| Literature DB >> 17988099 |
Sampada Karkare1, Eba Adou, Shugeng Cao, Peggy Brodie, James S Miller, N M Andrianjafy, J Razafitsalama, Rabodo Andriantsiferana, Vincent E Rasamison, David G I Kingston.
Abstract
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1-6, as well as the four known cardenolide glycosides digitoxigenin 3-O-[beta-D-glucopyrananosyl-(1-->4)-alpha-L-acofriopyranoside], corotoxigenin 3-O-beta-D-boivinoside, 17alpha-corotoxigenin 3-O-beta-D-sarmentoside, and uzarigenin 3-O-alpha-L-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC50 = 0.17 microM.Entities:
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Year: 2007 PMID： 17988099 PMCID： PMC2528960 DOI： 10.1021/np070336n
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050