| Literature DB >> 19477133 |
Bastien Reux1, Tapio Nevalainen, Katri H Raitio, Ari M P Koskinen.
Abstract
A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB(2) receptor-dependent G-protein activities were determined using the [(35)S]GTPgammaS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB(2) receptor agonist activity, the most potent ligands being the 2-(Me(2)N)-phenyl substituted derivatives, which were also full agonists at the CB(2)-receptor.Entities:
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Year: 2009 PMID： 19477133 DOI： 10.1016/j.bmc.2009.05.013
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641