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Literature DB >> 7860072

Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21.

S Saccone¹, A Rapisarda, S Motta, R Dono, G M Persico, G Della Valle.

Abstract

The CRIPTO gene encodes a novel human growth factor structurally related to epidermal growth factor. We localized the CRIPTO gene to chromosome 3p21 by fluorescence in situ hybridization with a cosmid clone containing 40 kb of the CRIPTO genomic region (TDGF-1). To suppress hybridization to CRIPTO-related sequences, present in multiple copies in the human genome, hybridization was carried out in the presence of unlabeled CRIPTO cDNA in excess over the probe. Our finding confirms the provisional mapping of the CRIPTO gene to chromosome 3, and assigns it precisely to a chromosomal region involved in several rearrangements occurring in malignancy.

Entities: Disease Gene Species

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Year: 1995 PMID： 7860072 DOI： 10.1007/bf00209409

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

7 in total

1. A high resolution in situ hybridization technique for the direct visualization of labeled G-banded early metaphase and prophase chromosomes.

Authors: M E Chandler; J J Yunis
Journal: Cytogenet Cell Genet Date: 1978

2. Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

Authors: F Ciardiello; N Kim; T Saeki; R Dono; M G Persico; G D Plowman; J Garrigues; S Radke; G J Todaro; D S Salomon
Journal: Proc Natl Acad Sci U S A Date: 1991-09-01 Impact factor: 11.205

3. Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line.

Authors: F Ciardiello; R Dono; N Kim; M G Persico; D S Salomon
Journal: Cancer Res Date: 1991-02-01 Impact factor: 12.701

4. Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides.

Authors: F Ciardiello; G Tortora; C Bianco; M P Selvam; F Basolo; G Fontanini; F Pacifico; N Normanno; R Brandt; M G Persico
Journal: Oncogene Date: 1994-01 Impact factor: 9.867

5. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.

Authors: R Dono; N Montuori; M Rocchi; L De Ponti-Zilli; A Ciccodicola; M G Persico
Journal: Am J Hum Genet Date: 1991-09 Impact factor: 11.025

6. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization.

Authors: S Saccone; G Biamonti; S Maugeri; M T Bassi; G Bunone; S Riva; G Della Valle
Journal: Genomics Date: 1992-01 Impact factor: 5.736

7. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.

Authors: A Ciccodicola; R Dono; S Obici; A Simeone; M Zollo; M G Persico
Journal: EMBO J Date: 1989-07 Impact factor: 11.598

7 in total

4 in total

Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21.

1. A high resolution in situ hybridization technique for the direct visualization of labeled G-banded early metaphase and prophase chromosomes.

2. Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

3. Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line.

4. Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides.

5. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence.

6. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization.

7. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.

1. Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes.

2. Characterization of the mouse Tdgf1 gene and Tdgf pseudogenes.

3. Role of Oncofetal Protein CR-1 as a Potential Tumor Marker for Oral Squamous Cell Carcinoma.

4. Cripto haploinsufficiency affects in vivo colon tumor development.