Literature DB >> 18804176

Macrolide myths.

Alexander S Mankin1.   

Abstract

In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'. This review focuses on certain aspects of binding and action of macrolides that may need re-evaluation in view of the new findings.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18804176      PMCID： PMC3874820          DOI： 10.1016/j.mib.2008.08.003

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  36 in total

Review 1.  Macrolide resistance conferred by base substitutions in 23S rRNA.

Authors:  B Vester; S Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

2.  Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria.

Authors:  F Schlünzen; R Zarivach; J Harms; A Bashan; A Tocilj; R Albrecht; A Yonath; F Franceschi
Journal:  Nature       Date:  2001-10-25       Impact factor: 49.962

Review 3.  The chemistry of protein synthesis and voyage through the ribosomal tunnel.

Authors:  Simon Jenni; Nenad Ban
Journal:  Curr Opin Struct Biol       Date:  2003-04       Impact factor: 6.809

4.  The structures of four macrolide antibiotics bound to the large ribosomal subunit.

Authors:  Jeffrey L Hansen; Joseph A Ippolito; Nenad Ban; Poul Nissen; Peter B Moore; Thomas A Steitz
Journal:  Mol Cell       Date:  2002-07       Impact factor: 17.970

5.  A plasmid-coded and site-directed mutation in Escherichia coli 23S RNA that confers resistance to erythromycin: implications for the mechanism of action of erythromycin.

Authors:  B Vester; R A Garrett
Journal:  Biochimie       Date:  1987-08       Impact factor: 4.079

6.  Structural basis for the antibiotic activity of ketolides and azalides.

Authors:  Frank Schlünzen; Jörg M Harms; Francois Franceschi; Harly A S Hansen; Heike Bartels; Raz Zarivach; Ada Yonath
Journal:  Structure       Date:  2003-03       Impact factor: 5.006

7.  Effects of macrolides on peptide-bond formation and translocation.

Authors:  J C Mao; E E Robishaw
Journal:  Biochemistry       Date:  1971-05-25       Impact factor: 3.162

8.  Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A.

Authors:  T Otaka; A Kaji
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

9.  Structural insight into the antibiotic action of telithromycin against resistant mutants.

Authors:  Rita Berisio; Joerg Harms; Frank Schluenzen; Raz Zarivach; Harly A S Hansen; Paola Fucini; Ada Yonath
Journal:  J Bacteriol       Date:  2003-07       Impact factor: 3.490

10.  The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome.

Authors:  Tanel Tenson; Martin Lovmar; Måns Ehrenberg
Journal:  J Mol Biol       Date:  2003-07-25       Impact factor: 5.469
View more
  36 in total

1.  Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.

Authors:  Samer S Daher; Xiao Jin; Jimmy Patel; Joel S Freundlich; Bettina Buttaro; Rodrigo B Andrade
Journal:  Bioorg Med Chem Lett       Date:  2019-03-26       Impact factor: 2.823

2.  Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

Authors:  Jack A Dunkle; Liqun Xiong; Alexander S Mankin; Jamie H D Cate
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

3.  Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin.

Authors:  Bharat Wagh; Tapas Paul; Ian Glassford; Charles Debrosse; Dorota Klepacki; Meagan C Small; Alexander D Mackerell; Rodrigo B Andrade
Journal:  ACS Med Chem Lett       Date:  2012-12-12       Impact factor: 4.345

4.  Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel.

Authors:  Arren Z Washington; Subhasish Tapadar; Alex George; Adegboyega K Oyelere
Journal:  Bioorg Med Chem       Date:  2015-05-06       Impact factor: 3.641

Review 5.  The macrolide antibiotic renaissance.

Authors:  George P Dinos
Journal:  Br J Pharmacol       Date:  2017-08-10       Impact factor: 8.739

6.  Clarithromycin Exerts an Antibiofilm Effect against Salmonella enterica Serovar Typhimurium rdar Biofilm Formation and Transforms the Physiology towards an Apparent Oxygen-Depleted Energy and Carbon Metabolism.

Authors:  Munirah Zafar; Humera Jahan; Sulman Shafeeq; Manfred Nimtz; Lothar Jänsch; Ute Römling; M Iqbal Choudhary
Journal:  Infect Immun       Date:  2020-10-19       Impact factor: 3.441

7.  The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates.

Authors:  Concha Nieto; Ewa Sadowy; Adela G de la Campa; Waleria Hryniewicz; Manuel Espinosa
Journal:  PLoS One       Date:  2010-06-23       Impact factor: 3.240

8.  Reliable semi-synthesis of hydrolysis-resistant 3'-peptidyl-tRNA conjugates containing genuine tRNA modifications.

Authors:  Dagmar Graber; Holger Moroder; Jessica Steger; Krista Trappl; Norbert Polacek; Ronald Micura
Journal:  Nucleic Acids Res       Date:  2010-06-04       Impact factor: 16.971

9.  Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia.

Authors:  Carla Maria P Ribeiro; Harry Hurd; Yichao Wu; Mary E B Martino; Lisa Jones; Brian Brighton; Richard C Boucher; Wanda K O'Neal
Journal:  PLoS One       Date:  2009-06-05       Impact factor: 3.240

10.  Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study.

Authors:  Gunter Assmann; Olaf Kueck; Timm Kirchhoff; Herbert Rosenthal; Jan Voswinkel; Michael Pfreundschuh; Henning Zeidler; Annette D Wagner
Journal:  Arthritis Res Ther       Date:  2009-10-09       Impact factor: 5.156
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.