Literature DB >> 30962084

Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.

Samer S Daher1, Xiao Jin1, Jimmy Patel2, Joel S Freundlich2, Bettina Buttaro3, Rodrigo B Andrade4.   

Abstract

Novel antibacterial drugs that treat multidrug resistant pathogens are in high demand. We have synthesized analogs of solithromycin using Cu(I)-mediated click chemistry. Evaluation of the analogs using Minimum Inhibitory Concentration (MIC) assays against resistant Staphylococcus aureus, Escherichia coli, and multidrug resistant pathogens Enterococcus faecium and Acinetobacter baumannii showed they possess potencies similar to those of solithromycin, thus demonstrating their potential as future therapeutics to combat the existential threat of multidrug resistant pathogens.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antibiotic; Click chemistry; Multidrug resistance; Solithromycin

Year:  2019        PMID： 30962084      PMCID： PMC6487207          DOI： 10.1016/j.bmcl.2019.03.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

1.  Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.

Authors:  Z Ma; R F Clark; A Brazzale; S Wang; M J Rupp; L Li; G Griesgraber; S Zhang; H Yong; L T Phan; P A Nemoto; D T Chu; J J Plattner; X Zhang; P Zhong; Z Cao; A M Nilius; V D Shortridge; R Flamm; M Mitten; J Meulbroek; P Ewing; J Alder; Y S Or
Journal:  J Med Chem       Date:  2001-11-22       Impact factor: 7.446

2.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Authors:  Hartmuth C. Kolb; M. G. Finn; K. Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2001-06-01       Impact factor: 15.336

3.  Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides.

Authors:  Anne-Laure Prunier; Brigitte Malbruny; Didier Tandé; Bertrand Picard; Roland Leclercq
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

4.  A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.

Authors:  Vsevolod V Rostovtsev; Luke G Green; Valery V Fokin; K Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2002-07-15       Impact factor: 15.336

5.  A novel chromatography system to isolate active ribosomes from pathogenic bacteria.

Authors:  Bruce A Maguire; Lillian M Wondrack; Leonard G Contillo; Zuoyu Xu
Journal:  RNA       Date:  2007-11-12       Impact factor: 4.942

6.  Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens.

Authors:  A Denis; C Agouridas; J M Auger; Y Benedetti; A Bonnefoy; F Bretin; J F Chantot; A Dussarat; C Fromentin; S G D'Ambrières; S Lachaud; P Laurin; O Le Martret; V Loyau; N Tessot; J M Pejac; S Perron
Journal:  Bioorg Med Chem Lett       Date:  1999-11-01       Impact factor: 2.823

7.  Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.

Authors:  Christian W Tornøe; Caspar Christensen; Morten Meldal
Journal:  J Org Chem       Date:  2002-05-03       Impact factor: 4.354

Review 8.  Acinetobacter baumannii: emergence of a successful pathogen.

Authors:  Anton Y Peleg; Harald Seifert; David L Paterson
Journal:  Clin Microbiol Rev       Date:  2008-07       Impact factor: 26.132

Review 9.  Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options.

Authors:  Lisa L Maragakis; Trish M Perl
Journal:  Clin Infect Dis       Date:  2008-04-15       Impact factor: 9.079

10.  Prevalence and mechanism of resistance against macrolides, lincosamides, and streptogramins among Enterococcus faecium isolates from food-producing animals and hospital patients in Belgium.

Authors:  E M De Graef; A Decostere; E De Leener; H Goossens; M Baele; F Haesebrouck
Journal:  Microb Drug Resist       Date:  2007       Impact factor: 3.431
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  4 in total

1.  Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin.

Authors:  Samer S Daher; Miseon Lee; Xiao Jin; Christiana N Teijaro; Pamela R Barnett; Joel S Freundlich; Rodrigo B Andrade
Journal:  Eur J Med Chem       Date:  2022-02-24       Impact factor: 6.514

2.  Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.

Authors:  Jonathan H Boyce; Bobo Dang; Beatrice Ary; Quinn Edmondson; Charles S Craik; William F DeGrado; Ian B Seiple
Journal:  J Am Chem Soc       Date:  2020-12-10       Impact factor: 15.419

3.  Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin.

Authors:  Samer S Daher; Miseon Lee; Xiao Jin; Christiana N Teijaro; Steven E Wheeler; Marlene A Jacobson; Bettina Buttaro; Rodrigo B Andrade
Journal:  ChemMedChem       Date:  2021-09-03       Impact factor: 3.466

Review 4.  Scaffold Modifications in Erythromycin Macrolide Antibiotics. A Chemical Minireview.

Authors:  Kjell Undheim
Journal:  Molecules       Date:  2020-08-28       Impact factor: 4.411
  4 in total

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