survival was counted up to time of first relapse and patients were censored at time of their last visit or when they died of non-disease-related causes without previous relapse. Survival curves were constructed by the Kaplan–Meier method.

In the first part of the statistical analysis, univariate Cox regression analysis was performed using all preoperative QoL subscales and several well-known preoperative clinical factors including age, sex, tumor length, weight loss, and endosonographic tumor–node–metastasis (TNM) stage (uTNM). All variables with p < 0.05 were included in multivariate analysis. Using backward elimination a final multivariate model was created keeping only variables with p < 0.05. In case there was the problem of monotone likelihood because of zero events in any of the strata of the predictors, Cox regression analysis with Firth penalization was used.23 Cox regression analysis was performed for overall and disease-free survival. Since pathological stage is not available preoperatively, we included only clinical factors actually available preoperatively in this part of the analysis.

The second part of the analysis was performed in the same manner, now using the postoperative QoL subscales, and pathological TNM stage of the resection specimen instead of endosonographical TNM stage. We deliberately chose not to analyze all QoL items separately and only to use subscales, to reduce chance-related findings. Statistical analysis was performed with the Statistical Package for the Social Sciences software version 15.0 (SPSS, Chicago, IL).

Results

Between April 1994 and February 2000, 220 patients were randomized for transhiatal or transthoracic esophagectomy. A total of 199 patients agreed to participate in the QoL study. Fourteen patients were enrolled into the study before the quality-of-life substudy had started, and seven patients were not sent baseline questionnaires because of an administrative error. Patient characteristics are summarized in Table 1. Preoperative QoL-questionnaires were returned by 187 patients (94.0%). The QoL questionnaires sent 3 months postoperatively were returned by 178 of the 199 participating patients (89.4%); the remaining 9 patients (4.5%) deceased within 3 months of surgery.

Table 1

Clinicopathological characteristics of patients undergoing potentially curative esophagectomy

	All patients (n = 199)
Age in years (median) [range]	64 [35–78]
Sex (male/female)	173/26
Tumor length in cm (median) [range]	4 [1–12]
Weight loss (kg) [range]	4 [–7 to 27]
Transhiatal versus transthoracic	93 (47%)/106 (53%)
Pathological T-stage
T1	35 (17.6%)
T2	23 (11.6%)
T3	141 (70.9)
T4	0 (0%)
Pathological N-stage
N0	55 (27.6%)
N1	144 (72.4%)
Returned preoperative questionnaire	187 (94.0%)
Returned postoperative questionnaire	178 (89.4%)

In all patients, the operation was performed at least 5 years earlier, ensuring a minimal potential follow-up of 5 years (range 5–10.6 years). Overall 5-year survival was 35.5% and 5-year disease-free survival was 32.6% (Fig. 1a, b).

Fig. 1

a Overall survival of all patients undergoing potentially curative esophagectomy. b Disease-free survival of all patients undergoing potentially curative esophagectomy

All of the median QoL subscale scores decreased or remained unchanged after surgery, except for RSCL psychological symptoms (Table 2).

Table 2

Pre- and postoperative quality of life scores (median and interquartile range) in patients undergoing potentially curative esophagectomy

	Preoperative QoL (N = 187)	QoL score 3 months after surgery (N = 178)
SF-20 physical functioning	83 [50–100]	42 [26–67]
SF-20 health perception	50 [35–70]	42 [32–65]
SF-20 social functioning	100 [60–100]	74 [46–100]
SF-20 energy	72 [60–85]	55 [40–75]
SF-20 pain	25 [0–50]	25 [0–50]
SF-20 role functioning	100 [50–100]	38 [0–100]
SF-20 mental health	76 [64–88]	76 [60–92]
RSCL physical symptoms	84 [80–92]	77 [69–85]
RSCL activity level	100 [93–100]	92 [76–100]
RSCL psychological symptoms	76 [62–90]	81 [71–95]
RSCL global quality of life	67 [50–83]	67 [50–83]

SF-20 medical outcomes study short form, RSCL Rotterdam symptom checklist

On univariate Cox regression analysis of preoperative QoL scores only RSCL physical symptoms [hazard ratio (HR) 0.654; p = 0.010] and RSCL activity level (HR 0.710; p = 0.033) proved significantly predictive for overall survival (Table 3). Weight loss (HR 1.037; p = 0.004), tumor length (HR 1.141; p < 0.001), and endosonographic T-stage (T1 versus T3 HR 0.035; p = 0.001 and T2 versus T3 HR 0.805; p = 0.333) were the clinical factors predictive for overall survival in univariate analysis. Endosonographic N-stage (HR 1.155; p = 0.263) appeared not to be a predictive factor for overall survival. After backward elimination, RSCL physical symptoms (HR 0.668; p = 0.021), tumor length (HR 1.082; p = 0.034), and endosonographic T-stage (T1 versus T3 HR 0.050; p = 0.003 and T2 versus T3 HR 0.912; p = 0.717) remained independent prognostic factors in the final multivariate Cox regression model for the preoperative situation (Table 4).

Table 3

Univariate Cox regression analysis of pre- and postoperative risk factors for overall and disease-free survival in patients undergoing potentially curative esophagectomy

QoL	Overall survival				Disease-free survival
	Preoperative QoL (N = 187)		QoL 3 months after surgery (N = 178)		Preoperative QoL (N = 187)		QoL 3 months after surgery (N = 178)
	HRa (95% CI)	P value	HRa (95% CI)	P value	HRb (95% CI)	P value	HRb (95% CI)	P value
SF-20 physical functioning	0.961 (0.869–1.083)	0.510	0.887 (0.770–1.000)	0.066	0.942 (0.834–1.062)	0.374	0.869 (0.754–1.000)	0.046
SF-20 health perception	0.961 (0.835–1.127)	0.669	0.835 (0.710–0.980)	0.027	0.961 (0.835–1.127)	0.656	0.835 (0.695–0.980)	0.030
SF-20 social functioning	0.942 (0.835–1.062)	0.361	0.887 (0.770–0.961)	0.011	0.980 (0.852–1.127)	0.736	0.887 (0.785–1.000)	0.058
SF-20 energy	1.062 (0.887–1.269)	0.522	0.785 (0.654–0.923)	0.006	1.041 (0.852–1.245)	0.739	0.785 (0.641–0.942)	0.009
SF-20 pain	1.020 (0.905–1.173)	0.717	1.196 (1.062–1.374)	0.006	1.041 (0.905–1.220)	0.499	1.245 (1.083–1.429)	0.002
SF-20 role functioning	0.961 (0.887–1.041)	0.396	0.923 (0.852–1.020)	0.097	0.942 (0.869–1.041)	0.231	0.923 (0.852–1.020)	0.113
SF-20 mental health	1.062 (0.869–1.269)	0.562	0.818 (0.681–0.980)	0.030	1.020 (0.835–1.245)	0.867	0.818 (0.681–1.000)	0.044
RSCL physical symptoms	0.654 (0.480–0.905)	0.010	0.724 (0.555–0.942)	0.017	0.641 (0.461–0.905)	0.012	0.710 (0.543–0.942)	0.016
RSCL activity level	0.710 (0.522–0.980)	0.033	0.710 (0.603–0.835)	<0.001	0.695 (0.490–0.980)	0.038	0.695 (0.590–0.835)	<0.001
RSCL psychological symptoms	0.980 (0.835–1.150)	0.879	0.835 (0.695–1.000)	0.055	0.942 (0.785–1.105)	0.457	0.835 (0.681–1.000)	0.059
RSCL global quality of life	0.905 (0.770–1.062)	0.247	0.770 (0.641–0.923)	0.004	0.869 (0.724–1.062)	0.162	0.770 (0.641–0.942)	0.008
Clinical
Age [years]	0.991 (0.974–1.009)	0.311	0.995 (0.976–1.015)	0.640	0.994 (0.975–1.013)	0.547	0.994 (0.975–1.013)	0.547
Sex (male/female)	1.245 (0.740–2.097)	0.409	1.326 (0.745–2.361)	0.337	1.386 (0.762–2.519)	0.285	1.386 (0.762–2.519)	0.285
Weight loss [kg]	1.037 (1.011–1.064)	0.004	1.033 (1.005–1.062)	0.019	1.044 (1.017–1.072)	0.001	1.044 (1.017–1.072)	0.001
Tumor length [cm]	1.141 (1.074–1.212)	<0.001	1.138 (1.067–1.213)	<0.001	1.159 (1.085–1.237)	<0.001	1.159 (1.085–1.237)	<0.001
uT-stage
T1 vs. T3	0.035 (0.005–0.252)	0.001	NA		0.020 (0.0002–0.140)	<0.001	NA
T2 vs. T3	0.805 (0.519–1.248)	0.333	NA		0.868 (0.538–1.348)	0.540	NA
uN-stage (N1 vs. N0)	1.155 (0.897–1.486)	0.263	NA		1.083 (0.821–1.429)	0.571	NA
pT-stage
T1 vs. T3	NA		0.084 (0.034–0.207)	<0.001	NA		0.061 (0.019–0.192)	<0.001
T2 vs. T3	NA		0.487 (0.274–0.865)	0.014	NA		0.469 (0.245–0.899)	0.022
pN-stage (N1 vs. N0)	NA		4.617 (2.802–7.609)	<0.001	NA		5.692 (3.180–10.186)	<0.001

HR hazard ratio, CI confidence interval, u ultrasonographical, p pathological, NA not applicable, SF-20 medical outcomes study short form, RSCL Rotterdam symptom checklist

aHazard ratio provides the likelihood of death for a patient with a score of 20 points more than another patient

bHazard ratio provides the likelihood of recurrent disease for a patient with a score of 20 points more than another patient

All variables with a p-value < 0.05 were made bold

Table 4

Multivariate backward elimination Cox regression model of pre- and postoperative risk factors for overall and disease-free survival in patients undergoing potentially curative esophagectomy

QoL	Overall survival				Disease-free survival
	Preoperative QoL (N = 187)		QoL 3 months after surgery (N = 178)		Preoperative QoL (N = 187)		QoL 3 months after surgery (N = 178)
	HRa (95% CI)	P value	HRa (95% CI)	P value	HRb (95% CI)	P value	HRb (95% CI)	P value
SF-20 physical functioning	Not in model		Not in model		Not in model		Not in model
SF-20 health perception	Not in model		Not in model		not in model		Not in model
SF-20 social functioning	Not in model		0.835 (0.710–0.980)	0.035	Not in model		Not in model
SF-20 energy	Not in model		Not in model		Not in model		Not in model
SF-20 pain	Not in model		1.196 (1.020–1.401)	0.026	Not in model		1.321 (1.006–1.022)	0.001
SF-20 role functioning	Not in model		Not in model		Not in model		Not in model
SF-20 mental health	Not in model		Not in model		Not in model		Not in model
RSCL physical symptoms	0.668 (0.470–0.942)	0.021	Not in model		0.641 (0.442–0.942)	0.024	Not in model
RSCL activity level	Not in model		0.785 (0.641–0.980)	0.037	Not in model		0.724 (0.975–0.992)	<0.001
RSCL psychological symptoms	Not in model		Not in model		Not in model		Not in model
RSCL global quality of life	Not in model		Not in model		Not in model		Not in model
Clinical
Age [years]	Not in model		Not in model		Not in model		Not in model
Sex (male/female)	Not in model		Not in model		Not in model		Not in model
Weight loss [kg]	Not in model		Not in model		Not in model		Not in model
Tumor length [cm]	1.082 (1.006–1.164)	0.034	Not in model		1.112 (1.029–1.198)	0.008	Not in model
uT-stage
T1 vs. T3	0.050 (0.007–0.361)	0.003	NA		0.029 (0.0002–0.207)	<0.001	NA
T2 vs. T3	0.912 (0.554–1.501)	0.717	NA		0.975 (0.585–1.558)	0.918	NA
uN-stage (N1 vs. N0)	Not in model		NA		Not in model		NA
pT-stage
T1 vs. T3	NA		0.122 (0.041–0.367)	<0.001	NA		0.124 (0.035–0.441)	0.001
T2 vs. T3	NA		0.430 (0.229–0.809)	0.009	NA		0.463 (0.232–0.922)	0.029
pN-stage (N1 vs. N0)	NA		3.433 (1.798–6.555)	<0.001	NA		3.385 (1.640–6.986)	0.001

HR hazard ratio, CI confidence interval, u ultrasonographical, p pathological, NA not applicable, SF-20 medical outcomes study short form, RSCL Rotterdam symptom checklist

aHazard ratio provides the likelihood of recurrent disease for a patient with a score of 20 points more than another patient

bHazard ratio provides the likelihood of recurrent disease for a patient with a score of 20 points more than another patient

All variables with a p-value < 0.05 were made bold

Univariate analysis of the postoperative QoL subscale scores revealed many significant predictors for overall survival: SF20 health perception (HR 0.835; p = 0.027), SF20 social functioning (HR 0.887; p = 0.011), SF20 energy (HR 0.785; p = 0.006), SF20 pain (HR 1.196; p = 0.006), SF20 mental health (HR 0.818; p = 0.030), RSCL physical symptoms (HR 0.724; p = 0.017), RSCL activity level (HR 0.710; p < 0.001), and RSCL global quality of life (HR 0.770; p = 0.004). Weight loss (HR 1.033; p = 0.019) and tumor length (HR 1.138; p < 0.001) were again clinical predictors for overall survival on univariate analysis. Pathological T-stage (T1 versus T3 HR 0.084; p < 0.001 and T2 versus T3 HR 0.487; p = 0.014) and pathological N-stage (HR 4.617; p < 0.001) were also significantly predictive for overall survival.

After backward elimination, the final multivariate Cox regression model for postoperative parameters showed SF20 social functioning (HR 0.835; p = 0.035), SF20 pain (HR 1.196; p = 0.026), RSCL activity level (HR 0.785; p = 0.037), pathological T-stage (T1 versus T3 HR 0.122; p < 0.001 and T2 versus T3 HR 0.430; p = 0.009), and pathological N-stage (HR 3.433; p < 0.001) as independent predictors for overall survival.

Preoperative univariate Cox regression analysis of risk factors for disease-free survival showed again that RSCL physical symptoms (HR 0.641; p = 0.012), RSCL activity level (HR 0.695; p = 0.038), weight loss (HR 1.044; p = 0.001), tumor length (HR 1.159; p < 0.001), and endosonographic T-stage (T1 versus T3 HR 0.020; p < 0.001 and T2 versus T3 HR 0.868; p = 0.540) were significant predictors (Table 3). After backward elimination only RSCL physical symptoms (HR 0.641; p = 0.024), tumor length (HR 1.112; p = 0.008), and endosonographic T-stage (T1 versus T3 HR 0.029; p < 0.001 and T2 versus T3 HR 0.975; p = 0.918) were significant predictors in the multivariate model for disease-free survival (Table 4).

Postoperative univariate Cox regression analysis for disease-free survival showed the same range of QoL subscales to be significantly predictive as in the univariate analysis for overall survival, except that SF-20 physical functioning was a significant predictor in the disease-free analysis and SF-20 social functioning was not (Table 3). After backward elimination a multivariate model was created including only significant predictors for disease-free survival: SF-20 pain (HR 1.321; p = 0.001), RSCL activity level (HR 0.724; p < 0.001), pathological T-stage (T1 versus T3 HR 0.124; 0 = 0.001 and T2 versus T3 HR 0.463; p = 0.029), and pathological N-stage (HR 3.385; p = 0.001).

Discussion

In the present paper the first large consecutive series of potentially curable esophageal cancer patients is presented in whom prospectively collected QoL data before and after potentially curative surgical resection were used to predict survival. In the preoperative setting only the physical symptom scale was an independent predictor of overall survival, besides the well-known tumor length and endosonographic T-stage.6,24 In the postoperative setting the social functioning scale, the pain scale, and the activity level predicted overall survival independently, besides pathological T-stage and N-stage. Analysis for disease-free survival in the postoperative setting showed the pain scale and activity level to be even stronger predictors compared with overall survival.

QoL subscales that were found to predict survival were different preoperatively (physical symptoms) compared with postoperatively (social functioning, pain, and activity level). It might be hypothesized that the predictive strength of preoperative QoL is dominated by the physical symptom subscale, because it probably reflects tumor stage. Perhaps, a more aggressive and extensive tumor would result in a lower score on this specific subscale and therefore in worse survival. Postoperative QoL subscales predicting survival seemed to be more related to the recovery from the immobilizing and painful effects of major surgery (social functioning, pain, and activity level). However, it remains unclear whether these surgery-related effects fully account for the prognostic significance of these specific subscales.

In addition to intrinsic differences in pre- and postoperative QoL measurements, clinical applicability would also be quite different. Preoperative QoL measurements have significant additional value in disclosing individual prognosis. Using our multivariate prediction model, it might even be possible to help patients making treatment-related decisions. By adding the predictive QoL subscales to conventional staging modalities, a more realistic prognosis can be disclosed, which ensures patients to make well-considered choices.

Postoperative predictive QoL subscales, in combination with pathological tumor stage, can help to reassess individual prognosis. Our data indicate that, in patients who explicitly want to be informed about their prognosis, longitudinal QoL measurements can be useful. The fact that the pain subscale and activity level are such strong predictors for disease-free survival suggests that in the future these measurements might even be used as surveillance modality for recurrent disease; a low score on these subscales could be an indication for further diagnostic imaging.

Few studies have investigated the prognostic value of pretreatment QoL in patients with esophageal cancer.14–16 Data from the three available studies support the view that a lower pretreatment score on some of the QoL subscales negatively affects survival, but all three studies consisted of heterogeneous patient populations with both potentially curable and incurable patients. Predictive value of posttreatment QoL subscales has not previously been investigated at all for this group of patients. One study examined the change between baseline QoL subscales and posttreatment QoL subscales, albeit in a relatively small series of patients (n = 38).14

The first study by Blazeby et al. investigating prognostic value of QoL for patients with esophageal cancer included 89 patients with disease stage II–IV and used European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and EORTC OES24 QoL questionnaires.14 Potentially curative esophagectomy was performed in 55 of the patients; no subgroup analysis was performed using only these patients. The authors found that better pretreatment physical function was associated with longer survival. This corresponds with our results indicating preoperative physical symptoms to be predictive for survival. In that same study the change in emotional function between baseline QoL and the measurement 6 months after treatment was also reported to be significantly predictive for survival, even in a relatively small subgroup of patients (n = 38). Corresponding postoperative QoL subscales in the present study (e.g., mental and/or psychological function) did not prove to be independently predictive for survival.

In a study by Chau et al., including over 1,000 mainly metastatic esophageal cancer patients the EORTC QLQ-C30 questionnaire was used to assess the prognostic value of pretreatment QoL.15 Physical function, role function, and global quality of life were found to be independent predictors for survival. Unfortunately, the QoL subscales were only analyzed separately in different multivariate models, each including several clinical factors and one QoL subscale, therefore the possible interrelationship between the QoL subscales remains unclear.

A recently published paper investigating QoL as a predictor for survival, also using the EORTC QLQ-C30, found only preoperative appetite loss to be an independent prognostic factor in patients with gastroesophageal cancer.16 Appetite loss is one of the 23 items of which our RSCL physical function subscale is composed. We deliberately chose not to analyze all QoL items separately and only to use subscales, to reduce chance-related findings.

In the present study, a fairly homogeneous patient population of potentially curable patients with esophageal cancer was used. This is in contrast to previous studies consisting of rather heterogeneous patient populations also including locally advanced (T4) and metastatic (M1) tumors.14–16 Heterogeneity leads to less precise results for individual prognosis. The restrictive selection criteria that were applied in our study, however, limit its generalizability. Another potential limitation of the present study is that we did not assess the more recently discovered (pathological) predictors, such as extracapsular lymph node involvement.25 Furthermore, it is generally accepted to include approximately one variable in multivariate logistic regression analysis for every ten events in the patient population. Therefore, the total number of variables that can be tested is limited. Nevertheless, we did assess the influence of the main comparison of the original randomized trial: although some QoL variables differed significantly 3 months after surgery between the transhiatal and the transthoracic group, including surgical approach as a variable in the multivariate analysis did not influence the prognostic significance of QoL and other variables.22

Remarkably, endosonographic N-stage was not a significant predictor for survival in our study, not even on univariate analysis. This is in contrast with previous reports.24,26

Most studies investigating preoperative prognostication using QoL also include pathological TNM stage in the multivariate Cox regression models.14–16 Since pathological stage is not available preoperatively, we used a more realistic approach, including only clinical factors actually available preoperatively.

In conclusion, the results of the present study support the application of predictive QoL subscales in daily clinical practice before and after surgery.

Current guidelines on diagnosis and treatment of esophageal cancer do not recommend any form of postoperative monitoring, while patient preference for disclosure of an individual prognosis is still prominent postoperatively.8 Therefore, postoperative predictive QoL subscales combined with pathological TNM stage could be a useful, noninvasive approach to update and improve individual prognosis.