Literature DB >> 21300841

Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.

Vincent Pradines1, Julien Portela, Jérôme Boissier, Frédéric Coslédan, Bernard Meunier, Anne Robert.   

Abstract

Trioxaquine PA1259 is an efficient drug on larval- and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21300841      PMCID： PMC3088258          DOI： 10.1128/AAC.00082-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Schistosomiasis--a century searching for chemotherapeutic drugs.

Authors:  Gabriela Ribeiro-dos-Santos; Sergio Verjovski-Almeida; Luciana C C Leite
Journal:  Parasitol Res       Date:  2006-04-25       Impact factor: 2.289

2.  The antimalarial drug artemisinin alkylates heme in infected mice.

Authors:  Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-09       Impact factor: 11.205

Review 3.  Resistance of Schistosoma mansoni to praziquantel: is there a problem?

Authors:  Michael J Doenhoff; John R Kusel; Gerald C Coles; Donato Cioli
Journal:  Trans R Soc Trop Med Hyg       Date:  2002 Sep-Oct       Impact factor: 2.184

4.  Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.

Authors:  Françoise Benoit-Vical; Joël Lelièvre; Antoine Berry; Caroline Deymier; Odile Dechy-Cabaret; Jérôme Cazelles; Christophe Loup; Anne Robert; Jean-François Magnaval; Bernard Meunier
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

Review 5.  Human schistosomiasis.

Authors:  Bruno Gryseels; Katja Polman; Jan Clerinx; Luc Kestens
Journal:  Lancet       Date:  2006-09-23       Impact factor: 79.321

6.  Experimental observations on the sex ratio of adult Schistosoma mansoni, with comments on the natural male bias.

Authors:  J Boissier; H Moné
Journal:  Parasitology       Date:  2000-10       Impact factor: 3.234

Review 7.  Heme as trigger and target for trioxane-containing antimalarial drugs.

Authors:  Bernard Meunier; Anne Robert
Journal:  Acc Chem Res       Date:  2010-08-30       Impact factor: 22.384

Review 8.  Current status of vaccines for schistosomiasis.

Authors:  Donald P McManus; Alex Loukas
Journal:  Clin Microbiol Rev       Date:  2008-01       Impact factor: 26.132

Review 9.  Hybrid molecules with a dual mode of action: dream or reality?

Authors:  Bernard Meunier
Journal:  Acc Chem Res       Date:  2007-08-01       Impact factor: 22.384

10.  Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni.

Authors:  Sandra D Melman; Michelle L Steinauer; Charles Cunningham; Laura S Kubatko; Ibrahim N Mwangi; Nirvana Barker Wynn; Martin W Mutuku; Diana M S Karanja; Daniel G Colley; Carla L Black; William Evan Secor; Gerald M Mkoji; Eric S Loker
Journal:  PLoS Negl Trop Dis       Date:  2009-08-18
View more
  9 in total

1.  In vivo activity of aryl ozonides against Schistosoma species.

Authors:  Jennifer Keiser; Katrin Ingram; Mireille Vargas; Jacques Chollet; Xiaofang Wang; Yuxiang Dong; Jonathan L Vennerstrom
Journal:  Antimicrob Agents Chemother       Date:  2011-11-21       Impact factor: 5.191

2.  Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.

Authors:  Sumit S Mahajan; Jiri Gut; Philip J Rosenthal; Adam R Renslo
Journal:  Future Med Chem       Date:  2012-12       Impact factor: 3.808

Review 3.  Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

Authors:  Godwin Akpeko Dziwornu; Henrietta Dede Attram; Samuel Gachuhi; Kelly Chibale
Journal:  RSC Med Chem       Date:  2020-04-06

4.  Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.

Authors:  Steven W M Crossley; Carla Obradors; Ruben M Martinez; Ryan A Shenvi
Journal:  Chem Rev       Date:  2016-07-27       Impact factor: 60.622

5.  Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

Authors:  Julien Portela; Jérôme Boissier; Benjamin Gourbal; Vincent Pradines; Vincent Collière; Frédéric Coslédan; Bernard Meunier; Anne Robert
Journal:  PLoS Negl Trop Dis       Date:  2012-02-14

Review 6.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

Authors:  Alexander O Terent'ev; Dmitry A Borisov; Vera A Vil'; Valery M Dembitsky
Journal:  Beilstein J Org Chem       Date:  2014-01-08       Impact factor: 2.883

Review 7.  Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Authors:  Robert Bergquist; Jürg Utzinger; Jennifer Keiser
Journal:  Infect Dis Poverty       Date:  2017-03-28       Impact factor: 4.520

8.  In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum.

Authors:  Xiaoli Wang; Dan Yu; Chunxiang Li; Tingzheng Zhan; Tingting Zhang; Huihui Ma; Jing Xu; Chaoming Xia
Journal:  Parasit Vectors       Date:  2019-05-03       Impact factor: 3.876

9.  Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites.

Authors:  Thibaud Reyser; Tung H To; Chinedu Egwu; Lucie Paloque; Michel Nguyen; Alexandre Hamouy; Jean-Luc Stigliani; Christian Bijani; Jean-Michel Augereau; Jean-Patrick Joly; Julien Portela; Jeffrey Havot; Sylvain R A Marque; Jérôme Boissier; Anne Robert; Françoise Benoit-Vical; Gérard Audran
Journal:  Molecules       Date:  2020-08-24       Impact factor: 4.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.