Literature DB >> 18559651

The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.

Fatima Bousejra-El Garah1, Catherine Claparols, Françoise Benoit-Vical, Bernard Meunier, Anne Robert.   

Abstract

The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.

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Year:  2008        PMID： 18559651      PMCID： PMC2493093          DOI： 10.1128/AAC.00165-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

Review 1.  A medicinal chemistry perspective on artemisinin and related endoperoxides.

Authors:  Paul M O'Neill; Gary H Posner
Journal:  J Med Chem       Date:  2004-06-03       Impact factor: 7.446

2.  The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity.

Authors:  W Peters
Journal:  Ann Trop Med Parasitol       Date:  1975-06

3.  Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.

Authors:  G H Posner; C H Oh; D Wang; L Gerena; W K Milhous; S R Meshnick; W Asawamahasadka
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

Review 4.  Epidemiology of drug-resistant malaria.

Authors:  Chansuda Wongsrichanalai; Amy L Pickard; Walther H Wernsdorfer; Steven R Meshnick
Journal:  Lancet Infect Dis       Date:  2002-04       Impact factor: 25.071

5.  The interaction of artemisinin with malarial hemozoin.

Authors:  Y L Hong; Y Z Yang; S R Meshnick
Journal:  Mol Biochem Parasitol       Date:  1994-01       Impact factor: 1.759

6.  Synthesis and antimalarial activity of trioxaquine derivatives.

Authors:  Odile Dechy-Cabaret; Françoise Benoit-Vical; Christophe Loup; Anne Robert; Heinz Gornitzka; Anne Bonhoure; Henri Vial; Jean-François Magnaval; Jean-Paul Séguéla; Bernard Meunier
Journal:  Chemistry       Date:  2004-04-02       Impact factor: 5.236

Review 7.  Qinghaosu (artemisinin): the price of success.

Authors:  N J White
Journal:  Science       Date:  2008-04-18       Impact factor: 47.728

Review 8.  Synthetic peroxides as antimalarials.

Authors:  Yuanqing Tang; Yuxiang Dong; Jonathan L Vennerstrom
Journal:  Med Res Rev       Date:  2004-07       Impact factor: 12.944

9.  A nuclear magnetic resonance study of the interactions of antimalarial drugs with porphyrins.

Authors:  S Moreau; B Perly; C Chachaty; C Deleuze
Journal:  Biochim Biophys Acta       Date:  1985-05-29

10.  Reaction of antimalarial endoperoxides with specific parasite proteins.

Authors:  W Asawamahasakda; I Ittarat; Y M Pu; H Ziffer; S R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191
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  11 in total

Review 1.  Malaria medicines: a glass half full?

Authors:  Timothy N C Wells; Rob Hooft van Huijsduijnen; Wesley C Van Voorhis
Journal:  Nat Rev Drug Discov       Date:  2015-05-22       Impact factor: 84.694

Review 2.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

Review 3.  Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Authors:  Drishti Agarwal; Rinkoo D Gupta; Satish K Awasthi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

4.  Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.

Authors:  Sumit S Mahajan; Jiri Gut; Philip J Rosenthal; Adam R Renslo
Journal:  Future Med Chem       Date:  2012-12       Impact factor: 3.808

5.  Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.

Authors:  Vincent Pradines; Julien Portela; Jérôme Boissier; Frédéric Coslédan; Bernard Meunier; Anne Robert
Journal:  Antimicrob Agents Chemother       Date:  2011-02-07       Impact factor: 5.191

6.  Selection of a trioxaquine as an antimalarial drug candidate.

Authors:  Frédéric Coslédan; Laurent Fraisse; Alain Pellet; François Guillou; Benjamin Mordmüller; Peter G Kremsner; Alicia Moreno; Dominique Mazier; Jean-Pierre Maffrand; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-05       Impact factor: 11.205

7.  Alkylating ability of artemisinin after Cu(I)-induced activation.

Authors:  Fatima Bousejra-El Garah; Marguerite Pitié; Laure Vendier; Bernard Meunier; Anne Robert
Journal:  J Biol Inorg Chem       Date:  2009-02-07       Impact factor: 3.358

8.  Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

Authors:  Julien Portela; Jérôme Boissier; Benjamin Gourbal; Vincent Pradines; Vincent Collière; Frédéric Coslédan; Bernard Meunier; Anne Robert
Journal:  PLoS Negl Trop Dis       Date:  2012-02-14

Review 9.  Quinoline-Based Hybrid Compounds with Antimalarial Activity.

Authors:  Xhamla Nqoro; Naki Tobeka; Blessing A Aderibigbe
Journal:  Molecules       Date:  2017-12-19       Impact factor: 4.411

Review 10.  The molecular mechanism of action of artemisinin--the debate continues.

Authors:  Paul M O'Neill; Victoria E Barton; Stephen A Ward
Journal:  Molecules       Date:  2010-03-12       Impact factor: 4.411
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