Literature DB >> 19776555

Views on personalized medicine: do the attitudes of African American and white prescription drug consumers differ?

M De Marco1, S Cykert, N Coad, K Doost, J Schaal, B White, D Young, M R Isler, G Corbie-Smith.   

Abstract

AIMS: Although recent advances in pharmacogenomics are making possible the use of genetic testing to determine the best medication for patients, little is known about how patients view such procedures. The aims for this study that were developed collaboratively as part of a community-academic partnership are: (1) What are the attitudes and perceptions of prescription drug consumers concerning personalized medicine and genetic testing for drug compatibility and how do they differ between African American and white patients? (2) What are the attitudes and perceptions of patients concerning race-based prescribing and how do they differ between African American and white patients?
METHODS: We conducted 6 focus groups, 2 with white participants and 4 with African American participants. Focus groups were audio-recorded, transcribed, and analyzed to ascertain common themes.
RESULTS: Our results suggest that personalized medicine and genetic testing, though not well understood by lay persons, were considered positive advances in medicine. However, participants also voiced concerns about these advances that differed by race.
CONCLUSION: This study points to the need to include perspectives of at-risk communities as we move toward wider use of this technology.

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Year:  2009        PMID: 19776555      PMCID: PMC2914357          DOI: 10.1159/000242199

Source DB:  PubMed          Journal:  Public Health Genomics        ISSN: 1662-4246            Impact factor:   2.000


  14 in total

1.  Informed lay preferences for delivery of racially varied pharmacogenomics.

Authors:  Jennifer L Bevan; Jonh A Lynch; Tasha N Dubriwny; Tina M Harris; Paul J Achter; Amy L Reeder; Celeste M Condit
Journal:  Genet Med       Date:  2003 Sep-Oct       Impact factor: 8.822

2.  Attitudes about genetics in underserved, culturally diverse populations.

Authors:  Diana S Catz; Nancy S Green; Jonathan N Tobin; Michele A Lloyd-Puryear; Penny Kyler; Ann Umemoto; Jennifer Cernoch; Roxane Brown; Fredericka Wolman
Journal:  Community Genet       Date:  2005

Review 3.  Foundations, promises and uncertainties of personalized medicine.

Authors:  Erwin P Bottinger
Journal:  Mt Sinai J Med       Date:  2007-04

4.  The continuing legacy of the Tuskegee Syphilis Study: considerations for clinical investigation.

Authors:  G Corbie-Smith
Journal:  Am J Med Sci       Date:  1999-01       Impact factor: 2.378

Review 5.  Under the shadow of Tuskegee: African Americans and health care.

Authors:  V N Gamble
Journal:  Am J Public Health       Date:  1997-11       Impact factor: 9.308

6.  A lay prescription for tailor-made drugs--focus group reflections on pharmacogenomics.

Authors:  Anna Birna Almarsdóttir; Ingunn Björnsdóttir; Janine Morgall Traulsen
Journal:  Health Policy       Date:  2005-02       Impact factor: 2.980

7.  Tailored medicine: whom will it fit? The ethics of patient and disease stratification.

Authors:  Andrew Smart; Paul Martin; Michael Parker
Journal:  Bioethics       Date:  2004-08       Impact factor: 1.898

8.  The Tuskegee Syphilis Study, 1932 to 1972: implications for HIV education and AIDS risk education programs in the black community.

Authors:  S B Thomas; S C Quinn
Journal:  Am J Public Health       Date:  1991-11       Impact factor: 9.308

9.  Exploration of the impact of messages about genes and race on lay attitudes.

Authors:  C M Condit; R L Parrott; B R Bates; J Bevan; P J Achter
Journal:  Clin Genet       Date:  2004-11       Impact factor: 4.438

10.  The African-American Heart Failure Trial: background, rationale and significance.

Authors:  Anne L Taylor; Jay N Cohn; Manuel Worcel; Joseph A Franciosa
Journal:  J Natl Med Assoc       Date:  2002-09       Impact factor: 1.798

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  11 in total

1.  Assessment of patient perceptions of genomic testing to inform pharmacogenomic implementation.

Authors:  Yee Ming Lee; Ryan P McKillip; Brittany A Borden; Catherine E Klammer; Mark J Ratain; Peter H O'Donnell
Journal:  Pharmacogenet Genomics       Date:  2017-05       Impact factor: 2.089

2.  Opinions, hopes and concerns regarding pharmacogenomics: a comparison of healthy individuals, heart failure patients and heart transplant recipients.

Authors:  K Lachance; S Korol; E O'Meara; A Ducharme; N Racine; M Liszkowski; J L Rouleau; G B Pelletier; M Carrier; M White; S de Denus
Journal:  Pharmacogenomics J       Date:  2014-07-01       Impact factor: 3.550

3.  Attitudes toward pharmacogenetics in patients undergoing CYP2C19 testing following percutaneous coronary intervention.

Authors:  Grace Lee; Lisa A Varughese; Laura Conway; Carol Stojinski; Sandhya Ashokkumar; Karen Monono; William Matthai; Daniel M Kolansky; Jay Giri; Sony Tuteja
Journal:  Per Med       Date:  2022-01-05       Impact factor: 2.512

4.  Pharmacogenomics in Children.

Authors:  Michael J Rieder; Abdelbaset A Elzagallaai
Journal:  Methods Mol Biol       Date:  2022

5.  Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis.

Authors:  Sadaf Qureshi; Asam Latif; Laura Condon; Ralph K Akyea; Joe Kai; Nadeem Qureshi
Journal:  Pharmacogenomics       Date:  2021-12-16       Impact factor: 2.638

6.  BiDil in the Clinic: An Interdisciplinary Investigation of Physicians' Prescription Patterns of a Race-Based Therapy.

Authors:  Koffi N Maglo; Jack Rubinstein; Bin Huang; Richard F Ittenbach
Journal:  AJOB Empir Bioeth       Date:  2014-10-02

7.  Patient reactions to personalized medicine vignettes: an experimental design.

Authors:  Morgan Butrick; Debra Roter; Kimberly Kaphingst; Lori H Erby; Carlton Haywood; Mary Catherine Beach; Howard P Levy
Journal:  Genet Med       Date:  2011-05       Impact factor: 8.822

8.  African Americans' responses to genetic explanations of lung cancer disparities and their willingness to participate in clinical genetics research.

Authors:  Della Brown White; Laura M Koehly; Adedamola Omogbehin; Colleen M McBride
Journal:  Genet Med       Date:  2010-08       Impact factor: 8.822

9.  An empirical estimate of carrier frequencies for 400+ causal Mendelian variants: results from an ethnically diverse clinical sample of 23,453 individuals.

Authors:  Gabriel A Lazarin; Imran S Haque; Shivani Nazareth; Kevin Iori; A Scott Patterson; Jessica L Jacobson; John R Marshall; William K Seltzer; Pasquale Patrizio; Eric A Evans; Balaji S Srinivasan
Journal:  Genet Med       Date:  2012-09-13       Impact factor: 8.822

10.  Efficacy and safety of liraglutide, a once-daily human glucagon-like peptide-1 receptor agonist, in African-American people with Type 2 diabetes: a meta-analysis of sub-population data from seven phase III trials.

Authors:  M E Shomali; D D Ørsted; A J Cannon
Journal:  Diabet Med       Date:  2016-08-16       Impact factor: 4.359

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