Literature DB >> 18810304

Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample.

Kerstin U Ludwig1, Darina Roeske, Johannes Schumacher, Gerd Schulte-Körne, Inke R König, Andreas Warnke, Ellen Plume, Andreas Ziegler, Helmut Remschmidt, Bertram Müller-Myhsok, Markus M Nöthen, Per Hoffmann.   

Abstract

The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.

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Year:  2008        PMID： 18810304     DOI： 10.1007/s00702-008-0124-6

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  15 in total

1.  Foundation literacy acquisition in European orthographies.

Authors:  Philip H K Seymour; Mikko Aro; Jane M Erskine
Journal:  Br J Psychol       Date:  2003-05

2.  Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses.

Authors:  Karen E Deffenbacher; Judith B Kenyon; Denise M Hoover; Richard K Olson; Bruce F Pennington; John C DeFries; Shelley D Smith
Journal:  Hum Genet       Date:  2004-05-11       Impact factor: 4.132

3.  DCDC2 is associated with reading disability and modulates neuronal development in the brain.

Authors:  Haiying Meng; Shelley D Smith; Karl Hager; Matthew Held; Jonathan Liu; Richard K Olson; Bruce F Pennington; John C DeFries; Joel Gelernter; Thomas O'Reilly-Pol; Stefan Somlo; Pawel Skudlarski; Sally E Shaywitz; Bennett A Shaywitz; Karen Marchione; Yu Wang; Murugan Paramasivam; Joseph J LoTurco; Grier P Page; Jeffrey R Gruen
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-08       Impact factor: 11.205

4.  Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.

Authors:  Johannes Schumacher; Heidi Anthoni; Faten Dahdouh; Inke R König; Axel M Hillmer; Nadine Kluck; Malou Manthey; Ellen Plume; Andreas Warnke; Helmut Remschmidt; Jutta Hülsmann; Sven Cichon; Cecilia M Lindgren; Peter Propping; Marco Zucchelli; Andreas Ziegler; Myriam Peyrard-Janvid; Gerd Schulte-Körne; Markus M Nöthen; Juha Kere
Journal:  Am J Hum Genet       Date:  2005-11-17       Impact factor: 11.025

5.  Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.

Authors:  Natalie Cope; Denise Harold; Gary Hill; Valentina Moskvina; Jim Stevenson; Peter Holmans; Michael J Owen; Michael C O'Donovan; Julie Williams
Journal:  Am J Hum Genet       Date:  2005-02-16       Impact factor: 11.025

6.  Persistence of dyslexia: the Connecticut Longitudinal Study at adolescence.

Authors:  S E Shaywitz; J M Fletcher; J M Holahan; A E Shneider; K E Marchione; K K Stuebing; D J Francis; K R Pugh; B A Shaywitz
Journal:  Pediatrics       Date:  1999-12       Impact factor: 7.124

Review 7.  Breakthroughs in the search for dyslexia candidate genes.

Authors:  Lauren M McGrath; Shelley D Smith; Bruce F Pennington
Journal:  Trends Mol Med       Date:  2006-06-16       Impact factor: 11.951

8.  Interrelationship and familiality of dyslexia related quantitative measures.

Authors:  G Schulte-Körne; A Ziegler; W Deimel; J Schumacher; E Plume; C Bachmann; A Kleensang; P Propping; M M Nöthen; A Warnke; H Remschmidt; I R König
Journal:  Ann Hum Genet       Date:  2006-10-13       Impact factor: 1.670

9.  Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.

Authors:  D Harold; S Paracchini; T Scerri; M Dennis; N Cope; G Hill; V Moskvina; J Walter; A J Richardson; M J Owen; J F Stein; E D Green; M C O'Donovan; J Williams; A P Monaco
Journal:  Mol Psychiatry       Date:  2006-10-10       Impact factor: 15.992

10.  The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.

Authors:  Silvia Paracchini; Ankur Thomas; Sandra Castro; Cecilia Lai; Murugan Paramasivam; Yu Wang; Brendan J Keating; Jennifer M Taylor; Douglas F Hacking; Thomas Scerri; Clyde Francks; Alex J Richardson; Richard Wade-Martins; John F Stein; Julian C Knight; Andrew J Copp; Joseph Loturco; Anthony P Monaco
Journal:  Hum Mol Genet       Date:  2006-04-06       Impact factor: 6.150
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  22 in total

1.  Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1.

Authors:  C E Szalkowski; J R Hinman; S W Threlkeld; Y Wang; A LePack; G D Rosen; J J Chrobak; J J LoTurco; R H Fitch
Journal:  Genes Brain Behav       Date:  2010-11-25       Impact factor: 3.449

2.  Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.

Authors:  Jessica Becker; Darina Czamara; Tom S Scerri; Franck Ramus; Valéria Csépe; Joel B Talcott; John Stein; Andrew Morris; Kerstin U Ludwig; Per Hoffmann; Ferenc Honbolygó; Dénes Tóth; Fabien Fauchereau; Caroline Bogliotti; Stéphanie Iannuzzi; Yves Chaix; Sylviane Valdois; Catherine Billard; Florence George; Isabelle Soares-Boucaud; Christophe-Loïc Gérard; Sanne van der Mark; Enrico Schulz; Anniek Vaessen; Urs Maurer; Kaisa Lohvansuu; Heikki Lyytinen; Marco Zucchelli; Daniel Brandeis; Leo Blomert; Paavo H T Leppänen; Jennifer Bruder; Anthony P Monaco; Bertram Müller-Myhsok; Juha Kere; Karin Landerl; Markus M Nöthen; Gerd Schulte-Körne; Silvia Paracchini; Myriam Peyrard-Janvid; Johannes Schumacher
Journal:  Eur J Hum Genet       Date:  2013-09-11       Impact factor: 4.246

3.  KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia.

Authors:  Sara Mascheretti; Valentina Riva; Roberto Giorda; Silvana Beri; Lara Francesca Emilia Lanzoni; Maria Rosaria Cellino; Cecilia Marino
Journal:  J Hum Genet       Date:  2014-01-16       Impact factor: 3.172

4.  Neuroimaging genetics studies of specific reading disability and developmental language disorder: A review.

Authors:  Nicole Landi; Meaghan Perdue
Journal:  Lang Linguist Compass       Date:  2019-09-05

5.  Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.

Authors:  Y Wang; X Yin; G Rosen; L Gabel; S M Guadiana; M R Sarkisian; A M Galaburda; J J Loturco
Journal:  Neuroscience       Date:  2011-06-13       Impact factor: 3.590

Review 6.  In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.

Authors:  Thomas Skiba; Nicole Landi; Richard Wagner; Elena L Grigorenko
Journal:  Behav Genet       Date:  2011-01-19       Impact factor: 2.805

7.  Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability.

Authors:  Natalie Cope; John D Eicher; Haiying Meng; Christopher J Gibson; Karl Hager; Cheryl Lacadie; Robert K Fulbright; R Todd Constable; Grier P Page; Jeffrey R Gruen
Journal:  Neuroimage       Date:  2012-06-27       Impact factor: 6.556

8.  Meta-analysis of the association between DCDC2 polymorphisms and risk of dyslexia.

Authors:  Rong Zhong; Beifang Yang; Hui Tang; Li Zou; Ranran Song; Ling-Qiang Zhu; Xiaoping Miao
Journal:  Mol Neurobiol       Date:  2012-12-11       Impact factor: 5.590

Review 9.  Genetics of developmental dyslexia.

Authors:  Thomas S Scerri; Gerd Schulte-Körne
Journal:  Eur Child Adolesc Psychiatry       Date:  2009-11-29       Impact factor: 4.785

10.  The role of DCDC2 genetic variants and low socioeconomic status in vulnerability to attention problems.

Authors:  Valentina Riva; Cecilia Marino; Roberto Giorda; Massimo Molteni; Maria Nobile
Journal:  Eur Child Adolesc Psychiatry       Date:  2014-07-11       Impact factor: 4.785
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