Literature DB >> 18568017

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

Danwei Huangfu1, René Maehr, Wenjun Guo, Astrid Eijkelenboom, Melinda Snitow, Alice E Chen, Douglas A Melton.   

Abstract

Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylase (HDAC) inhibitors improve reprogramming efficiency. In particular, valproic acid (VPA), an HDAC inhibitor, improves reprogramming efficiency by more than 100-fold, using Oct4-GFP as a reporter. VPA also enables efficient induction of pluripotent stem cells without introduction of the oncogene c-Myc.

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Year:  2008        PMID： 18568017      PMCID： PMC6334647          DOI： 10.1038/nbt1418

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  14 in total

1.  Allele-specific expression of imprinted genes in mouse migratory primordial germ cells.

Authors:  Piroska E Szabó; Karin Hübner; Hans Schöler; Jeffrey R Mann
Journal:  Mech Dev       Date:  2002-07       Impact factor: 1.882

2.  c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

Authors:  Marius Wernig; Alexander Meissner; John P Cassady; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2007-12-13       Impact factor: 24.633

3.  Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer.

Authors:  Satoshi Kishigami; Eiji Mizutani; Hiroshi Ohta; Takafusa Hikichi; Nguyen Van Thuan; Sayaka Wakayama; Hong-Thuy Bui; Teruhiko Wakayama
Journal:  Biochem Biophys Res Commun       Date:  2005-12-09       Impact factor: 3.575

4.  Generation of human induced pluripotent stem cells from dermal fibroblasts.

Authors:  W E Lowry; L Richter; R Yachechko; A D Pyle; J Tchieu; R Sridharan; A T Clark; K Plath
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-15       Impact factor: 11.205

5.  Reprogramming of human somatic cells to pluripotency with defined factors.

Authors:  In-Hyun Park; Rui Zhao; Jason A West; Akiko Yabuuchi; Hongguang Huo; Tan A Ince; Paul H Lerou; M William Lensch; George Q Daley
Journal:  Nature       Date:  2007-12-23       Impact factor: 49.962

6.  Induced pluripotent stem cell lines derived from human somatic cells.

Authors:  Junying Yu; Maxim A Vodyanik; Kim Smuga-Otto; Jessica Antosiewicz-Bourget; Jennifer L Frane; Shulan Tian; Jeff Nie; Gudrun A Jonsdottir; Victor Ruotti; Ron Stewart; Igor I Slukvin; James A Thomson
Journal:  Science       Date:  2007-11-20       Impact factor: 47.728

7.  Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer.

Authors:  Andrei Rybouchkin; Yoko Kato; Yukio Tsunoda
Journal:  Biol Reprod       Date:  2006-02-15       Impact factor: 4.285

8.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

9.  Generation of germline-competent induced pluripotent stem cells.

Authors:  Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

10.  Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.

Authors:  Robert Blelloch; Zhongde Wang; Alex Meissner; Steven Pollard; Austin Smith; Rudolf Jaenisch
Journal:  Stem Cells       Date:  2006-05-18       Impact factor: 6.277
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  627 in total

Review 1.  Generation of pluripotent stem cells without the use of genetic material.

Authors:  Akon Higuchi; Qing-Dong Ling; S Suresh Kumar; Murugan A Munusamy; Abdullah A Alarfaj; Yung Chang; Shih-Hsuan Kao; Ke-Chen Lin; Han-Chow Wang; Akihiro Umezawa
Journal:  Lab Invest       Date:  2014-11-03       Impact factor: 5.662

Review 2.  From microRNAs to targets: pathway discovery in cell fate transitions.

Authors:  Deepa Subramanyam; Robert Blelloch
Journal:  Curr Opin Genet Dev       Date:  2011-06-01       Impact factor: 5.578

3.  Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury.

Authors:  Ling Li; Rachel Black; Zhendong Ma; Qiwen Yang; Andrew Wang; Fangming Lin
Journal:  Am J Physiol Renal Physiol       Date:  2011-09-21

Review 4.  Regenerative chemical biology: current challenges and future potential.

Authors:  Ada Ao; Jijun Hao; Charles C Hong
Journal:  Chem Biol       Date:  2011-04-22

Review 5.  Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms.

Authors:  Brigitte Malgrange; Laurence Borgs; Benjamin Grobarczyk; Audrey Purnelle; Patricia Ernst; Gustave Moonen; Laurent Nguyen
Journal:  Cell Mol Life Sci       Date:  2010-10-26       Impact factor: 9.261

6.  Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.

Authors:  Fang Wang; Yu Yin; Xiaoying Ye; Kai Liu; Haiying Zhu; Lingling Wang; Maria Chiourea; Maja Okuka; Guangzhen Ji; Jiameng Dan; Bingfeng Zuo; Minshu Li; Qian Zhang; Na Liu; Lingyi Chen; Xinghua Pan; Sarantis Gagos; David L Keefe; Lin Liu
Journal:  Cell Res       Date:  2011-12-20       Impact factor: 25.617

Review 7.  Epigenetic landscape of pluripotent stem cells.

Authors:  Ji Woong Han; Young-sup Yoon
Journal:  Antioxid Redox Signal       Date:  2012-01-11       Impact factor: 8.401

Review 8.  Mechanisms underlying the formation of induced pluripotent stem cells.

Authors:  Federico González; Danwei Huangfu
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2015-09-18       Impact factor: 5.814

9.  Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame.

Authors:  Lijian Shao; Wei Feng; Yan Sun; Hao Bai; Jun Liu; Caroline Currie; Jaejung Kim; Rafael Gama; Zack Wang; Zhijian Qian; Lucy Liaw; Wen-Shu Wu
Journal:  Cell Res       Date:  2009-03       Impact factor: 25.617

10.  Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of "factor-free" induced pluripotent stem cells.

Authors:  Johannes Kuehle; Soeren Turan; Tobias Cantz; Dirk Hoffmann; Julia D Suerth; Tobias Maetzig; Daniela Zychlinski; Christoph Klein; Doris Steinemann; Christopher Baum; Juergen Bode; Axel Schambach
Journal:  Mol Ther       Date:  2014-01-17       Impact factor: 11.454
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