Literature DB >> 19198896

Alkylating ability of artemisinin after Cu(I)-induced activation.

Fatima Bousejra-El Garah1, Marguerite Pitié, Laure Vendier, Bernard Meunier, Anne Robert.   

Abstract

The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin-copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.

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Year:  2009        PMID： 19198896     DOI： 10.1007/s00775-009-0474-z

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  31 in total

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Authors:  Paul M O'Neill; Gary H Posner
Journal:  J Med Chem       Date:  2004-06-03       Impact factor: 7.446

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Authors:  Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard Meunier
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3.  Interaction of Qinghaosu (Artemisinin) with Cysteine Sulfhydryl Mediated by Traces of Non-Heme Iron.

Authors: 
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Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

Review 5.  Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action.

Authors:  J N Cumming; P Ploypradith; G H Posner
Journal:  Adv Pharmacol       Date:  1997

6.  Preparation of the New Bis(phenanthroline) Ligand "Clip-Phen" and Evaluation of the Nuclease Activity of the Corresponding Copper Complex.

Authors:  Marguerite Pitié; Bruno Donnadieu; Bernard Meunier
Journal:  Inorg Chem       Date:  1998-07-13       Impact factor: 5.165

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Journal:  Nature       Date:  2004-08-19       Impact factor: 49.962

9.  The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin.

Authors:  J Bhisutthibhan; X Q Pan; P A Hossler; D J Walker; C A Yowell; J Carlton; J B Dame; S R Meshnick
Journal:  J Biol Chem       Date:  1998-06-26       Impact factor: 5.157

Review 10.  Qinghaosu (artemisinin): an antimalarial drug from China.

Authors:  D L Klayman
Journal:  Science       Date:  1985-05-31       Impact factor: 47.728
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  3 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

2.  Artemisinin displays bactericidal activity via copper-mediated DNA damage.

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Journal:  Virulence       Date:  2022-12       Impact factor: 5.882

3.  Synthesis of Mono- and Bisperoxide-Bridged Artemisinin Dimers to Elucidate the Contribution of Dimerization to Antimalarial Activity.

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Journal:  ACS Infect Dis       Date:  2021-04-01       Impact factor: 5.578
  3 in total

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