Literature DB >> 19036476

Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.

V Padmavathi1, G Sudhakar Reddy, A Padmaja, P Kondaiah.   

Abstract

A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity.

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Year:  2008        PMID： 19036476     DOI： 10.1016/j.ejmech.2008.10.012

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  21 in total

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Journal:  Mol Divers       Date:  2022-09-24       Impact factor: 3.364

2.  3-[(N-Methyl-anilino)meth-yl]-5-(thio-phen-2-yl)-1,3,4-oxadiazole-2(3H)-thione.

Authors:  Ali A El-Emam; Mohamed A Al-Omar; Hazem A Ghabbour; Hoong-Kun Fun; Tze Shyang Chia
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-04-13

3.  5-(4-Methyl-phen-yl)-1,3,4-oxadiazol-2-amine.

Authors:  Juan Zheng; Wen-Juan Li; Manman Song; Yan Xu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-12

4.  NMK-TD-100, a novel microtubule modulating agent, blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin.

Authors:  Surela Bhattacharya; N Maruthi Kumar; Arnab Ganguli; Mukund P Tantak; Dalip Kumar; Gopal Chakrabarti
Journal:  PLoS One       Date:  2013-10-07       Impact factor: 3.240

5.  2,2'-[(1,3,4-Thia-diazole-2,5-di-yl)bis-(sulfanedi-yl)]diaceto-nitrile.

Authors:  Joel T Mague; Mehmet Akkurt; Shaaban K Mohamed; Ahmed M M El-Saghier; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-11-30

6.  Anti-Helicobacter pylori activity and Structure-Activity Relationship study of 2-Alkylthio-5-(nitroaryl)-1,3,4-thiadiazole Derivatives.

Authors:  Ali Asadipour; Najmeh Edraki; Maryam Nakhjiri; Azadeh Yahya-Meymandi; Eskandar Alipour; Parastoo Saniee; Farideh Siavoshi; Abbas Shafiee; Alireza Foroumadi
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

7.  Structural features of the carbon-sulfur chemical bond: a semi-experimental perspective.

Authors:  Emanuele Penocchio; Marco Mendolicchio; Nicola Tasinato; Vincenzo Barone
Journal:  Can J Chem       Date:  2016-07-28       Impact factor: 1.118

Review 8.  Triazole analogues as potential pharmacological agents: a brief review.

Authors:  Sachin Kumar; Sukhbir Lal Khokra; Akash Yadav
Journal:  Futur J Pharm Sci       Date:  2021-05-25

9.  Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives.

Authors:  Lukasz Popiołek; Urszula Kosikowska; Liliana Mazur; Maria Dobosz; Anna Malm
Journal:  Med Chem Res       Date:  2012-11-11       Impact factor: 1.965

10.  Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line.

Authors:  Selvaraj Jubie; Palanisamy Dhanabal; Mohammed Afzal Azam; Nithyanantham Muruganantham; Rajagopal Kalirajan; Kannan Elango
Journal:  Lipids Health Dis       Date:  2013-03-28       Impact factor: 3.876
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