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Literature DB >> 19571877

Elite and stochastic models for induced pluripotent stem cell generation.

Abstract

Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.

Mesh：

Year: 2009 PMID： 19571877 DOI： 10.1038/nature08180

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

39 in total

1. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Authors: Nimet Maherali; Rupa Sridharan; Wei Xie; Jochen Utikal; Sarah Eminli; Katrin Arnold; Matthias Stadtfeld; Robin Yachechko; Jason Tchieu; Rudolf Jaenisch; Kathrin Plath; Konrad Hochedlinger
Journal: Cell Stem Cell Date: 2007-06-07 Impact factor: 24.633

2. Isolation of multipotent adult stem cells from the dermis of mammalian skin.

Authors: J G Toma; M Akhavan; K J Fernandes; F Barnabé-Heider; A Sadikot; D R Kaplan; F D Miller
Journal: Nat Cell Biol Date: 2001-09 Impact factor: 28.824

3. Induced pluripotent stem cells generated without viral integration.

Authors: Matthias Stadtfeld; Masaki Nagaya; Jochen Utikal; Gordon Weir; Konrad Hochedlinger
Journal: Science Date: 2008-09-25 Impact factor: 47.728

4. Reprogramming of human somatic cells to pluripotency with defined factors.

Authors: In-Hyun Park; Rui Zhao; Jason A West; Akiko Yabuuchi; Hongguang Huo; Tan A Ince; Paul H Lerou; M William Lensch; George Q Daley
Journal: Nature Date: 2007-12-23 Impact factor: 49.962

5. A high-efficiency system for the generation and study of human induced pluripotent stem cells.

Authors: Nimet Maherali; Tim Ahfeldt; Alessandra Rigamonti; Jochen Utikal; Chad Cowan; Konrad Hochedlinger
Journal: Cell Stem Cell Date: 2008-09-11 Impact factor: 24.633

6. Generation of germline-competent induced pluripotent stem cells.

Authors: Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal: Nature Date: 2007-06-06 Impact factor: 49.962

7. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Authors: Marius Wernig; Alexander Meissner; Ruth Foreman; Tobias Brambrink; Manching Ku; Konrad Hochedlinger; Bradley E Bernstein; Rudolf Jaenisch
Journal: Nature Date: 2007-06-06 Impact factor: 49.962

8. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

Authors: Masato Nakagawa; Michiyo Koyanagi; Koji Tanabe; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Keisuke Okita; Yuji Mochiduki; Nanako Takizawa; Shinya Yamanaka
Journal: Nat Biotechnol Date: 2007-11-30 Impact factor: 54.908

9. Reprogramming of pancreatic beta cells into induced pluripotent stem cells.

Authors: Matthias Stadtfeld; Kristen Brennand; Konrad Hochedlinger
Journal: Curr Biol Date: 2008-05-22 Impact factor: 10.834

10. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

Authors: Danwei Huangfu; René Maehr; Wenjun Guo; Astrid Eijkelenboom; Melinda Snitow; Alice E Chen; Douglas A Melton
Journal: Nat Biotechnol Date: 2008-06-22 Impact factor: 54.908

206 in total

Review 1. Nuclear reprogramming to a pluripotent state by three approaches.

Authors: Shinya Yamanaka; Helen M Blau
Journal: Nature Date: 2010-06-10 Impact factor: 49.962

2. myc maintains embryonic stem cell pluripotency and self-renewal.

Authors: Natalia V Varlakhanova; Rebecca F Cotterman; Wilhelmine N deVries; Judy Morgan; Leah Rae Donahue; Stephen Murray; Barbara B Knowles; Paul S Knoepfler
Journal: Differentiation Date: 2010-05-27 Impact factor: 3.880

3. Induced Pluripotent Stem Cells-A New Foundation in Medicine.

Authors: George T-J Huang
Journal: J Exp Clin Med Date: 2010-10-22

Review 4. Epigenetic landscape of pluripotent stem cells.

Authors: Ji Woong Han; Young-sup Yoon
Journal: Antioxid Redox Signal Date: 2012-01-11 Impact factor: 8.401

5. Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling.

Authors: Ryoji Sekine; Masayuki Yamamura; Shotaro Ayukawa; Kana Ishimatsu; Satoru Akama; Masahiro Takinoue; Masami Hagiya; Daisuke Kiga
Journal: Proc Natl Acad Sci U S A Date: 2011-10-24 Impact factor: 11.205

Review 6. Cellular genomics for complex traits.

Authors: Emmanouil T Dermitzakis
Journal: Nat Rev Genet Date: 2012-02-14 Impact factor: 53.242

Review 7. Measurement of single-cell dynamics.

Authors: David G Spiller; Christopher D Wood; David A Rand; Michael R H White
Journal: Nature Date: 2010-06-10 Impact factor: 49.962