BACKGROUND: Minimally invasive esophagectomy may improve some perioperative outcomes over open approaches; effects on quality of life are less clear. METHODS: A prospective trial of robotic-assisted minimally invasive esophagectomy (RAMIE) and open esophagectomy was initiated, measuring quality of life via the Functional Assessment of Cancer Therapy-Esophageal and Brief Pain Inventory. Mixed generalized linear models assessed associations between quality of life scores over time and by surgery type. RESULTS: In total, 106 patients underwent open esophagectomy; 64 underwent minimally invasive esophagectomy (98% RAMIE). The groups did not differ in age, sex, comorbidities, histologic subtype, stage, or induction treatment (P = .42 to P > .95). Total Functional Assessment of Cancer Therapy-Esophageal scores were lower at 1 month (P < .001), returned to near baseline by 4 months, and did not differ between groups (P = .83). Brief Pain Inventory average pain severity (P = .007) and interference (P = .004) were lower for RAMIE. RAMIE had lower estimated blood loss (250 vs 350 cm3; P < .001), shorter length of stay (9 vs 11 days; P < .001), fewer intensive care unit admissions (8% vs 20%; P = .033), more lymph nodes harvested (25 vs 22; P = .05), and longer surgical time (6.4 vs 5.4 hours; P < .001). Major complications (39% for RAMIE vs 52% for open esophagectomy; P > .95), anastomotic leak (3% vs 9%; P = .41), and 90-day mortality (2% vs 4%; P = .85) did not differ between groups. Pulmonary (14% vs 34%; P = .014) and infectious (17% vs 36%; P = .029) complications were lower for RAMIE. CONCLUSIONS: RAMIE is associated with lower immediate postoperative pain severity and interference and decreased pulmonary and infectious complications. Ongoing data accrual will assess mid-term and long-term outcomes in this cohort.
BACKGROUND: Minimally invasive esophagectomy may improve some perioperative outcomes over open approaches; effects on quality of life are less clear. METHODS: A prospective trial of robotic-assisted minimally invasive esophagectomy (RAMIE) and open esophagectomy was initiated, measuring quality of life via the Functional Assessment of Cancer Therapy-Esophageal and Brief Pain Inventory. Mixed generalized linear models assessed associations between quality of life scores over time and by surgery type. RESULTS: In total, 106 patients underwent open esophagectomy; 64 underwent minimally invasive esophagectomy (98% RAMIE). The groups did not differ in age, sex, comorbidities, histologic subtype, stage, or induction treatment (P = .42 to P > .95). Total Functional Assessment of Cancer Therapy-Esophageal scores were lower at 1 month (P < .001), returned to near baseline by 4 months, and did not differ between groups (P = .83). Brief Pain Inventory average pain severity (P = .007) and interference (P = .004) were lower for RAMIE. RAMIE had lower estimated blood loss (250 vs 350 cm3; P < .001), shorter length of stay (9 vs 11 days; P < .001), fewer intensive care unit admissions (8% vs 20%; P = .033), more lymph nodes harvested (25 vs 22; P = .05), and longer surgical time (6.4 vs 5.4 hours; P < .001). Major complications (39% for RAMIE vs 52% for open esophagectomy; P > .95), anastomotic leak (3% vs 9%; P = .41), and 90-day mortality (2% vs 4%; P = .85) did not differ between groups. Pulmonary (14% vs 34%; P = .014) and infectious (17% vs 36%; P = .029) complications were lower for RAMIE. CONCLUSIONS:RAMIE is associated with lower immediate postoperative pain severity and interference and decreased pulmonary and infectious complications. Ongoing data accrual will assess mid-term and long-term outcomes in this cohort.
Authors: Robert H Dworkin; Dennis C Turk; John T Farrar; Jennifer A Haythornthwaite; Mark P Jensen; Nathaniel P Katz; Robert D Kerns; Gerold Stucki; Robert R Allen; Nicholas Bellamy; Daniel B Carr; Julie Chandler; Penney Cowan; Raymond Dionne; Bradley S Galer; Sharon Hertz; Alejandro R Jadad; Lynn D Kramer; Donald C Manning; Susan Martin; Cynthia G McCormick; Michael P McDermott; Patrick McGrath; Steve Quessy; Bob A Rappaport; Wendye Robbins; James P Robinson; Margaret Rothman; Mike A Royal; Lee Simon; Joseph W Stauffer; Wendy Stein; Jane Tollett; Joachim Wernicke; James Witter Journal: Pain Date: 2005-01 Impact factor: 6.961
Authors: Haris Zahoor; James D Luketich; Ryan M Levy; Omar Awais; Daniel G Winger; Michael K Gibson; Katie S Nason Journal: J Thorac Cardiovasc Surg Date: 2014-10-14 Impact factor: 5.209
Authors: Sebastian G de la Fuente; Jill Weber; Sarah E Hoffe; Ravi Shridhar; Richard Karl; Kenneth L Meredith Journal: Surg Endosc Date: 2013-04-03 Impact factor: 4.584
Authors: Surya S A Y Biere; Mark I van Berge Henegouwen; Kirsten W Maas; Luigi Bonavina; Camiel Rosman; Josep Roig Garcia; Suzanne S Gisbertz; Jean H G Klinkenbijl; Markus W Hollmann; Elly S M de Lange; H Jaap Bonjer; Donald L van der Peet; Miguel A Cuesta Journal: Lancet Date: 2012-05-01 Impact factor: 79.321
Authors: R Parameswaran; A McNair; K N L Avery; R G Berrisford; S A Wajed; M A G Sprangers; J M Blazeby Journal: Ann Surg Oncol Date: 2008-07-15 Impact factor: 5.344
Authors: Inderpal S Sarkaria; Nabil P Rizk; David J Finley; Manjit S Bains; Prasad S Adusumilli; James Huang; Valerie W Rusch Journal: Eur J Cardiothorac Surg Date: 2013-01-30 Impact factor: 4.191
Authors: Mark van Heijl; Mirjam A G Sprangers; Angela G E M de Boer; Sjoerd M Lagarde; Hans B Reitsma; Olivier R C Busch; Hugo W Tilanus; Jan J B van Lanschot; Mark I van Berge Henegouwen Journal: Ann Surg Oncol Date: 2009-10-15 Impact factor: 5.344
Authors: Gijsbert I van Boxel; B Feike Kingma; Frank J Voskens; Jelle P Ruurda; Richard van Hillegersberg Journal: J Thorac Dis Date: 2020-02 Impact factor: 2.895
Authors: Xi Luo; Qin Xie; Qiuling Shi; Yan Miao; Qingsong Yu; Hongfan Yu; Hong Yin; Xuefeng Leng; Yongtao Han; Hong Zhou Journal: Support Care Cancer Date: 2021-11-24 Impact factor: 3.603
Authors: Stepan M Esagian; Ioannis A Ziogas; Konstantinos Skarentzos; Ioannis Katsaros; Georgios Tsoulfas; Daniela Molena; Michalis V Karamouzis; Ioannis Rouvelas; Magnus Nilsson; Dimitrios Schizas Journal: Cancers (Basel) Date: 2022-06-29 Impact factor: 6.575
Authors: Jan-Hendrik Egberts; Thilo Welsch; Felix Merboth; Sandra Korn; Christian Praetorius; Daniel E Stange; Marius Distler; Matthias Biebl; Johann Pratschke; Felix Nickel; Beat Müller-Stich; Daniel Perez; Jakob R Izbicki; Thomas Becker; Jürgen Weitz Journal: Langenbecks Arch Surg Date: 2022-05-02 Impact factor: 2.895
Authors: Marc Vimolratana; Inderpal S Sarkaria; Debra A Goldman; Nabil P Rizk; Kay See Tan; Manjit S Bains; Prasad S Adusumilli; Smita Sihag; James M Isbell; James Huang; Bernard J Park; Daniela Molena; Valerie W Rusch; David R Jones; Matthew J Bott Journal: Ann Thorac Surg Date: 2020-11-04 Impact factor: 5.102