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Literature DB >> 17263578

Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.

Shugeng Cao¹, Andrew Norris, James S Miller, Fidy Ratovoson, Jeremi Razafitsalama, Rabodo Andriantsiferana, Vincent E Rasamison, Karen TenDyke, Ted Suh, David G I Kingston.

Abstract

Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C (1-3). The structures of these new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1-3 showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.

Entities: Chemical Disease Species

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Year: 2007 PMID： 17263578 PMCID： PMC2442826 DOI： 10.1021/np060506g

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

24 in total

1. Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.

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Journal: Bioorg Med Chem Date: 1997-08 Impact factor: 3.641

2. Saponins from Polygala japonica and their effects on a forced swimming test in mice.

Authors: Ting-Zhao Li; Wei-Dong Zhang; Gen-Jin Yang; Wen-Yong Liu; Hai-Sheng Chen; Yun-Heng Shen
Journal: J Nat Prod Date: 2006-04 Impact factor: 4.050

3. Cytotoxic glycosides from Albizia julibrissin.

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Journal: J Nat Prod Date: 1997-02 Impact factor: 4.050

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Authors: Shugeng Cao; Rebecca C Guza; Jan H Wisse; James S Miller; Randy Evans; David G I Kingston
Journal: J Nat Prod Date: 2005-04 Impact factor: 4.050

5. New macrocyclic spermine (budmunchiamine) alkaloids from Albizia gummifera: with some observations on the structure--activity relationships of the budmunchiamines.

Authors: G M Rukunga; P G Waterman
Journal: J Nat Prod Date: 1996-09 Impact factor: 4.050

6. Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

Authors: Russell B Williams; Andrew Norris; James S Miller; Chris Birkinshaw; Fidy Ratovoson; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal: J Nat Prod Date: 2007-02 Impact factor: 4.050

7. Induction of apoptosis in a leukemia cell line by triterpene saponins from Albizia adianthifolia.

Authors: Mohamed Haddad; Véronique Laurens; Marie-Aleth Lacaille-Dubois
Journal: Bioorg Med Chem Date: 2004-09-01 Impact factor: 3.641

8. Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

Authors: K G Louie; B C Behrens; T J Kinsella; T C Hamilton; K R Grotzinger; W M McKoy; M A Winker; R F Ozols
Journal: Cancer Res Date: 1985-05 Impact factor: 12.701

9. Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae.

Authors: Gamini S Jayatilake; Delano R Freeberg; Zhengjie Liu; Steve L Richheimer; Mary E Blake Nieto; David T Bailey; Valsala Haridas; Jordan U Gutterman
Journal: J Nat Prod Date: 2003-06 Impact factor: 4.050

10. Dammarane-type glycosides from Gynostemma pentaphyllum.

Authors: Feng Yin; Lihong Hu; Fengchang Lou; Ruixiang Pan
Journal: J Nat Prod Date: 2004-06 Impact factor: 4.050

15 in total

1. Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).

Authors: Shugeng Cao; Peggy J Brodie; James S Miller; Fidy Ratovoson; Martin W Callmander; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; Edward M Suh; Karen TenDyke; David G I Kingston
Journal: J Nat Prod Date: 2007-06-05 Impact factor: 4.050

2. Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest.

Authors: Shugeng Cao; Peggy J Brodie; Martin Callmander; Richard Randrianaivo; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal: Phytochemistry Date: 2009-10-28 Impact factor: 4.072

3. Cytotoxic oleanane-type saponins from Albizia inundata.

Authors: Huaping Zhang; Abbas K Samadi; Karumanchi V Rao; Mark S Cohen; Barbara N Timmermann
Journal: J Nat Prod Date: 2011-02-11 Impact factor: 4.050

4. Molecular mechanisms of Bombyx batryticatus ethanol extract inducing gastric cancer SGC-7901 cells apoptosis.

Authors: Jin-Yi Wu; Almutamad Sheikho; He Ma; Tian-Ci Li; Ya-Qi Zhao; Ya-Lin Zhang; Dun Wang
Journal: Cytotechnology Date: 2017-05-24 Impact factor: 2.058

5. Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

Authors: Brent J Yoder; Shugeng Cao; Andrew Norris; James S Miller; Fidy Ratovoson; Jeremi Razafitsalama; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal: J Nat Prod Date: 2007-02-28 Impact factor: 4.050

6. Saponins as cytotoxic agents: a review.

Authors: Irma Podolak; Agnieszka Galanty; Danuta Sobolewska
Journal: Phytochem Rev Date: 2010-06-25 Impact factor: 5.374

7. Antiproliferative triterpenoid saponins of Dodonaea viscosa from the Madagascar dry forest.

Authors: Shugeng Cao; Peggy Brodie; Martin Callmander; Richard Randrianaivo; Jeremi Razafitsalama; Etienne Rakotobe; Vincent E Rasamison; Karen TenDyke; Yongchun Shen; Edward M Suh; David G I Kingston
Journal: J Nat Prod Date: 2009-09 Impact factor: 4.050