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Literature DB >> 19288212

Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance.

Abstract

Damaged DNA Binding protein 1 (DDB1) is a conserved protein and a component of multiple cellular complexes. Arabidopsis has two homologues of DDB1: DDB1A and DDB1B. In this study we examine the role of DDB1A in Arabidopsis UV tolerance and DNA repair using a DDB1A null mutant (ddb1a) and overexpression lines. DDB1A overexpression lines showed higher levels of UV-resistance than wild-type in a range of assays as well as faster DNA repair. However a significant difference between wild-type plants and ddb1a mutants was only observed immediately following UV treatment in root length and photoproduct repair assays. DDB1A and DDB1B mRNA levels increased 3 h after UV exposure and DDB1A is required for UV regulation of DDB1B and DDB2 mRNA levels. In conclusion, while DDB1A is sufficient to increase Arabidopsis UV tolerance, it is only necessary for immediate response to UV damage.

Entities: Gene Species

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Substances：

Year: 2009 PMID： 19288212 DOI： 10.1007/s11103-009-9479-9

Source DB: PubMed Journal: Plant Mol Biol ISSN： 0167-4412 Impact factor: 4.076

65 in total

1. DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells.

Authors: Mitsuo Wakasugi; Kenkyo Matsuura; Atsushi Nagasawa; DongTao Fu; Hiroko Shimizu; Ken-ichi Yamamoto; Shunichi Takeda; Tsukasa Matsunaga
Journal: Biochem Biophys Res Commun Date: 2007-10-22 Impact factor: 3.575

Review 2. DNA repair in plants.

Authors: Seisuke Kimura; Kengo Sakaguchi
Journal: Chem Rev Date: 2006-02 Impact factor: 60.622

Review 3. Molecular mechanisms of mammalian global genome nucleotide excision repair.

Authors: Ludovic C J Gillet; Orlando D Schärer
Journal: Chem Rev Date: 2006-02 Impact factor: 60.622

4. Characterization of DNA recognition by the human UV-damaged DNA-binding protein.

Authors: Y Fujiwara; C Masutani; T Mizukoshi; J Kondo; F Hanaoka; S Iwai
Journal: J Biol Chem Date: 1999-07-09 Impact factor: 5.157

Review 5. Repair of DNA damage induced by ultraviolet radiation.

Authors: A B Britt
Journal: Plant Physiol Date: 1995-07 Impact factor: 8.340

6. DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity.

Authors: Jinyou Li; Qi-En Wang; Qianzheng Zhu; Mohamed A El-Mahdy; Gulzar Wani; Mette Praetorius-Ibba; Altaf A Wani
Journal: Cancer Res Date: 2006-09-01 Impact factor: 12.701

7. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.

Authors: Yong Cang; Jianxuan Zhang; Sally A Nicholas; Jayson Bastien; Baojie Li; Pengbo Zhou; Stephen P Goff
Journal: Cell Date: 2006-12-01 Impact factor: 41.582

8. Identification of unstable transcripts in Arabidopsis by cDNA microarray analysis: rapid decay is associated with a group of touch- and specific clock-controlled genes.

Authors: Rodrigo A Gutierrez; Rob M Ewing; J Michael Cherry; Pamela J Green
Journal: Proc Natl Acad Sci U S A Date: 2002-08-07 Impact factor: 11.205

9. Arabidopsis UVH6, a homolog of human XPD and yeast RAD3 DNA repair genes, functions in DNA repair and is essential for plant growth.

Authors: Zongrang Liu; Suk-Whan Hong; Mindy Escobar; Elizabeth Vierling; David L Mitchell; David W Mount; Jennifer D Hall
Journal: Plant Physiol Date: 2003-07 Impact factor: 8.340

10. Phototropin 1 is required for high-fluence blue-light-mediated mRNA destabilization.

Authors: Kevin M Folta; Lon S Kaufman
Journal: Plant Mol Biol Date: 2003-03 Impact factor: 4.076

16 in total

1. Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.

Authors: Christina M Choi; William M Gray; Sutton Mooney; Hanjo Hellmann
Journal: Arabidopsis Book Date: 2014-11-17

2. Arabidopsis cockayne syndrome A-like proteins 1A and 1B form a complex with CULLIN4 and damage DNA binding protein 1A and regulate the response to UV irradiation.

Authors: Caiguo Zhang; Huiping Guo; Jun Zhang; Guangqin Guo; Karen S Schumaker; Yan Guo
Journal: Plant Cell Date: 2010-07-09 Impact factor: 11.277

Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance.

1. DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells.

Review 2. DNA repair in plants.

Review 3. Molecular mechanisms of mammalian global genome nucleotide excision repair.

4. Characterization of DNA recognition by the human UV-damaged DNA-binding protein.

Review 5. Repair of DNA damage induced by ultraviolet radiation.

6. DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity.

7. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.

8. Identification of unstable transcripts in Arabidopsis by cDNA microarray analysis: rapid decay is associated with a group of touch- and specific clock-controlled genes.

9. Arabidopsis UVH6, a homolog of human XPD and yeast RAD3 DNA repair genes, functions in DNA repair and is essential for plant growth.

10. Phototropin 1 is required for high-fluence blue-light-mediated mRNA destabilization.

1. Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.

2. Arabidopsis cockayne syndrome A-like proteins 1A and 1B form a complex with CULLIN4 and damage DNA binding protein 1A and regulate the response to UV irradiation.

Review 3. Protecting DNA from errors and damage: an overview of DNA repair mechanisms in plants compared to mammals.

4. Arabidopsis DDB1a and DDB1b are critical for embryo development.

5. The conserved factor DE-ETIOLATED 1 cooperates with CUL4-DDB1DDB2 to maintain genome integrity upon UV stress.

6. Plants genotoxicity as pollution bioindicator in Jordan using comet assay.

7. Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1.

Review 8. CRL4s: the CUL4-RING E3 ubiquitin ligases.

9. Genome-Wide Association Study for Ultraviolet-B Resistance in Soybean (Glycine max L.).

10. Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1.