| Literature DB >> 34094656 |
Chella Perumal Palanisamy1, Bo Cui1, Hongxia Zhang1, Mani Panagal2, Sivagurunathan Paramasivam3, Uma Chinnaiyan3, Selvaraj Jeyaraman4, Karthigeyan Murugesan5, Mauricio Rostagno6, Vijayakumar Sekar7, Srinivasa Prabhu Natarajan8.
Abstract
Ovarian cancer (OC) accounts for the highest tumor-related mortality among the gynecologic malignancies. Most of the OC patients diagnosed with advanced-stage (III and IV) this situation creates panic and provokes an emergency to discover a new therapeutic strategy. Plants that possess medicinal properties are gaining attention as they are enriched with various chemical compounds that are potential to treat various diseases. It is a prolonged process to provide innovative and significant leads against a range of pharmacological targets for a human disease management system. Though challenges and difficulties are faced in the development of a new drug, the emergence of combinatorial chemistry is providing a new ray of hope and also, the executed effort in discovering the drug, and a chemical compound has been remarkably successful. This review discussed the role of medicinal plants that are native of South Africa in treating the Ovarian Cancer and in drug discovery. AJCREntities:
Keywords: Ovarian cancer; anti-ovarian cancer activity; drug development; south african medicinal plants
Year: 2021 PMID: 34094656 PMCID: PMC8167668
Source DB: PubMed Journal: Am J Cancer Res ISSN: 2156-6976 Impact factor: 6.166