Literature DB >> 19784622

Patients' characterization, hospital course and clinical outcomes in five Italian respiratory intensive care units.

Eva Polverino1, Stefano Nava, Miquel Ferrer, Piero Ceriana, Enrico Clini, Elisa Spada, Ercole Zanotti, Ludovico Trianni, Luca Barbano, Claudio Fracchia, Bruno Balbi, Michele Vitacca.   

Abstract

BACKGROUND: Respiratory intensive care units (RICU) dedicated to weaning could be suitable facilities for clinical management of "post-ICU" patients.
METHODS: We retrospectively analyzed the time course of patients' characteristics, clinical outcomes and medical staff utilization in five Italian RICUs by comparing three periods of 5 consecutive years (from 1991 to 2005).
RESULTS: A total of 3,106 patients (age 76 +/- 4 years; 72% males) were analyzed. The number of co-morbidities per patient (from 1.8 to 3.0, p = 0.05) and the previous intensive care unit (ICU) stay (from 25 to 32 days, p = 0.002) increased over time. The doctor-to-patient ratio significantly decreased over time (from 1:3 to 1:5, p < 0.01), whereas the physiotherapist-to-patient ratio mildly increased (from 1:6 to 1:4.5, p < 0.05). The overall weaning success rate decreased (from 87 to 66%, p < 0.001), and the discharge destination changed (p < 0.001) over time; fewer patients were discharged to home (from 22 to 10%), and more patients to nursing home (from 3 to 6%), acute hospitals (from 6 to 10%) and rehabilitative units (from 70 to 75%). The mortality rate increased over time (from 9 to 15%). Significant correlations between the doctor-to-patient ratio and the rates of weaning success (r = 0.679, p = 0.005), home discharge (r = 0.722, p = 0.002) and the RICU length of stay (LOS) (r = -0.683, p = 0.005) were observed.
CONCLUSIONS: The clinical outcomes of our units worsened over 15 years, likely as consequence of admitting more severely ill patients. The potential further negative influence of reduced medical staff availability on weaning success, home discharge and LOS warrants future prospective investigations.

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Year:  2009        PMID: 19784622     DOI: 10.1007/s00134-009-1658-2

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN: 0342-4642            Impact factor:   17.440


  24 in total

Review 1.  International Consensus Conferences in Intensive Care Medicine: noninvasive positive pressure ventilation in acute Respiratory failure.

Authors: 
Journal:  Am J Respir Crit Care Med       Date:  2001-01       Impact factor: 21.405

2.  Post-ICU mechanical ventilation: treatment of 1,123 patients at a regional weaning center.

Authors:  D J Scheinhorn; D C Chao; M Stearn-Hassenpflug; L D LaBree; D J Heltsley
Journal:  Chest       Date:  1997-06       Impact factor: 9.410

3.  A community-based regional ventilator weaning unit: development and outcomes.

Authors:  P H Bagley; E Cooney
Journal:  Chest       Date:  1997-04       Impact factor: 9.410

4.  Comparison of two methods for weaning patients with chronic obstructive pulmonary disease requiring mechanical ventilation for more than 15 days.

Authors:  M Vitacca; A Vianello; D Colombo; E Clini; R Porta; L Bianchi; G Arcaro; G Vitale; E Guffanti; A Lo Coco; N Ambrosino
Journal:  Am J Respir Crit Care Med       Date:  2001-07-15       Impact factor: 21.405

5.  Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)

Authors:  A F Connors; N V Dawson; C Thomas; F E Harrell; N Desbiens; W J Fulkerson; P Kussin; P Bellamy; L Goldman; W A Knaus
Journal:  Am J Respir Crit Care Med       Date:  1996-10       Impact factor: 21.405

6.  Modes of mechanical ventilation and weaning. A national survey of Spanish hospitals. The Spanish Lung Failure Collaborative Group.

Authors:  A Esteban; I Alía; J Ibañez; S Benito; M J Tobin
Journal:  Chest       Date:  1994-10       Impact factor: 9.410

7.  Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously.

Authors:  E W Ely; A M Baker; D P Dunagan; H L Burke; A C Smith; P T Kelly; M M Johnson; R W Browder; D L Bowton; E F Haponik
Journal:  N Engl J Med       Date:  1996-12-19       Impact factor: 91.245

8.  Weaning from mechanical ventilation.

Authors:  J-M Boles; J Bion; A Connors; M Herridge; B Marsh; C Melot; R Pearl; H Silverman; M Stanchina; A Vieillard-Baron; T Welte
Journal:  Eur Respir J       Date:  2007-05       Impact factor: 16.671

9.  Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease.

Authors:  M G Seneff; D P Wagner; R P Wagner; J E Zimmerman; W A Knaus
Journal:  JAMA       Date:  1995-12-20       Impact factor: 56.272

10.  Life expectancy of ventilator-dependent persons with spinal cord injuries.

Authors:  M J DeVivo; C S Ivie
Journal:  Chest       Date:  1995-07       Impact factor: 9.410

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  15 in total

Review 1.  Managing the apparent and hidden difficulties of weaning from mechanical ventilation.

Authors:  Andreas Perren; Laurent Brochard
Journal:  Intensive Care Med       Date:  2013-07-18       Impact factor: 17.440

2.  The evolving role of dedicated weaning facilities in critical care.

Authors:  Jeremy M Kahn
Journal:  Intensive Care Med       Date:  2009-09-26       Impact factor: 17.440

3.  Characteristics and outcome of patients with difficult weaning from mechanical ventilation: an 18 years' experience of a respiratory intermediate unit attached to a pulmonary department.

Authors:  V Tsara; N Moisiadis; M Antoniadou; E Serasli
Journal:  Hippokratia       Date:  2015 Jan-Mar       Impact factor: 0.471

4.  Assessment of Sleep in Patients Receiving Invasive Mechanical Ventilation in a Specialized Weaning Unit.

Authors:  Sophie Emilia Huttmann; Katharina Wilms; Christine Hamm; Friederike Sophie Magnet; Wolfram Windisch; Jan Hendrik Storre
Journal:  Lung       Date:  2017-03-03       Impact factor: 2.584

5.  Year in review in Intensive Care Medicine 2010: II. Pneumonia and infections, cardiovascular and haemodynamics, organization, education, haematology, nutrition, ethics and miscellanea.

Authors:  Massimo Antonelli; Elie Azoulay; Marc Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel De Backer; Herwig Gerlach; Goran Hedenstierna; Michael Joannidis; Duncan Macrae; Jordi Mancebo; Salvatore M Maggiore; Alexandre Mebazaa; Jean-Charles Preiser; Jerôme Pugin; Jan Wernerman; Haibo Zhang
Journal:  Intensive Care Med       Date:  2011-01-12       Impact factor: 17.440

6.  Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial.

Authors:  Amal Jubran; Brydon J B Grant; Lisa A Duffner; Eileen G Collins; Dorothy M Lanuza; Leslie A Hoffman; Martin J Tobin
Journal:  JAMA       Date:  2013-02-20       Impact factor: 56.272

7.  Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis.

Authors:  Bronagh Blackwood; Fiona Alderdice; Karen Burns; Chris Cardwell; Gavin Lavery; Peter O'Halloran
Journal:  BMJ       Date:  2011-01-13

8.  Long-Term Outcome after Prolonged Mechanical Ventilation. A Long-Term Acute-Care Hospital Study.

Authors:  Amal Jubran; Brydon J B Grant; Lisa A Duffner; Eileen G Collins; Dorothy M Lanuza; Leslie A Hoffman; Martin J Tobin
Journal:  Am J Respir Crit Care Med       Date:  2019-06-15       Impact factor: 30.528

Review 9.  The patient needing prolonged mechanical ventilation: a narrative review.

Authors:  Nicolino Ambrosino; Michele Vitacca
Journal:  Multidiscip Respir Med       Date:  2018-02-26

10.  Quality of life and life satisfaction are severely impaired in patients with long-term invasive ventilation following ICU treatment and unsuccessful weaning.

Authors:  Sophie Emilia Huttmann; Friederike Sophie Magnet; Christian Karagiannidis; Jan Hendrik Storre; Wolfram Windisch
Journal:  Ann Intensive Care       Date:  2018-03-16       Impact factor: 6.925

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