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Literature DB >> 12837804

Structural insight into the antibiotic action of telithromycin against resistant mutants.

Rita Berisio¹, Joerg Harms, Frank Schluenzen, Raz Zarivach, Harly A S Hansen, Paola Fucini, Ada Yonath.

Abstract

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

Entities: Chemical Species

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Year: 2003 PMID： 12837804 PMCID： PMC164882 DOI： 10.1128/JB.185.14.4276-4279.2003

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

19 in total

1. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria.

Authors: F Schlünzen; R Zarivach; J Harms; A Bashan; A Tocilj; R Albrecht; A Yonath; F Franceschi
Journal: Nature Date: 2001-10-25 Impact factor: 49.962

2. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium.

Authors: J Harms; F Schluenzen; R Zarivach; A Bashan; S Gat; I Agmon; H Bartels; F Franceschi; A Yonath
Journal: Cell Date: 2001-11-30 Impact factor: 41.582

3. Structural basis for the antibiotic activity of ketolides and azalides.

Authors: Frank Schlünzen; Jörg M Harms; Francois Franceschi; Harly A S Hansen; Heike Bartels; Raz Zarivach; Ada Yonath
Journal: Structure Date: 2003-03 Impact factor: 5.006

4. Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Authors: L Xiong; P Kloss; S Douthwaite; N M Andersen; S Swaney; D L Shinabarger; A S Mankin
Journal: J Bacteriol Date: 2000-10 Impact factor: 3.490

5. Structural insight into the role of the ribosomal tunnel in cellular regulation.

Authors: Rita Berisio; Frank Schluenzen; Joerg Harms; Anat Bashan; Tamar Auerbach; David Baram; Ada Yonath
Journal: Nat Struct Biol Date: 2003-05

6. Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

Authors: Mingfu Liu; Stephen Douthwaite
Journal: Antimicrob Agents Chemother Date: 2002-06 Impact factor: 5.191

7. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA.

Authors: S Douthwaite; L H Hansen; P Mauvais
Journal: Mol Microbiol Date: 2000-04 Impact factor: 3.501

Review 8. Telithromycin: the first of the ketolides.

Authors: Christopher S Shain; Guy W Amsden
Journal: Ann Pharmacother Date: 2002-03 Impact factor: 3.154

9. A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.

Authors: L Xiong; S Shah; P Mauvais; A S Mankin
Journal: Mol Microbiol Date: 1999-01 Impact factor: 3.501

10. In vivo efficacy of telithromycin (HMR3647) against Streptococcus pneumoniae and Haemophilus influenzae.

Authors: H Okamoto; S Miyazaki; K Tateda; Y Ishii; K Yamaguchi
Journal: Antimicrob Agents Chemother Date: 2001-11 Impact factor: 5.191

44 in total

1. Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides.

Authors: O Y Misyurina; E V Chipitsyna; Y P Finashutina; V N Lazarev; T A Akopian; A M Savicheva; V M Govorun
Journal: Antimicrob Agents Chemother Date: 2004-04 Impact factor: 5.191

2. Molecular mechanisms by which rRNA mutations confer resistance to clindamycin.

Authors: Jacob Poehlsgaard; Peter Pfister; Erik C Böttger; Stephen Douthwaite
Journal: Antimicrob Agents Chemother Date: 2005-04 Impact factor: 5.191

3. In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides.

Authors: Darren Abbanat; Glenda Webb; Barbara Foleno; Y Li; Mark Macielag; Deborah Montenegro; Ellyn Wira; Karen Bush
Journal: Antimicrob Agents Chemother Date: 2005-01 Impact factor: 5.191

4. Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects.

Authors: J Gordon Still; Jennifer Schranz; Thorsten P Degenhardt; Drusilla Scott; Prabhavathi Fernandes; Maria J Gutierrez; Kay Clark
Journal: Antimicrob Agents Chemother Date: 2011-01-31 Impact factor: 5.191

5. Binding site of the bridged macrolides in the Escherichia coli ribosome.

Authors: Liqun Xiong; Yakov Korkhin; Alexander S Mankin
Journal: Antimicrob Agents Chemother Date: 2005-01 Impact factor: 5.191

6. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

Authors: Jack A Dunkle; Liqun Xiong; Alexander S Mankin; Jamie H D Cate
Journal: Proc Natl Acad Sci U S A Date: 2010-09-27 Impact factor: 11.205

10. The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.

Authors: Renaud Chollet; Jacqueline Chevalier; André Bryskier; Jean-Marie Pagès
Journal: Antimicrob Agents Chemother Date: 2004-09 Impact factor: 5.191