Literature DB >> 18547199

The risks and benefits of searching for incidental findings in MRI research scans.

Jason M Royal1, Bradley S Peterson.   

Abstract

We weigh the presumed benefits of routinely searching all research scans for incidental findings (IFs) against its substantial risks, including false-positive and false-negative findings, and the possibility of triggering unnecessary, costly evaluations and perhaps harmful treatments. We argue that routinely searching for IFs may not maximize benefits and minimize risks to participants.

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Year:  2008        PMID： 18547199      PMCID： PMC4290840          DOI： 10.1111/j.1748-720X.2008.00274.x

Source DB:  PubMed          Journal:  J Law Med Ethics        ISSN： 1073-1105            Impact factor:   1.718


  15 in total

1.  Asymptomatic Chiari Type I malformations identified on magnetic resonance imaging.

Authors:  J Meadows; M Kraut; M Guarnieri; R I Haroun; B S Carson
Journal:  J Neurosurg       Date:  2000-06       Impact factor: 5.115

Review 2.  Aggregate analysis of the literature for unruptured intracranial aneurysm treatment.

Authors:  Tony Lee; Michael Baytion; Robert Sciacca; J P Mohr; John Pile-Spellman
Journal:  AJNR Am J Neuroradiol       Date:  2005-09       Impact factor: 3.825

3.  Ethical and practical considerations in the management of incidental findings in pediatric MRI studies.

Authors:  Sanjiv Kumra; Manzar Ashtari; Britt Anderson; Kelly L Cervellione; L I Kan
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2006-08       Impact factor: 8.829

4.  MRI of the brain in neurologically healthy middle-aged and elderly individuals.

Authors:  O Salonen; T Autti; R Raininko; A Ylikoski; T Erkinjuntti
Journal:  Neuroradiology       Date:  1997-08       Impact factor: 2.804

5.  Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups.

Authors:  F G Davis; V Kupelian; S Freels; B McCarthy; T Surawicz
Journal:  Neuro Oncol       Date:  2001-07       Impact factor: 12.300

6.  Incidental findings on pediatric MR images of the brain.

Authors:  Brian S Kim; Judy Illes; Richard T Kaplan; Allan Reiss; Scott W Atlas
Journal:  AJNR Am J Neuroradiol       Date:  2002 Nov-Dec       Impact factor: 3.825

7.  Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study.

Authors:  F E de Leeuw; J C de Groot; E Achten; M Oudkerk; L M Ramos; R Heijboer; A Hofman; J Jolles; J van Gijn; M M Breteler
Journal:  J Neurol Neurosurg Psychiatry       Date:  2001-01       Impact factor: 10.154

8.  Prevalence and risk of rupture of intracranial aneurysms: a systematic review.

Authors:  G J Rinkel; M Djibuti; A Algra; J van Gijn
Journal:  Stroke       Date:  1998-01       Impact factor: 7.914

9.  Incidental radiological findings on brain magnetic resonance imaging in first-episode psychosis and chronic schizophrenia.

Authors:  D I Lubman; D Velakoulis; P D McGorry; D J Smith; W Brewer; G Stuart; P Desmond; B Tress; C Pantelis
Journal:  Acta Psychiatr Scand       Date:  2002-11       Impact factor: 6.392

10.  Ethical consideration of incidental findings on adult brain MRI in research.

Authors:  J Illes; A C Rosen; L Huang; R A Goldstein; T A Raffin; G Swan; S W Atlas
Journal:  Neurology       Date:  2004-03-23       Impact factor: 9.910
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  22 in total

1.  Management of incidental findings during imaging research in "healthy" volunteers: current UK practice.

Authors:  T C Booth; A D Waldman; J M Wardlaw; S A Taylor; A Jackson
Journal:  Br J Radiol       Date:  2011-09-21       Impact factor: 3.039

Review 2.  Incidental findings found in "healthy" volunteers during imaging performed for research: current legal and ethical implications.

Authors:  T C Booth; A Jackson; J M Wardlaw; S A Taylor; A D Waldman
Journal:  Br J Radiol       Date:  2010-03-24       Impact factor: 3.039

3.  Psychosocial consequences and severity of disclosed incidental findings from whole-body MRI in a general population study.

Authors:  Carsten Oliver Schmidt; Katrin Hegenscheid; Pia Erdmann; Thomas Kohlmann; Martin Langanke; Henry Völzke; Ralf Puls; Heinrich Assel; Reiner Biffar; Hans Jörgen Grabe
Journal:  Eur Radiol       Date:  2012-12-13       Impact factor: 5.315

4.  A practical approach to incidental findings in neuroimaging research.

Authors:  J M Shoemaker; M T Holdsworth; C Aine; V D Calhoun; R de La Garza; S W Feldstein Ewing; R Hayek; A R Mayer; K A Kiehl; L E Petree; P Sanjuan; A Scott; J Stephen; J P Phillips
Journal:  Neurology       Date:  2011-11-30       Impact factor: 9.910

5.  Stakeholder Opinions And Ethical Perspectives Support Complete Disclosure Of Incidental Findings In MRI Research.

Authors:  John P Phillips; Caitlin Cole; John P Gluck; Jody M Shoemaker; Linda Petree; Deborah Helitzer; Ronald Schrader; Mark Holdsworth
Journal:  Ethics Behav       Date:  2014-10-20

6.  A system for addressing incidental findings in neuroimaging research.

Authors:  Steven C Cramer; Jennifer Wu; Joseph A Hanson; Sarvenaz Nouri; Diraj Karnani; Tony M Chuang; Vu Le
Journal:  Neuroimage       Date:  2011-01-08       Impact factor: 6.556

7.  A Just Standard: The Ethical Management of Incidental Findings in Brain Imaging Research.

Authors:  Mackenzie Graham; Nina Hallowell; Julian Savulescu
Journal:  J Law Med Ethics       Date:  2021       Impact factor: 1.718

8.  A Social Constructivism Decision-Making Approach to Managing Incidental Findings in Neuroimaging Research.

Authors:  Marcie L King
Journal:  Ethics Behav       Date:  2017-04-17

9.  Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management.

Authors:  Katrin Hegenscheid; Rebecca Seipel; Carsten O Schmidt; Henry Völzke; Jens-Peter Kühn; Reiner Biffar; Heyo K Kroemer; Norbert Hosten; Ralf Puls
Journal:  Eur Radiol       Date:  2012-08-22       Impact factor: 5.315

10.  Impact of whole-body MRI in a general population study.

Authors:  Carsten Oliver Schmidt; Elizabeth Sierocinski; Katrin Hegenscheid; Sebastian E Baumeister; Hans J Grabe; Henry Völzke
Journal:  Eur J Epidemiol       Date:  2015-11-23       Impact factor: 8.082
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