Literature DB >> 18959442

Actin-aggregating cucurbitacins from Physocarpus capitatus.

Katherine N Maloney1, Masaki Fujita, Ulrike S Eggert, Frank C Schroeder, Christine M Field, Timothy J Mitchison, Jon Clardy.   

Abstract

Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18959442      PMCID： PMC2891781          DOI： 10.1021/np8005259

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

Review 1.  Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton.

Authors:  Jeffrey R Peterson; Timothy J Mitchison
Journal:  Chem Biol       Date:  2002-12

2.  Cucurbitacin E targets proliferating endothelia.

Authors:  M D Duncan; K L Duncan
Journal:  J Surg Res       Date:  1997-04       Impact factor: 2.192

Review 3.  Understanding and controlling the cell cycle with natural products.

Authors:  D T Hung; T F Jamison; S L Schreiber
Journal:  Chem Biol       Date:  1996-08

Review 4.  Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy.

Authors:  David J Newman; Gordon M Cragg; Susan Holbeck; Edward A Sausville
Journal:  Curr Cancer Drug Targets       Date:  2002-12       Impact factor: 3.428

Review 5.  Whole cell assays in screening for biologically active substances.

Authors:  R P Hertzberg
Journal:  Curr Opin Biotechnol       Date:  1993-02       Impact factor: 9.740

6.  STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.

Authors:  Angela Graness; Valeria Poli; Margarete Goppelt-Struebe
Journal:  Biochem Pharmacol       Date:  2006-04-25       Impact factor: 5.858

7.  Plant anticancer agents, XXXIV. Cucurbitacins from Elaeocarpus dolichostylus.

Authors:  X Fang; C H Phoebe; J M Pezzuto; H H Fong; N R Farnsworth; B Yellin; S M Hecht
Journal:  J Nat Prod       Date:  1984 Nov-Dec       Impact factor: 4.050

8.  Cucurbitacins, cell adhesion inhibitors from Conobea scoparioides.

Authors:  L L Musza; P Speight; S McElhiney; C J Barrow; A M Gillum; R Cooper; L M Killar
Journal:  J Nat Prod       Date:  1994-11       Impact factor: 4.050

9.  Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament.

Authors:  Keiko Momma; Yuko Masuzawa; Naomi Nakai; Moeko Chujo; Akira Murakami; Noriyuki Kioka; Yasunori Kiyama; Toru Akita; Masaya Nagao
Journal:  Cytotechnology       Date:  2007-11-07       Impact factor: 2.058

10.  Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.

Authors:  Ulrike S Eggert; Amy A Kiger; Constance Richter; Zachary E Perlman; Norbert Perrimon; Timothy J Mitchison; Christine M Field
Journal:  PLoS Biol       Date:  2004-10-05       Impact factor: 8.029
View more
  5 in total

1.  The natural product cucurbitacin E inhibits depolymerization of actin filaments.

Authors:  Pia M Sörensen; Roxana E Iacob; Marco Fritzsche; John R Engen; William M Brieher; Guillaume Charras; Ulrike S Eggert
Journal:  ACS Chem Biol       Date:  2012-07-09       Impact factor: 5.100

2.  Computer-assisted methods for molecular structure elucidation: realizing a spectroscopist's dream.

Authors:  Mikhail Elyashberg; Kirill Blinov; Sergey Molodtsov; Yegor Smurnyy; Antony J Williams; Tatiana Churanova
Journal:  J Cheminform       Date:  2009-03-17       Impact factor: 5.514

3.  Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.

Authors:  Cynthia Lopez-Haber; Marcelo G Kazanietz
Journal:  Mol Pharmacol       Date:  2013-03-11       Impact factor: 4.436

4.  Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.

Authors:  David A Knecht; Rebecca A LaFleur; Alem W Kahsai; Christian E Argueta; Anwar B Beshir; Gabriel Fenteany
Journal:  PLoS One       Date:  2010-11-24       Impact factor: 3.240

5.  Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation.

Authors:  C Boykin; G Zhang; Y-H Chen; R-W Zhang; X-E Fan; W-M Yang; Q Lu
Journal:  Br J Cancer       Date:  2011-02-08       Impact factor: 7.640
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.