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Literature DB >> 1101261

Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A.

Abstract

Erythromycin A released peptidyl-tRNA in the in vitro polypeptide synthesis system with bacterial components programmed by synthetic polynucleotide. This is consistent with our hypothesis that erythromycin A inhibits translocation by preventing proper situation of oligopeptidyl-tRNA in the donor (D) site on ribosomes.

Entities: Chemical Species

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Year: 1975 PMID： 1101261 PMCID： PMC432827 DOI： 10.1073/pnas.72.7.2649

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. The action of trypsin on polylysine.

Authors: S G WALEY; J WATSON
Journal: Biochem J Date: 1953-09 Impact factor: 3.857

2. Selective action of erythromycin on initiating ribosomes.

Authors: P C Tai; B J Wallace; B D Davis
Journal: Biochemistry Date: 1974-10-22 Impact factor: 3.162

3. Evidence that fusidic acid inhibits the binding of aminoacyl-tRNA to the donor as well as the acceptor site of the ribosomes.

Authors: T Otaka; A Kaji
Journal: Eur J Biochem Date: 1973-09-21

4. Erythromycin, a peptidyltransferase effector.

Authors: J C Mao; E E Robishaw
Journal: Biochemistry Date: 1972-12-05 Impact factor: 3.162

5. Factor-dependent release of ribosomes from messenger RNA. Requirement for two heat-stable factors.

Authors: A Hirashima; A Kaji
Journal: J Mol Biol Date: 1972-03-14 Impact factor: 5.469

6. Studies on polynucleotides. LXXXVI. Enzymic hydrolysis of N-acylaminoacyl-transfer RNA.

Authors: H Kössel; U L RajBhandary
Journal: J Mol Biol Date: 1968-08-14 Impact factor: 5.469

7. Enzymatic hydrolysis of peptidyl-tRNA.

Authors: N de Groot; A Panet; Y Lapidot
Journal: Biochem Biophys Res Commun Date: 1968-04-05 Impact factor: 3.575

8. Enzymatic hydrolysis of N-substituted aminoacyl-tRNA.

Authors: F Cuzin; N Kretchmer; R E Greenberg; R Hurwitz; F Chapeville
Journal: Proc Natl Acad Sci U S A Date: 1967-11 Impact factor: 11.205

9. Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits.

Authors: K Tanaka; H Teraoka; M Tamaki
Journal: FEBS Lett Date: 1971-02-12 Impact factor: 4.124

10. Breakdown by streptomycin of initiation complexes formed on ribosomes of Escherichia coli.

Authors: J Modolell; B D Davis
Journal: Proc Natl Acad Sci U S A Date: 1970-11 Impact factor: 11.205

14 in total

Review 1. Macrolide myths.

Authors: Alexander S Mankin
Journal: Curr Opin Microbiol Date: 2008-10-03 Impact factor: 7.934

Review 2. The macrolide antibiotic renaissance.

Authors: George P Dinos
Journal: Br J Pharmacol Date: 2017-08-10 Impact factor: 8.739

3. Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria.

Authors: P M McNicholas; D J Najarian; P A Mann; D Hesk; R S Hare; K J Shaw; T A Black
Journal: Antimicrob Agents Chemother Date: 2000-05 Impact factor: 5.191

4. The general mode of translation inhibition by macrolide antibiotics.

Authors: Krishna Kannan; Pinal Kanabar; David Schryer; Tanja Florin; Eugene Oh; Neil Bahroos; Tanel Tenson; Jonathan S Weissman; Alexander S Mankin
Journal: Proc Natl Acad Sci U S A Date: 2014-10-27 Impact factor: 11.205

5. Accumulation of peptidyl tRNA is lethal to Escherichia coli.

Authors: J R Menninger
Journal: J Bacteriol Date: 1979-01 Impact factor: 3.490

Review 6. How Macrolide Antibiotics Work.

Authors: Nora Vázquez-Laslop; Alexander S Mankin
Journal: Trends Biochem Sci Date: 2018-07-24 Impact factor: 13.807

10. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes.

Authors: J R Menninger; D P Otto
Journal: Antimicrob Agents Chemother Date: 1982-05 Impact factor: 5.191