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Literature DB >> 21174217

Fetal environment, epigenetics, and pediatric renal disease.

Robert Woroniecki¹, Anil Bhanudas Gaikwad, Katalin Susztak.

Abstract

The notion that some adult diseases may have their origins in utero has recently captured scientists' attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 21174217 PMCID： PMC3063864 DOI： 10.1007/s00467-010-1714-8

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

45 in total

Review 1. X inactivation and the complexities of silencing a sex chromosome.

Authors: Jennifer Chow; Edith Heard
Journal: Curr Opin Cell Biol Date: 2009-05-26 Impact factor: 8.382

Review 2. Advances in early kidney specification, development and patterning.

Authors: Gregory R Dressler
Journal: Development Date: 2009-12 Impact factor: 6.868

3. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.

Authors: Hyenjong Hong; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Osami Kanagawa; Masato Nakagawa; Keisuke Okita; Shinya Yamanaka
Journal: Nature Date: 2009-08-09 Impact factor: 49.962

4. Methylation determines fibroblast activation and fibrogenesis in the kidney.

Authors: Wibke Bechtel; Scott McGoohan; Elisabeth M Zeisberg; Gerhard A Müller; Hubert Kalbacher; David J Salant; Claudia A Müller; Raghu Kalluri; Michael Zeisberg
Journal: Nat Med Date: 2010-04-25 Impact factor: 53.440

5. Cytosine methylation dysregulation in neonates following intrauterine growth restriction.

Authors: Francine Einstein; Reid F Thompson; Tushar D Bhagat; Melissa J Fazzari; Amit Verma; Nir Barzilai; John M Greally
Journal: PLoS One Date: 2010-01-26 Impact factor: 3.240

6. Human DNA methylomes at base resolution show widespread epigenomic differences.

Authors: Ryan Lister; Mattia Pelizzola; Robert H Dowen; R David Hawkins; Gary Hon; Julian Tonti-Filippini; Joseph R Nery; Leonard Lee; Zhen Ye; Que-Minh Ngo; Lee Edsall; Jessica Antosiewicz-Bourget; Ron Stewart; Victor Ruotti; A Harvey Millar; James A Thomson; Bing Ren; Joseph R Ecker
Journal: Nature Date: 2009-10-14 Impact factor: 49.962

7. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.

Authors: Sufyan G Sayyed; Anil Bhanudas Gaikwad; Julia Lichtnekert; Onkar Kulkarni; Dirk Eulberg; Sven Klussmann; Kulbhushan Tikoo; Hans-Joachim Anders
Journal: Nephrol Dial Transplant Date: 2010-01-12 Impact factor: 5.992

8. Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes.

Authors: Anil Bhanudas Gaikwad; Sufyan G Sayyed; Julia Lichtnekert; Kulbhushan Tikoo; Hans-Joachim Anders
Journal: Am J Pathol Date: 2010-01-14 Impact factor: 4.307

9. CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.

Authors: R Ariel Gomez; Ellen Steward Pentz; Xuan Jin; Magali Cordaillat; Maria Luisa S Sequeira Lopez
Journal: Am J Physiol Heart Circ Physiol Date: 2009-02-27 Impact factor: 4.733

Review 10. X inactivation and disease.

Authors: Ruben Agrelo; Anton Wutz
Journal: Semin Cell Dev Biol Date: 2009-10-06 Impact factor: 7.727

25 in total

Fetal environment, epigenetics, and pediatric renal disease.

Review 1. X inactivation and the complexities of silencing a sex chromosome.

Review 2. Advances in early kidney specification, development and patterning.

3. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.

4. Methylation determines fibroblast activation and fibrogenesis in the kidney.

5. Cytosine methylation dysregulation in neonates following intrauterine growth restriction.

6. Human DNA methylomes at base resolution show widespread epigenomic differences.

7. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.

8. Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes.

9. CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.

Review 10. X inactivation and disease.

Review 1. Genetic, environmental, and epigenetic factors involved in CAKUT.

2. Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice.

Review 3. Understanding the epigenetic syntax for the genetic alphabet in the kidney.

Review 4. Evolution, kidney development, and chronic kidney disease.

Review 5. Epigenetics and epigenomics in diabetic kidney disease and metabolic memory.

Review 6. The role of epigenetics in renal ageing.

7. Epigenetic unsilencing reverses renal fibrosis.

Review 8. PAX2 in human kidney malformations and disease.

Review 9. Genetic Considerations in Pediatric Chronic Kidney Disease.

Review 10. Techniques and Approaches to Genetic Analyses in Nephrological Disorders.