Literature DB >> 18855218

Antiproliferative compounds of Artabotrys madagascariensis from the Madagascar rainforest.

Brian T Murphy1, Shugeng Cao, Peggy J Brodie, James S Miller, Fidy Ratovoson, Chris Birkinshaw, Etienne Rakotobe, Vincent E Rasamison, Karen Tendyke, Edward M Suh, David G I Kingston.   

Abstract

Bioassay-guided fractionation of an ethanol extract of Artabotrys madagascariensis led to the isolation of the new compound artabotrene (1), two butenolides (2 and 3), and the tetracyclic triterpene polycarpol (4). Structure elucidation was determined on the basis of one and two-dimensional NMR, and absolute configuration of compounds 2-4 was verified by analysis of CD and optical rotation spectra. Two of the isolates, melodorinol (2) and acetylmelodorinol (3), were found to display antiproliferative activity against five different tumour cell lines with IC50 values ranging from 2.4 to 12 microM.

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Year:  2008        PMID： 18855218      PMCID： PMC2786269          DOI： 10.1080/14786410701726525

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  9 in total

1.  Isolation of flavonol glycosides from the leaves of Artabotrys odoratissmus.

Authors:  A P Singh; M Sahai
Journal:  Planta Med       Date:  1996-04       Impact factor: 3.352

2.  Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.

Authors:  Shugeng Cao; Peggy J Brodie; James S Miller; Fidy Ratovoson; Chris Birkinshaw; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-03-10       Impact factor: 4.050

3.  beta-Methoxy-gamma-methylene-alpha,beta-unsaturated-gamma-butyrolactones from Artabotrys hexapetalus.

Authors:  Ho Fai Wong; Geoffrey D Brown
Journal:  Phytochemistry       Date:  2002-01       Impact factor: 4.072

4.  Antifilarial activity in vitro of polycarpol and 3-O-acetyl aleuritolic acid from cameroonian medicinal plants against Onchocerca gutturosa.

Authors:  B Nyasse; I Ngantchou; J-J Nono; B Schneider
Journal:  Nat Prod Res       Date:  2006-04       Impact factor: 2.861

5.  Tumor inhibitors. XLV. Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from Croton macrostachys.

Authors:  S M Kupchan; R J Hemingway; R M Smith
Journal:  J Org Chem       Date:  1969-12       Impact factor: 4.354

6.  Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.

Authors:  Hiranthi Jayasuriya; Kithsiri B Herath; John G Ondeyka; Ziqiang Guan; Robert P Borris; Suroojnauth Tiwari; Wil de Jong; Flor Chavez; Jeremy Moss; Dennis W Stevenson; Hans T Beck; Marc Slattery; Nelson Zamora; Marvin Schulman; Aisha Ali; Neelam Sharma; Karen MacNaul; Nancy Hayes; John G Menke; Sheo B Singh
Journal:  J Nat Prod       Date:  2005-08       Impact factor: 4.050

7.  Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest.

Authors:  Sampada Karkare; Eba Adou; Shugeng Cao; Peggy Brodie; James S Miller; N M Andrianjafy; J Razafitsalama; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-11-08       Impact factor: 4.050

8.  Additional bioactive heptenes from Melodorum fruticosum.

Authors:  J H Jung; C J Chang; D L Smith; J L McLaughlin; S Pummangura; C Chaichantipyuth; C Patarapanich
Journal:  J Nat Prod       Date:  1991 Mar-Apr       Impact factor: 4.050

9.  Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

Authors:  K G Louie; B C Behrens; T J Kinsella; T C Hamilton; K R Grotzinger; W M McKoy; M A Winker; R F Ozols
Journal:  Cancer Res       Date:  1985-05       Impact factor: 12.701
  9 in total
  5 in total

1.  Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis.

Authors:  Courtney M Starks; Russell B Williams; Stephanie M Rice; Vanessa L Norman; Julie A Lawrence; Matt G Goering; Mark O'Neil-Johnson; Jin-Feng Hu; Gary R Eldridge
Journal:  Phytochemistry       Date:  2011-11-24       Impact factor: 4.072

2.  Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest.

Authors:  Brian T Murphy; Peggie Brodie; Carla Slebodnick; James S Miller; Chris Birkinshaw; Lucien M Randrianjanaka; Rabodo Andriantsiferana; Vincent E Rasamison; Karen TenDyke; Edward M Suh; David G I Kingston
Journal:  J Nat Prod       Date:  2008-01-05       Impact factor: 4.050

3.  Cell cycle arrest and apoptosis induction by methanolic leaves extracts of four Annonaceae plants.

Authors:  Kitti Pumiputavon; Tanawat Chaowasku; Chalermpong Saenjum; Maslin Osathanunkul; Boonsong Wungsintaweekul; Kriangkrai Chawansuntati; Jiraprapa Wipasa; Pathrapol Lithanatudom
Journal:  BMC Complement Altern Med       Date:  2017-06-05       Impact factor: 3.659

4.  Simultaneous HPTLC analysis and in vitro antileishmanic activity of various secondary metabolites in extract of the traditional medicinal herb Artabotrys hexapetalus (L.f.).

Authors:  Sakshi Bajaj; Sharad Ramesh Wakode; Washim Khan; Satish Manchanda; Sachin Kumar
Journal:  Ayu       Date:  2018 Apr-Jun

5.  The complete chloroplast genome sequence of Artabotrys pilosus (Annonaceae).

Authors:  Ze-Rui Liang; Jin-Man Lei; Hui Zhang; Yong-Quan Li; Bipei Zhang
Journal:  Mitochondrial DNA B Resour       Date:  2021-12-10       Impact factor: 0.658
  5 in total

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