Literature DB >> 22046466

What are we measuring with GABA magnetic resonance spectroscopy?

Charlotte J Stagg1, Velicia Bachtiar, Heidi Johansen-Berg.   

Abstract

A number of recent papers1-3 have demonstrated a relationship between in vivo concentration of GABA, as assessed using Magnetic Resonance Spectroscopy (MRS), and an individual's task performance, giving a unique insight into the relationship between physiology and behavior. However, interpretation of the functional significance of the MRS GABA measure is not straightforward. Here we discuss some of the outstanding questions as to how total concentration of GABA within a cortical region relates to phasic and tonic GABA activity within the cortical volume studied.

Entities:  

Keywords:  gamma-amino butyric acid (GABA); human; inter-individual differences; magnetic resonance spectroscopy; motor cortex

Year:  2011        PMID： 22046466      PMCID： PMC3204132          DOI： 10.4161/cib.4.5.16213

Source DB:  PubMed          Journal:  Commun Integr Biol        ISSN： 1942-0889


  14 in total

1.  Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex.

Authors:  Michael A Nitsche; Antje Seeber; Kai Frommann; Cornelia Carmen Klein; Christian Rochford; Maren S Nitsche; Kristina Fricke; David Liebetanz; Nicolas Lang; Andrea Antal; Walter Paulus; Frithjof Tergau
Journal:  J Physiol       Date:  2005-07-07       Impact factor: 5.182

2.  Theta burst stimulation of the human motor cortex.

Authors:  Ying-Zu Huang; Mark J Edwards; Elisabeth Rounis; Kailash P Bhatia; John C Rothwell
Journal:  Neuron       Date:  2005-01-20       Impact factor: 17.173

3.  Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans.

Authors:  K J Werhahn; E Kunesch; S Noachtar; R Benecke; J Classen
Journal:  J Physiol       Date:  1999-06-01       Impact factor: 5.182

4.  Individual differences in subconscious motor control predicted by GABA concentration in SMA.

Authors:  Frederic Boy; C John Evans; Richard A E Edden; Krish D Singh; Masud Husain; Petroc Sumner
Journal:  Curr Biol       Date:  2010-09-30       Impact factor: 10.834

5.  Differential modulation of motor cortical plasticity and excitability in early and late phases of human motor learning.

Authors:  Karin Rosenkranz; Aleksandra Kacar; John C Rothwell
Journal:  J Neurosci       Date:  2007-10-31       Impact factor: 6.167

6.  Rapid modulation of GABA in sensorimotor cortex induced by acute deafferentation.

Authors:  Lucien M Levy; Ulf Ziemann; Robert Chen; Leonardo G Cohen
Journal:  Ann Neurol       Date:  2002-12       Impact factor: 10.422

Review 7.  Regulation of gamma-aminobutyric acid synthesis in the brain.

Authors:  D L Martin; K Rimvall
Journal:  J Neurochem       Date:  1993-02       Impact factor: 5.372

8.  Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation.

Authors:  Charlotte J Stagg; Jonathan G Best; Mary C Stephenson; Jacinta O'Shea; Marzena Wylezinska; Z Tamas Kincses; Peter G Morris; Paul M Matthews; Heidi Johansen-Berg
Journal:  J Neurosci       Date:  2009-04-22       Impact factor: 6.167

9.  Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy.

Authors:  C J Stagg; M Wylezinska; P M Matthews; H Johansen-Berg; P Jezzard; J C Rothwell; S Bestmann
Journal:  J Neurophysiol       Date:  2009-04-01       Impact factor: 2.714

Review 10.  Extrasynaptic GABAA receptors: form, pharmacology, and function.

Authors:  Delia Belelli; Neil L Harrison; Jamie Maguire; Robert L Macdonald; Matthew C Walker; David W Cope
Journal:  J Neurosci       Date:  2009-10-14       Impact factor: 6.167
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  55 in total

1.  Big GABA: Edited MR spectroscopy at 24 research sites.

Authors:  Mark Mikkelsen; Peter B Barker; Pallab K Bhattacharyya; Maiken K Brix; Pieter F Buur; Kim M Cecil; Kimberly L Chan; David Y-T Chen; Alexander R Craven; Koen Cuypers; Michael Dacko; Niall W Duncan; Ulrike Dydak; David A Edmondson; Gabriele Ende; Lars Ersland; Fei Gao; Ian Greenhouse; Ashley D Harris; Naying He; Stefanie Heba; Nigel Hoggard; Tun-Wei Hsu; Jacobus F A Jansen; Alayar Kangarlu; Thomas Lange; R Marc Lebel; Yan Li; Chien-Yuan E Lin; Jy-Kang Liou; Jiing-Feng Lirng; Feng Liu; Ruoyun Ma; Celine Maes; Marta Moreno-Ortega; Scott O Murray; Sean Noah; Ralph Noeske; Michael D Noseworthy; Georg Oeltzschner; James J Prisciandaro; Nicolaas A J Puts; Timothy P L Roberts; Markus Sack; Napapon Sailasuta; Muhammad G Saleh; Michael-Paul Schallmo; Nicholas Simard; Stephan P Swinnen; Martin Tegenthoff; Peter Truong; Guangbin Wang; Iain D Wilkinson; Hans-Jörg Wittsack; Hongmin Xu; Fuhua Yan; Chencheng Zhang; Vadim Zipunnikov; Helge J Zöllner; Richard A E Edden
Journal:  Neuroimage       Date:  2017-07-14       Impact factor: 6.556

2.  Increase in glutamate/glutamine concentration in the medial prefrontal cortex during mental imagery: A combined functional mrs and fMRI study.

Authors:  Zirui Huang; Henry Hap Davis; Qiang Yue; Christine Wiebking; Niall W Duncan; Jianfeng Zhang; Nils-Frederic Wagner; Annemarie Wolff; Georg Northoff
Journal:  Hum Brain Mapp       Date:  2015-06-09       Impact factor: 5.038

Review 3.  GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies.

Authors:  Marisa M Silveri
Journal:  Pharmacol Ther       Date:  2014-03-11       Impact factor: 12.310

4.  Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis.

Authors:  Fei Gao; Xuntao Yin; Richard A E Edden; Alan C Evans; Junhai Xu; Guanmei Cao; Honghao Li; Muwei Li; Bin Zhao; Jian Wang; Guangbin Wang
Journal:  Hippocampus       Date:  2018-11       Impact factor: 3.899

5.  Investigation of brain GABA+ in primary hypothyroidism using edited proton MR spectroscopy.

Authors:  Bo Liu; Huan Yang; Fei Gao; Qing Wang; Bin Zhao; Tao Gong; Zhensong Wang; Weibo Chen; Guangbin Wang; Richard A E Edden
Journal:  Clin Endocrinol (Oxf)       Date:  2016-09-26       Impact factor: 3.478

6.  GABA metabolism and its role in gamma-band oscillatory activity during auditory processing: An MRS and EEG study.

Authors:  Christine Wyss; Desmond H Y Tse; Michael Kometer; Jürgen Dammers; Rita Achermann; N Jon Shah; Wolfram Kawohl; Irene Neuner
Journal:  Hum Brain Mapp       Date:  2017-05-08       Impact factor: 5.038

7.  Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder.

Authors:  Tamar Kolodny; Michael-Paul Schallmo; Jennifer Gerdts; Richard A E Edden; Raphael A Bernier; Scott O Murray
Journal:  Autism Res       Date:  2020-04-16       Impact factor: 5.216

8.  Relationship between transcranial magnetic stimulation measures of intracortical inhibition and spectroscopy measures of GABA and glutamate+glutamine.

Authors:  Sara Tremblay; Vincent Beaulé; Sébastien Proulx; Louis de Beaumont; Malgorzata Marjanska; Julien Doyon; Alvaro Pascual-Leone; Maryse Lassonde; Hugo Théoret
Journal:  J Neurophysiol       Date:  2012-12-05       Impact factor: 2.714

9.  Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy.

Authors:  Isabelle M Rosso; Melissa R Weiner; David J Crowley; Marisa M Silveri; Scott L Rauch; J Eric Jensen
Journal:  Depress Anxiety       Date:  2013-07-16       Impact factor: 6.505

10.  Individual differences in the balance of GABA to glutamate in pFC predict the ability to select among competing options.

Authors:  Alejandro de la Vega; Mark S Brown; Hannah R Snyder; Debra Singel; Yuko Munakata; Marie T Banich
Journal:  J Cogn Neurosci       Date:  2014-04-17       Impact factor: 3.225
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