Literature DB >> 7763399

Whole cell assays in screening for biologically active substances.

R P Hertzberg1.   

Abstract

This past year has seen a number of new developments in recombinant cell based assays. Lead compounds are beginning to be identified using mechanism-based whole cell assays to discover inhibitors of cellular processes, such as transactivation and signaling. These assays offer advantages for many targets over subcellular assay systems with purified macromolecules.

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Year:  1993        PMID： 7763399     DOI： 10.1016/0958-1669(93)90037-w

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  3 in total

Review 1.  Search and discovery strategies for biotechnology: the paradigm shift.

Authors:  A T Bull; A C Ward; M Goodfellow
Journal:  Microbiol Mol Biol Rev       Date:  2000-09       Impact factor: 11.056

2.  A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays.

Authors:  S Tugendreich; E Perkins; J Couto; P Barthmaier; D Sun; S Tang; S Tulac; A Nguyen; E Yeh; A Mays; E Wallace; T Lila; D Shivak; M Prichard; L Andrejka; R Kim; T Melese
Journal:  Genome Res       Date:  2001-11       Impact factor: 9.043

3.  Actin-aggregating cucurbitacins from Physocarpus capitatus.

Authors:  Katherine N Maloney; Masaki Fujita; Ulrike S Eggert; Frank C Schroeder; Christine M Field; Timothy J Mitchison; Jon Clardy
Journal:  J Nat Prod       Date:  2008-10-29       Impact factor: 4.050
  3 in total

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