Literature DB >> 26877623

Stakeholder Opinions And Ethical Perspectives Support Complete Disclosure Of Incidental Findings In MRI Research.

John P Phillips1, Caitlin Cole2, John P Gluck3, Jody M Shoemaker4, Linda Petree5, Deborah Helitzer6, Ronald Schrader7, Mark Holdsworth8.   

Abstract

How far does a researcher's responsibility extend when an incidental finding is identified? Balancing pertinent ethical principles such as beneficence, respect for persons, and duty to rescue is not always straightforward, particularly in neuroimaging research where empirical data that might help guide decision-making is lacking. We conducted a systematic survey of perceptions and preferences of 396 investigators, research participants and IRB members at our institution. Using the partial entrustment model as described by Richardson, we argue that our data supports universal reading by a neuroradiologist of all research MRI scans for incidental findings and providing full disclosure to all participants.

Entities:  

Keywords:  imaging; incidental findings; paternalism; research ethics

Year:  2014        PMID: 26877623      PMCID: PMC4749272          DOI: 10.1080/10508422.2014.938338

Source DB:  PubMed          Journal:  Ethics Behav        ISSN: 1050-8422


  26 in total

1.  Nontherapeutic research with children: Grimes v Kennedy Krieger Institute.

Authors:  Leonard H Glantz
Journal:  Am J Public Health       Date:  2002-07       Impact factor: 9.308

2.  The ancillary-care responsibilities of medical researchers. An ethical framework for thinking about the clinical care that researchers owe their subjects.

Authors:  Henry S Richardson; Leah Belsky
Journal:  Hastings Cent Rep       Date:  2004 Jan-Feb       Impact factor: 2.683

Review 3.  Practical approaches to incidental findings in brain imaging research.

Authors:  J Illes; M P Kirschen; E Edwards; P Bandettini; M K Cho; P J Ford; G H Glover; J Kulynych; R Macklin; D B Michael; S M Wolf; T Grabowski; B Seto
Journal:  Neurology       Date:  2008-01-29       Impact factor: 9.910

4.  Research malpractice and the issue of incidental findings.

Authors:  Alan C Milstein
Journal:  J Law Med Ethics       Date:  2008       Impact factor: 1.718

5.  The risks and benefits of searching for incidental findings in MRI research scans.

Authors:  Jason M Royal; Bradley S Peterson
Journal:  J Law Med Ethics       Date:  2008       Impact factor: 1.718

6.  A practical approach to incidental findings in neuroimaging research.

Authors:  J M Shoemaker; M T Holdsworth; C Aine; V D Calhoun; R de La Garza; S W Feldstein Ewing; R Hayek; A R Mayer; K A Kiehl; L E Petree; P Sanjuan; A Scott; J Stephen; J P Phillips
Journal:  Neurology       Date:  2011-11-30       Impact factor: 9.910

7.  Mining the mind research network: a novel framework for exploring large scale, heterogeneous translational neuroscience research data sources.

Authors:  Henry J Bockholt; Mark Scully; William Courtney; Srinivas Rachakonda; Adam Scott; Arvind Caprihan; Jill Fries; Ravi Kalyanam; Judith M Segall; Raul de la Garza; Susan Lane; Vince D Calhoun
Journal:  Front Neuroinform       Date:  2010-04-21       Impact factor: 4.081

8.  Brief questions to identify patients with inadequate health literacy.

Authors:  Lisa D Chew; Katharine A Bradley; Edward J Boyko
Journal:  Fam Med       Date:  2004-09       Impact factor: 1.756

Review 9.  Managing incidental findings in human subjects research: analysis and recommendations.

Authors:  Susan M Wolf; Frances P Lawrenz; Charles A Nelson; Jeffrey P Kahn; Mildred K Cho; Ellen Wright Clayton; Joel G Fletcher; Michael K Georgieff; Dale Hammerschmidt; Kathy Hudson; Judy Illes; Vivek Kapur; Moira A Keane; Barbara A Koenig; Bonnie S Leroy; Elizabeth G McFarland; Jordan Paradise; Lisa S Parker; Sharon F Terry; Brian Van Ness; Benjamin S Wilfond
Journal:  J Law Med Ethics       Date:  2008       Impact factor: 1.718

10.  Incidental findings in human subjects research: what do investigators owe research participants?

Authors:  Franklin G Miller; Michelle M Mello; Steven Joffe
Journal:  J Law Med Ethics       Date:  2008       Impact factor: 1.718

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  8 in total

1.  A Just Standard: The Ethical Management of Incidental Findings in Brain Imaging Research.

Authors:  Mackenzie Graham; Nina Hallowell; Julian Savulescu
Journal:  J Law Med Ethics       Date:  2021       Impact factor: 1.718

2.  A Social Constructivism Decision-Making Approach to Managing Incidental Findings in Neuroimaging Research.

Authors:  Marcie L King
Journal:  Ethics Behav       Date:  2017-04-17

3.  Disclosing neuroimaging incidental findings: a qualitative thematic analysis of health literacy challenges.

Authors:  Caitlin E Rancher; Jody M Shoemaker; Linda E Petree; Mark Holdsworth; John P Phillips; Deborah L Helitzer
Journal:  BMC Med Ethics       Date:  2016-10-11       Impact factor: 2.652

Review 4.  Evolution of universal review and disclosure of MRI reports to research participants.

Authors:  Jody M Shoemaker; Caitlin Cole; Linda E Petree; Deborah L Helitzer; Mark T Holdsworth; John P Gluck; John P Phillips
Journal:  Brain Behav       Date:  2016-02-08       Impact factor: 2.708

5.  Ethical framework for the detection, management and communication of incidental findings in imaging studies, building on an interview study of researchers' practices and perspectives.

Authors:  Eline M Bunnik; Lisa van Bodegom; Wim Pinxten; Inez D de Beaufort; Meike W Vernooij
Journal:  BMC Med Ethics       Date:  2017-02-06       Impact factor: 2.652

Review 6.  Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience.

Authors:  Duncan B Clark; Celia B Fisher; Susan Bookheimer; Sandra A Brown; John H Evans; Christian Hopfer; James Hudziak; Ivan Montoya; Margaret Murray; Adolf Pfefferbaum; Deborah Yurgelun-Todd
Journal:  Dev Cogn Neurosci       Date:  2017-06-28       Impact factor: 6.464

Review 7.  Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies: Review and multi-institutional study.

Authors:  Kyoko Takashima; Yoshiyuki Takimoto; Eisuke Nakazawa; Yoshinori Hayashi; Atsushi Tsuchiya; Misao Fujita; Akira Akabayashi
Journal:  Brain Behav       Date:  2017-03-29       Impact factor: 2.708

8.  Health outcomes, utility and costs of returning incidental results from genomic sequencing in a Canadian cancer population: protocol for a mixed-methods randomised controlled trial.

Authors:  Salma Shickh; Marc Clausen; Chloe Mighton; Mariana Gutierrez Salazar; Kathleen-Rose Zakoor; Rita Kodida; Emma Reble; Christine Elser; Andrea Eisen; Seema Panchal; Melyssa Aronson; Tracy Graham; Susan Randall Armel; Chantal F Morel; Ramzi Fattouh; Emily Glogowski; Kasmintan A Schrader; Jada G Hamilton; Kenneth Offit; Mark Robson; June C Carroll; Wanrudee Isaranuwatchai; Raymond H Kim; Jordan Lerner-Ellis; Kevin E Thorpe; Andreas Laupacis; Yvonne Bombard
Journal:  BMJ Open       Date:  2019-10-07       Impact factor: 2.692

  8 in total

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