UNLABELLED: The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements. METHODS: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. RESULTS: There was no significant difference in repeated rest MBF (0.77+/-0.25 vs. 0.82+/-0.25 mL/min/g, P=0.31; mean difference, 6.18%+/-12.22%) or repeated hyperemic MBF (3.35+/-1.37 vs. 3.39+/-1.37 mL/min/g, P=0.81; mean difference, 1.17%+/-13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. CONCLUSION: MBF using 82Rb is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.
UNLABELLED: The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements. METHODS: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. RESULTS: There was no significant difference in repeated rest MBF (0.77+/-0.25 vs. 0.82+/-0.25 mL/min/g, P=0.31; mean difference, 6.18%+/-12.22%) or repeated hyperemic MBF (3.35+/-1.37 vs. 3.39+/-1.37 mL/min/g, P=0.81; mean difference, 1.17%+/-13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. CONCLUSION: MBF using 82Rb is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.
Authors: Ran Klein; Jennifer M Renaud; Maria C Ziadi; Stephanie L Thorn; Andy Adler; Rob S Beanlands; Robert A deKemp Journal: J Nucl Cardiol Date: 2010-04-13 Impact factor: 5.952
Authors: Keiichiro Yoshinaga; Osamu Manabe; Chietsugu Katoh; Li Chen; Ran Klein; Masanao Naya; Robert A deKemp; Kathryn Williams; Rob S B Beanlands; Nagara Tamaki Journal: Eur J Nucl Med Mol Imaging Date: 2010-07-13 Impact factor: 9.236
Authors: Jonathan B Moody; Benjamin C Lee; James R Corbett; Edward P Ficaro; Venkatesh L Murthy Journal: J Nucl Cardiol Date: 2015-04-14 Impact factor: 5.952