Literature DB >> 8176702

Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.

G H Posner1, C H Oh, D Wang, L Gerena, W K Milhous, S R Meshnick, W Asawamahasadka.   

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Year:  1994        PMID： 8176702     DOI： 10.1021/jm00035a003

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  21 in total

1.  In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins.

Authors:  F Benoit-Vical; A Robert; B Meunier
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

2.  Comparison of 3D quantitative structure-activity relationship methods: analysis of the in vitro antimalarial activity of 154 artemisinin analogues by hypothetical active-site lattice and comparative molecular field analysis.

Authors:  J R Woolfrey; M A Avery; A M Doweyko
Journal:  J Comput Aided Mol Des       Date:  1998-03       Impact factor: 3.686

3.  Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models.

Authors:  F Benoit-Vical; A Robert; B Meunier
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

4.  3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents.

Authors:  Charles E Schiaffo; Matthias Rottman; Sergio Wittlin; Patrick H Dussault
Journal:  ACS Med Chem Lett       Date:  2011-04-14       Impact factor: 4.345

5.  Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway.

Authors:  Kaleab A Ribbiso; Laura E Heller; Abigail Taye; Erin Julian; Andreas V Willems; Paul D Roepe
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

6.  Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

Authors:  Susan A Charman; Darren J Creek; Carlo Giannangelo; Lukas Stingelin; Tuo Yang; Leann Tilley
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

7.  Artesunate, an anti-malarial drug, has a potential to inhibit HCV replication.

Authors:  Rongjuan Dai; Xinqiang Xiao; Feng Peng; Mingming Li; Guozhong Gong
Journal:  Virus Genes       Date:  2016-01-06       Impact factor: 2.332

8.  Reaction of antimalarial endoperoxides with specific parasite proteins.

Authors:  W Asawamahasakda; I Ittarat; Y M Pu; H Ziffer; S R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191

9.  The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.

Authors:  Fatima Bousejra-El Garah; Catherine Claparols; Françoise Benoit-Vical; Bernard Meunier; Anne Robert
Journal:  Antimicrob Agents Chemother       Date:  2008-06-16       Impact factor: 5.191

10.  Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.

Authors:  Carmony L Hartwig; Andrew S Rosenthal; John D'Angelo; Carol E Griffin; Gary H Posner; Roland A Cooper
Journal:  Biochem Pharmacol       Date:  2008-10-19       Impact factor: 5.858
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