Literature DB >> 19269883

Control of radical chemistry in the AdoMet radical enzymes.

Kaitlin S Duschene1, Susan E Veneziano, Sunshine C Silver, Joan B Broderick.   

Abstract

The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. The intricate control these enzymes exercise over the radical transformations they catalyze is an amazing feat of elegance and sophistication in biochemistry. This review focuses on the accumulating evidence for how these enzymes control this remarkable chemistry, including controlling the reactivity between the iron-sulfur cluster and AdoMet, and controlling the subsequent radical transformations.

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Year:  2009        PMID： 19269883      PMCID： PMC2703739          DOI： 10.1016/j.cbpa.2009.01.022

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  35 in total

1.  Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.

Authors:  Petra Hänzelmann; Hermann Schindelin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-21       Impact factor: 11.205

2.  Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme.

Authors:  Frederick Berkovitch; Yvain Nicolet; Jason T Wan; Joseph T Jarrett; Catherine L Drennan
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

3.  Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates.

Authors:  J Carsten Pieck; Ulrich Hennecke; Antonio J Pierik; Marcus G Friedel; Thomas Carell
Journal:  J Biol Chem       Date:  2006-09-11       Impact factor: 5.157

Review 4.  The Radical SAM Superfamily.

Authors:  Perry A Frey; Adrian D Hegeman; Frank J Ruzicka
Journal:  Crit Rev Biochem Mol Biol       Date:  2008 Jan-Feb       Impact factor: 8.250

5.  How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy.

Authors:  Nicholas S Lees; Dawei Chen; Charles J Walsby; Elham Behshad; Perry A Frey; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2006-08-09       Impact factor: 15.419

6.  The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale.

Authors:  Bryan W Lepore; Frank J Ruzicka; Perry A Frey; Dagmar Ringe
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-15       Impact factor: 11.205

7.  X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima.

Authors:  Yvain Nicolet; Jon K Rubach; Matthew C Posewitz; Patricia Amara; Carole Mathevon; Mohamed Atta; Marc Fontecave; Juan C Fontecilla-Camps
Journal:  J Biol Chem       Date:  2008-04-08       Impact factor: 5.157

8.  Cofactor dependence of reduction potentials for [4Fe-4S]2+/1+ in lysine 2,3-aminomutase.

Authors:  Glen T Hinckley; Perry A Frey
Journal:  Biochemistry       Date:  2006-03-14       Impact factor: 3.162

9.  Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme.

Authors:  Susan C Wang; Perry A Frey
Journal:  Biochemistry       Date:  2007-10-18       Impact factor: 3.162

10.  Radical S-adenosylmethionine enzyme coproporphyrinogen III oxidase HemN: functional features of the [4Fe-4S] cluster and the two bound S-adenosyl-L-methionines.

Authors:  Gunhild Layer; Katrin Grage; Thomas Teschner; Volker Schünemann; Daniela Breckau; Ava Masoumi; Martina Jahn; Peter Heathcote; Alfred X Trautwein; Dieter Jahn
Journal:  J Biol Chem       Date:  2005-06-20       Impact factor: 5.157
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  35 in total

1.  EPR spin trapping of an oxalate-derived free radical in the oxalate decarboxylase reaction.

Authors:  Witcha Imaram; Benjamin T Saylor; Christopher P Centonze; Nigel G J Richards; Alexander Angerhofer
Journal:  Free Radic Biol Med       Date:  2011-01-26       Impact factor: 7.376

2.  Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose.

Authors:  Mark W Ruszczycky; Sei-hyun Choi; Steven O Mansoorabadi; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2011-04-22       Impact factor: 15.419

3.  The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.

Authors:  Leif Flühe; Thomas A Knappe; Michael J Gattner; Antje Schäfer; Olaf Burghaus; Uwe Linne; Mohamed A Marahiel
Journal:  Nat Chem Biol       Date:  2012-02-26       Impact factor: 15.040

4.  Mechanistic Enzymology of the Radical SAM Enzyme DesII.

Authors:  Mark W Ruszczycky; Hung-Wen Liu
Journal:  Isr J Chem       Date:  2015-02-20       Impact factor: 3.333

Review 5.  Emerging themes in radical SAM chemistry.

Authors:  Krista A Shisler; Joan B Broderick
Journal:  Curr Opin Struct Biol       Date:  2012-11-08       Impact factor: 6.809

6.  EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII.

Authors:  Mark W Ruszczycky; Sei-hyun Choi; Hung-wen Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-17       Impact factor: 11.205

7.  Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase.

Authors:  Simon Arragain; Ricardo Garcia-Serres; Geneviève Blondin; Thierry Douki; Martin Clemancey; Jean-Marc Latour; Farhad Forouhar; Helen Neely; Gaetano T Montelione; John F Hunt; Etienne Mulliez; Marc Fontecave; Mohamed Atta
Journal:  J Biol Chem       Date:  2009-12-09       Impact factor: 5.157

Review 8.  Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives.

Authors:  Janice R Sufrin; Steven Finckbeiner; Colin M Oliver
Journal:  Mar Drugs       Date:  2009-08-26       Impact factor: 5.118

9.  Mechanistic and functional versatility of radical SAM enzymes.

Authors:  Squire J Booker; Tyler L Grove
Journal:  F1000 Biol Rep       Date:  2010-07-14

10.  4-Hydroxyphenylacetate decarboxylase activating enzyme catalyses a classical S-adenosylmethionine reductive cleavage reaction.

Authors:  Brinda Selvaraj; Antonio J Pierik; Eckhard Bill; Berta M Martins
Journal:  J Biol Inorg Chem       Date:  2013-05-29       Impact factor: 3.358
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