Literature DB >> 22330769

Cellular genomics for complex traits.

Emmanouil T Dermitzakis1.   

Abstract

Recent developments in the collection and analysis of cellular multilayered data in large cohorts with extensive organismal phenotyping promise to reveal links between genetic variation and biological processes. The use of these cellular resources as models for human biology - known as 'cellular phenotyping' - is likely to transform our understanding of the genetic and long-term environmental influences on complex traits. I discuss the advantages and caveats of a deeper analysis of cellular phenotypes in large cohorts and assess the methodological advances, resource needs and prospects of this new approach.

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Year:  2012        PMID： 22330769     DOI： 10.1038/nrg3115

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  35 in total

1.  An integrative genomics approach to infer causal associations between gene expression and disease.

Authors:  Eric E Schadt; John Lamb; Xia Yang; Jun Zhu; Steve Edwards; Debraj Guhathakurta; Solveig K Sieberts; Stephanie Monks; Marc Reitman; Chunsheng Zhang; Pek Yee Lum; Amy Leonardson; Rolf Thieringer; Joseph M Metzger; Liming Yang; John Castle; Haoyuan Zhu; Shera F Kash; Thomas A Drake; Alan Sachs; Aldons J Lusis
Journal:  Nat Genet       Date:  2005-06-19       Impact factor: 38.330

Review 2.  The genetics of quantitative traits: challenges and prospects.

Authors:  Trudy F C Mackay; Eric A Stone; Julien F Ayroles
Journal:  Nat Rev Genet       Date:  2009-08       Impact factor: 53.242

Review 3.  Molecular networks as sensors and drivers of common human diseases.

Authors:  Eric E Schadt
Journal:  Nature       Date:  2009-09-10       Impact factor: 49.962

4.  From gene expression to disease risk.

Authors:  Emmanouil T Dermitzakis
Journal:  Nat Genet       Date:  2008-05       Impact factor: 38.330

5.  Genetics of gene expression and its effect on disease.

Authors:  Valur Emilsson; Gudmar Thorleifsson; Bin Zhang; Amy S Leonardson; Florian Zink; Jun Zhu; Sonia Carlson; Agnar Helgason; G Bragi Walters; Steinunn Gunnarsdottir; Magali Mouy; Valgerdur Steinthorsdottir; Gudrun H Eiriksdottir; Gyda Bjornsdottir; Inga Reynisdottir; Daniel Gudbjartsson; Anna Helgadottir; Aslaug Jonasdottir; Adalbjorg Jonasdottir; Unnur Styrkarsdottir; Solveig Gretarsdottir; Kristinn P Magnusson; Hreinn Stefansson; Ragnheidur Fossdal; Kristleifur Kristjansson; Hjortur G Gislason; Tryggvi Stefansson; Bjorn G Leifsson; Unnur Thorsteinsdottir; John R Lamb; Jeffrey R Gulcher; Marc L Reitman; Augustine Kong; Eric E Schadt; Kari Stefansson
Journal:  Nature       Date:  2008-03-16       Impact factor: 49.962

6.  A map of open chromatin in human pancreatic islets.

Authors:  Kyle J Gaulton; Takao Nammo; Lorenzo Pasquali; Jeremy M Simon; Paul G Giresi; Marie P Fogarty; Tami M Panhuis; Piotr Mieczkowski; Antonio Secchi; Domenico Bosco; Thierry Berney; Eduard Montanya; Karen L Mohlke; Jason D Lieb; Jorge Ferrer
Journal:  Nat Genet       Date:  2010-01-31       Impact factor: 38.330

7.  Relative impact of nucleotide and copy number variation on gene expression phenotypes.

Authors:  Barbara E Stranger; Matthew S Forrest; Mark Dunning; Catherine E Ingle; Claude Beazley; Natalie Thorne; Richard Redon; Christine P Bird; Anna de Grassi; Charles Lee; Chris Tyler-Smith; Nigel Carter; Stephen W Scherer; Simon Tavaré; Panagiotis Deloukas; Matthew E Hurles; Emmanouil T Dermitzakis
Journal:  Science       Date:  2007-02-09       Impact factor: 47.728

8.  Genetic analysis of radiation-induced changes in human gene expression.

Authors:  Denis A Smirnov; Michael Morley; Eunice Shin; Richard S Spielman; Vivian G Cheung
Journal:  Nature       Date:  2009-04-06       Impact factor: 49.962

9.  Somatic coding mutations in human induced pluripotent stem cells.

Authors:  Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

10.  A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs.

Authors:  Youssef Idaghdour; John D Storey; Sami J Jadallah; Greg Gibson
Journal:  PLoS Genet       Date:  2008-04-11       Impact factor: 5.917
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  22 in total

1.  Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.

Authors:  Yu Chen; Grazyna Palczewska; Debarshi Mustafi; Marcin Golczak; Zhiqian Dong; Osamu Sawada; Tadao Maeda; Akiko Maeda; Krzysztof Palczewski
Journal:  J Clin Invest       Date:  2013-11-15       Impact factor: 14.808

2.  Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity.

Authors:  Joseph C Maranville; Shaneen S Baxter; David B Witonsky; Meredith A Chase; Anna Di Rienzo
Journal:  Am J Hum Genet       Date:  2013-09-19       Impact factor: 11.025

3.  QuASAR: quantitative allele-specific analysis of reads.

Authors:  Chris T Harvey; Gregory A Moyerbrailean; Gordon O Davis; Xiaoquan Wen; Francesca Luca; Roger Pique-Regi
Journal:  Bioinformatics       Date:  2014-12-04       Impact factor: 6.937

Review 4.  The role of regulatory variation in complex traits and disease.

Authors:  Frank W Albert; Leonid Kruglyak
Journal:  Nat Rev Genet       Date:  2015-02-24       Impact factor: 53.242

5.  Towards a comprehensive picture of the genetic landscape of complex traits.

Authors:  Zhong Wang; Yaqun Wang; Ningtao Wang; Jianxin Wang; Zuoheng Wang; C Eduardo Vallejos; Rongling Wu
Journal:  Brief Bioinform       Date:  2012-08-27       Impact factor: 11.622

6.  Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes.

Authors:  Clement Y Chow; Mariana F Wolfner; Andrew G Clark
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-10       Impact factor: 11.205

Review 7.  Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.

Authors:  Maria Gutierrez-Arcelus; Stephen S Rich; Soumya Raychaudhuri
Journal:  Nat Rev Genet       Date:  2016-02-15       Impact factor: 53.242

8.  Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges.

Authors:  Eric R Gamazon; Minoli Perera
Journal:  Pharmacogenomics       Date:  2012-07       Impact factor: 2.533

Review 9.  Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.

Authors:  Swapan Kumar Das; Neeraj Kumar Sharma
Journal:  World J Diabetes       Date:  2014-04-15

10.  Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.

Authors:  João Fadista; Petter Vikman; Emilia Ottosson Laakso; Inês Guerra Mollet; Jonathan Lou Esguerra; Jalal Taneera; Petter Storm; Peter Osmark; Claes Ladenvall; Rashmi B Prasad; Karin B Hansson; Francesca Finotello; Kristina Uvebrant; Jones K Ofori; Barbara Di Camillo; Ulrika Krus; Corrado M Cilio; Ola Hansson; Lena Eliasson; Anders H Rosengren; Erik Renström; Claes B Wollheim; Leif Groop
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-08       Impact factor: 11.205
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