Literature DB >> 19386916

Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation.

Charlotte J Stagg1, Jonathan G Best, Mary C Stephenson, Jacinta O'Shea, Marzena Wylezinska, Z Tamas Kincses, Peter G Morris, Paul M Matthews, Heidi Johansen-Berg.   

Abstract

Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.

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Year:  2009        PMID： 19386916      PMCID： PMC6665468          DOI： 10.1523/JNEUROSCI.4432-08.2009

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  28 in total

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Review 2.  Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects.

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Authors:  M A Nitsche; W Paulus
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Review 7.  In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics.

Authors:  D L Rothman; N R Sibson; F Hyder; J Shen; K L Behar; R G Shulman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-07-29       Impact factor: 6.237

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Authors:  David Liebetanz; Michael A Nitsche; Frithjof Tergau; Walter Paulus
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  300 in total

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Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2011-06-12       Impact factor: 9.795

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4.  Brain-computer interface: current and emerging rehabilitation applications.

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Journal:  Arch Phys Med Rehabil       Date:  2015-03       Impact factor: 3.966

5.  Visual Attention Modulates Glutamate-Glutamine Levels in Vestibular Cortex: Evidence from Magnetic Resonance Spectroscopy.

Authors:  Sebastian M Frank; Lisa Forster; Maja Pawellek; Wilhelm M Malloni; Sinyeob Ahn; Peter U Tse; Mark W Greenlee
Journal:  J Neurosci       Date:  2021-01-15       Impact factor: 6.167

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Journal:  J Neurosci       Date:  2010-03-24       Impact factor: 6.167

7.  Bihemispheric transcranial direct current stimulation enhances effector-independent representations of motor synergy and sequence learning.

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Journal:  J Neurosci       Date:  2014-01-15       Impact factor: 6.167

8.  The use of magnetic resonance spectroscopy as a tool for the measurement of bi-hemispheric transcranial electric stimulation effects on primary motor cortex metabolism.

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9.  Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels.

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10.  Neuroenhancement of the aging brain: restoring skill acquisition in old subjects.

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