Literature DB >> 1882841

Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.

R Dono1, N Montuori, M Rocchi, L De Ponti-Zilli, A Ciccodicola, M G Persico.   

Abstract

We have previously reported on the identification of a cDNA clone encoding a novel human growth factor, named "CRIPTO," that is abundantly expressed in undifferentiated human NTERA-2 clone D1 (NT2/D1) and mouse (F9) teratocarcinoma cells. We now report the organization and nucleotide sequence of two related genomic sequences. One (CR-1) corresponds to the structural gene encoding the human CRIPTO protein expressed in the undifferentiated human teratocarcinoma cells, and the other (CR-3) corresponds to a complete copy of the mRNA containing seven base substitutions in the coding region representing both silent and replacement substitutions. The 440 bp 5' to the CAP site of CR-1 are preserved in CR-3. CR-1 maps to chromosome 3, and CR-3 maps to Xq21-q22. Southern blot analysis reveals that multiple CRIPTO-related DNA sequences are present in the human as well as in the mouse genome.

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Year:  1991        PMID： 1882841      PMCID： PMC1683146     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  33 in total

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Authors:  W D Benton; R W Davis
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Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

5.  Human transforming growth factor-alpha: precursor structure and expression in E. coli.

Authors:  R Derynck; A B Roberts; M E Winkler; E Y Chen; D V Goeddel
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

6.  S1-hypersensitive sites in eukaryotic promoter regions.

Authors:  T Evans; E Schon; G Gora-Maslak; J Patterson; A Efstratiadis
Journal:  Nucleic Acids Res       Date:  1984-11-12       Impact factor: 16.971

7.  The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

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Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

8.  Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

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Journal:  Nucleic Acids Res       Date:  1986-10-24       Impact factor: 16.971

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Authors:  J R McCarrey; K Thomas
Journal:  Nature       Date:  1987 Apr 2-8       Impact factor: 49.962

Review 10.  Growth factor superfamilies and mammalian embryogenesis.

Authors:  M Mercola; C D Stiles
Journal:  Development       Date:  1988-03       Impact factor: 6.868
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  10 in total

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3.  Characterization of the mouse Tdgf1 gene and Tdgf pseudogenes.

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Journal:  Mamm Genome       Date:  1996-05       Impact factor: 2.957

4.  Cripto-1 expression and its prognostic value in human bladder cancer patients.

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5.  Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease.

Authors:  R J Alexander; A Panja; E Kaplan-Liss; L Mayer; R F Raicht
Journal:  Dig Dis Sci       Date:  1995-03       Impact factor: 3.199

Review 6.  Epidermal growth factor-related peptides in the pathogenesis of human breast cancer.

Authors:  N Normanno; F Ciardiello; R Brandt; D S Salomon
Journal:  Breast Cancer Res Treat       Date:  1994-01       Impact factor: 4.872

7.  Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21.

Authors:  S Saccone; A Rapisarda; S Motta; R Dono; G M Persico; G Della Valle
Journal:  Hum Genet       Date:  1995-02       Impact factor: 4.132

8.  Geometry of the Gene Expression Space of Individual Cells.

Authors:  Yael Korem; Pablo Szekely; Yuval Hart; Hila Sheftel; Jean Hausser; Avi Mayo; Michael E Rothenberg; Tomer Kalisky; Uri Alon
Journal:  PLoS Comput Biol       Date:  2015-07-10       Impact factor: 4.475

9.  A Novel Localization in Human Large Extracellular Vesicles for the EGF-CFC Founder Member CRIPTO and Its Biological and Therapeutic Implications.

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Journal:  Cancers (Basel)       Date:  2022-07-29       Impact factor: 6.575

10.  Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas.

Authors:  C F Qi; D S Liscia; N Normanno; G Merlo; G R Johnson; W J Gullick; F Ciardiello; T Saeki; R Brandt; N Kim
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  10 in total

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