| Literature DB >> 19719093 |
Shugeng Cao1, Peggy Brodie, Martin Callmander, Richard Randrianaivo, Jeremi Razafitsalama, Etienne Rakotobe, Vincent E Rasamison, Karen TenDyke, Yongchun Shen, Edward M Suh, David G I Kingston.
Abstract
Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC(50) values of 0.79 and 0.70 muM, respectively.Entities:
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Year: 2009 PMID： 19719093 PMCID： PMC2930020 DOI： 10.1021/np900293x
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050