OBJECTIVES/HYPOTHESIS: Our laboratory has developed an in vivo rabbit model to investigate the effects of phonation on expression and turnover of the vocal fold extracellular matrix. As a logical outgrowth of this research to include phonotrauma in the present study, we investigated the hypothesis that an increase in airflow rate delivered to the glottis produces a change in glottal configuration and an increase in mean phonation intensity. STUDY DESIGN: Prospective animal study. METHODS: Six New Zealand white breeder rabbits weighing 3 to 5 kg were used in this study. A rigid endoscope and camera were used to document glottal configuration. Acoustic signals of modal and raised phonation were recorded and digitized. Two separate one-way repeated measures analysis of variance (ANOVA) tests were used to investigate within subject differences in phonation intensity and fundamental frequency between modal and raised phonation. RESULTS: Phonation intensity was 54.19 dB SPL (6.21 standard deviations [SD]) during modal phonation, and 60.31 dB SPL (5.68 SD) during raised phonation. Endoscopic images revealed a convergent glottis, with greater separation of the vocal folds during raised phonation. Results of ANOVA revealed a significant within subjects effect for phonation intensity (P = .011). Pairwise comparisons revealed that phonation intensity increased significantly during raised phonation, compared to modal phonation (P = .008). No differences in mean fundamental frequency were observed between phonation conditions. CONCLUSIONS: Improved understanding of factors that control phonation output in the in vivo rabbit model will result in improved capabilities to match phonation dose across animals and provide immediate direction to future biochemical studies.
OBJECTIVES/HYPOTHESIS: Our laboratory has developed an in vivo rabbit model to investigate the effects of phonation on expression and turnover of the vocal fold extracellular matrix. As a logical outgrowth of this research to include phonotrauma in the present study, we investigated the hypothesis that an increase in airflow rate delivered to the glottis produces a change in glottal configuration and an increase in mean phonation intensity. STUDY DESIGN: Prospective animal study. METHODS: Six New Zealand white breeder rabbits weighing 3 to 5 kg were used in this study. A rigid endoscope and camera were used to document glottal configuration. Acoustic signals of modal and raised phonation were recorded and digitized. Two separate one-way repeated measures analysis of variance (ANOVA) tests were used to investigate within subject differences in phonation intensity and fundamental frequency between modal and raised phonation. RESULTS: Phonation intensity was 54.19 dB SPL (6.21 standard deviations [SD]) during modal phonation, and 60.31 dB SPL (5.68 SD) during raised phonation. Endoscopic images revealed a convergent glottis, with greater separation of the vocal folds during raised phonation. Results of ANOVA revealed a significant within subjects effect for phonation intensity (P = .011). Pairwise comparisons revealed that phonation intensity increased significantly during raised phonation, compared to modal phonation (P = .008). No differences in mean fundamental frequency were observed between phonation conditions. CONCLUSIONS: Improved understanding of factors that control phonation output in the in vivo rabbit model will result in improved capabilities to match phonation dose across animals and provide immediate direction to future biochemical studies.
Authors: Ingo R Titze; Robert W Hitchcock; Kelly Broadhead; Ken Webb; Wenhua Li; Steven D Gray; Patrick A Tresco Journal: J Biomech Date: 2004-10 Impact factor: 2.712
Authors: Bernard Rousseau; PingJiang Ge; Lesley C French; David L Zealear; Susan L Thibeault; Robert H Ossoff Journal: Otolaryngol Head Neck Surg Date: 2008-01 Impact factor: 3.497
Authors: Ping Jiang Ge; Lesley C French; Tsunehisa Ohno; David L Zealear; Bernard Rousseau Journal: Ann Otol Rhinol Laryngol Date: 2009-01 Impact factor: 1.547
Authors: Nelson Roy; Barbara Weinrich; Steven D Gray; Kristine Tanner; Sue Walker Toledo; Heather Dove; Kim Corbin-Lewis; Joseph C Stemple Journal: J Speech Lang Hear Res Date: 2002-08 Impact factor: 2.297
Authors: Erik R Swanson; Tsunehisa Ohno; Dave Abdollahian; C Gaelyn Garrett; Bernard Rousseau Journal: Otolaryngol Head Neck Surg Date: 2010-10 Impact factor: 3.497
Authors: Joseph E Hall; Atsushi Suehiro; Ryan C Branski; C Gaelyn Garrett; Bernard Rousseau Journal: Otolaryngol Head Neck Surg Date: 2012-03-07 Impact factor: 3.497
Authors: Allison L Maytag; Mark J Robitaille; Adam L Rieves; James Madsen; Benjamin L Smith; Jack J Jiang Journal: J Voice Date: 2012-11-15 Impact factor: 2.009
Authors: Masanobu Mizuta; Takashi Kurita; Neal P Dillon; Emily E Kimball; C Gaelyn Garrett; M Preeti Sivasankar; Robert J Webster; Bernard Rousseau Journal: Laryngoscope Date: 2017-06-02 Impact factor: 3.325
Authors: Tsuyoshi Kojima; Carla V Valenzuela; Carolyn K Novaleski; Mark Van Deusen; Joshua R Mitchell; C Gaelyn Garrett; M Preeti Sivasankar; Bernard Rousseau Journal: Laryngoscope Date: 2014-07-30 Impact factor: 3.325