Literature DB >> 18626507

Impact of nerve sparing on surgical margins and biochemical recurrence: results from the SEARCH database.

J L Nelles1, S J Freedland, J C Presti, M K Terris, W J Aronson, C L Amling, C J Kane.   

Abstract

The effects of nerve sparing on the risk of positive surgical margins (PSMs) and biochemical recurrence after radical prostatectomy (RP) remain controversial. We examined data from 1018 men treated by RP between 1988 and 2006 at five centers in the Shared Equal Access Regional Cancer Hospital database. Neither bilateral nor unilateral nerve-sparing techniques were associated with a higher risk of PSM; on multivariate analysis of individual sides, the risk of PSM on either side was not increased by nerve sparing on either side. The risk for biochemical recurrence was not affected by bilateral or unilateral nerve sparing. When used on appropriately selected patients, nerve sparing does not increase the probability of PSM or biochemical recurrence after RP.

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Year:  2008        PMID： 18626507      PMCID： PMC3174863          DOI： 10.1038/pcan.2008.40

Source DB:  PubMed          Journal:  Prostate Cancer Prostatic Dis        ISSN： 1365-7852            Impact factor:   5.554


  17 in total

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Authors:  Stephen J Freedland; Christopher L Amling; Frederick Dorey; Christopher J Kane; Joseph C Presti; Martha K Terris; William J Aronson
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Authors:  Stephen J Freedland; WilliamJ Aronson; Joseph C Presti; Christopher J Kane; Martha K Terris; David Elashoff; Christopher L Amling
Journal:  J Urol       Date:  2003-06       Impact factor: 7.450

9.  Can prostate biopsies predict suitability for nerve-sparing radical prostatectomy?

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7.  Preoperative factors predictive of posterolateral extracapsular extension after radical prostatectomy.

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8.  Degree of Preservation of Neurovascular Bundles in Radical Prostatectomy and Recurrence of Prostate Cancer.

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  8 in total

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