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Literature DB >> 19431797

Electrostatic modeling of dipole-ion interactions in gramicidinlike channels.

Abstract

Using an electrostatic model for the pore and membrane region in a gramicidinlike channel, the effect of dipoles located inside the membrane on the ion transport are analyzed. Calculated energy profiles for different orientations of dipoles show a predominant influence of their radial components. The results qualitatively agree with experimental measurements of conductance on different modified gramicidins and allow to understand the important role of polar side chains on ion permeation.

Entities: Chemical

Year: 1991 PMID： 19431797 PMCID： PMC1260040 DOI： 10.1016/S0006-3495(91)82032-X

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

16 in total

1. The theory of ion transport through membrane channels.

Authors: K Cooper; E Jakobsson; P Wolynes
Journal: Prog Biophys Mol Biol Date: 1985 Impact factor: 3.667

2. Why is gramicidin valence selective? A theoretical study.

Authors: S S Sung; P C Jordan
Journal: Biophys J Date: 1987-04 Impact factor: 4.033

Review 3. Interpretation of biological ion channel flux data--reaction-rate versus continuum theory.

Authors: D G Levitt
Journal: Annu Rev Biophys Biophys Chem Date: 1986

4. Transmembrane channel activity of gramicidin A analogs: effects of modification and deletion of the amino-terminal residue.

Authors: J S Morrow; W R Veatch; L Stryer
Journal: J Mol Biol Date: 1979-08-25 Impact factor: 5.469

5. Single channels of 9, 11, 13, 15-destryptophyl-phenylalanyl-gramicidin A.

Authors: F Heitz; G Spach; Y Trudelle
Journal: Biophys J Date: 1982-10 Impact factor: 4.033

6. The dimeric nature of the gramicidin A transmembrane channel: conductance and fluorescence energy transfer studies of hybrid channels.

Authors: W Veatch; L Stryer
Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

7. Electrostatic modeling of ion pores. Energy barriers and electric field profiles.

Authors: P C Jordan
Journal: Biophys J Date: 1982-08 Impact factor: 4.033

8. Single-channel parameters of gramicidin A,B, and C.

Authors: E Bamberg; K Noda; E Gross; P Läuger
Journal: Biochim Biophys Acta Date: 1976-01-21

9. Electrostatic calculations for an ion channel. I. Energy and potential profiles and interactions between ions.

Authors: D G Levitt
Journal: Biophys J Date: 1978-05 Impact factor: 4.033

10. The effect of the amino-acid side chains on the energy profiles for ion transport in the gramicidin A channel.

Authors: C Etchebest; A Pullman
Journal: J Biomol Struct Dyn Date: 1985-02

11 in total

1. Noncontact dipole effects on channel permeation. II. Trp conformations and dipole potentials in gramicidin A.

Authors: A E Dorigo; D G Anderson; D D Busath
Journal: Biophys J Date: 1999-04 Impact factor: 4.033

2. Model channel ion currents in NaCl-extended simple point charge water solution with applied-field molecular dynamics.

Authors: P S Crozier; D Henderson; R L Rowley; D D Busath
Journal: Biophys J Date: 2001-12 Impact factor: 4.033

3. Extended dipolar chain model for ion channels: electrostriction effects and the translocational energy barrier.

Authors: M Sancho; M B Partenskii; V Dorman; P C Jordan
Journal: Biophys J Date: 1995-02 Impact factor: 4.033

4. Influence of a channel-forming peptide on energy barriers to ion permeation, viewed from a continuum dielectric perspective.

Authors: M B Partenskii; V Dorman; P C Jordan
Journal: Biophys J Date: 1994-10 Impact factor: 4.033